Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Jonathan H Fox"'
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0250606 (2021)
Huntington's disease (HD) is a neurodegenerative disorder caused by a dominant CAG-repeat expansion in the huntingtin gene. Microglial activation is a key feature of HD pathology, and is present before clinical disease onset. The kynurenine pathway (
Externí odkaz:
https://doaj.org/article/09f6d8fb20fd4f8f8e9c185b729c4aa6
Autor:
Korrapati V. Sathyasaikumar, Verónica Pérez de la Cruz, Benjamín Pineda, Gustavo Ignacio Vázquez Cervantes, Daniela Ramírez Ortega, David W. Donley, Paul L. Severson, Brian L. West, Flaviano Giorgini, Jonathan H. Fox, Robert Schwarcz
Publikováno v:
Antioxidants, Vol 11, Iss 2, p 315 (2022)
Kynurenine 3-monooxygenase (KMO), a key player in the kynurenine pathway (KP) of tryptophan degradation, regulates the synthesis of the neuroactive metabolites 3-hydroxykynurenine (3-HK) and kynurenic acid (KYNA). KMO activity has been implicated in
Externí odkaz:
https://doaj.org/article/cdc89b2e0d4940b7bf5df6c674d7b13d
Autor:
Kiersten L. Berggren, Jianfang Chen, Julia Fox, Jonathan Miller, Lindsay Dodds, Bryan Dugas, Liset Vargas, Amber Lothian, Erin McAllum, Irene Volitakis, Blaine Roberts, Ashley I. Bush, Jonathan H. Fox
Publikováno v:
Redox Biology, Vol 4, Iss C, Pp 363-374 (2015)
Huntington’s disease (HD) is a progressive neurodegenerative disorder caused by a CAG repeat expansion that encodes a polyglutamine tract in huntingtin (htt) protein. Dysregulation of brain iron homeostasis, oxidative stress and neurodegeneration a
Externí odkaz:
https://doaj.org/article/f2b41163a55c427a92abe3a853552d4f
Autor:
Zhen Lu, Eileen Marks, Jianfang Chen, Jenna Moline, Lorraine Barrows, Merl Raisbeck, Irene Volitakis, Robert A. Cherny, Vanita Chopra, Ashley I. Bush, Steven Hersch, Jonathan H. Fox
Publikováno v:
Neurobiology of Disease, Vol 71, Iss , Pp 34-42 (2014)
Disruption of redox homeostasis is a prominent feature in the pathogenesis of Huntington's disease (HD). Selenium an essential element nutrient that modulates redox pathways and has been reported to provide protection against both acute neurotoxicity
Externí odkaz:
https://doaj.org/article/8903c0d1eef14a60bb062a176ca38a83
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162404 (2016)
Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a polyglutamine-repeat expansion in the huntingtin protein. Activation of the kynurenine pathway of tryptophan degradation is implicated in the pathogenesis of HD. Indole
Externí odkaz:
https://doaj.org/article/f3393d3dc7904f608e20d1a6a882998a
Autor:
Marce Vasquez, Madison Vance, Kerry S. Sondgeroth, Jonathan H. Fox, Hally Killion, Hailey Sanderson
Publikováno v:
Journal of Veterinary Diagnostic Investigation. 33:101-103
Chlamydia psittaci has not been reported to cause disease in domestic cats, to our knowledge. In contrast, C. felis infection is common in domestic cats and typically results in conjunctivitis, upper respiratory tract infection, and less frequently p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88baf2339bdad49bfc2cc7fb563028b9
https://doi.org/10.1177/1040638720966960
https://doi.org/10.1177/1040638720966960
Autor:
Jonathan H. Fox, Sonal Agrawal
Publikováno v:
Mitochondrion
Huntington's disease (HD) is a progressive ultimately fatal disorder caused by a glutamine-encoding CAG expansion in the huntingtin (HTT) gene that results in degeneration mainly in striatal and cerebro-cortical brain regions. Mitochondrial dysfuncti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::392388bfaca874cb19d02a3197b264c5
https://doi.org/10.1016/j.mito.2019.03.004
https://doi.org/10.1016/j.mito.2019.03.004
Autor:
Jianfang Chen, Eileen Marks, Barry Lai, Zhaojie Zhang, James A Duce, Linh Q Lam, Irene Volitakis, Ashley I Bush, Steven Hersch, Jonathan H Fox
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77023 (2013)
Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a polyglutamine-encoding CAG expansion in the huntingtin gene. Iron accumulates in the brains of HD patients and mouse disease models. However, the cellular and subcellul
Externí odkaz:
https://doaj.org/article/65ddefe2e67e47bbae30df0469525f4e
Autor:
Jianfang Chen, Eileen Marks, Barry Lai, Zhaojie Zhang, James A. Duce, Linh Q. Lam, Irene Volitakis, Ashley I. Bush, Steven Hersch, Jonathan H. Fox
Publikováno v:
PLoS ONE, Vol 8, Iss 11 (2013)
Externí odkaz:
https://doaj.org/article/215eef667e9d4201bf4101ceac8b33a7
Publikováno v:
Free Radical Biology and Medicine. 120:317-329
Mitochondrial bioenergetic dysfunction is involved in neurodegeneration in Huntington's disease (HD). Iron is critical for normal mitochondrial bioenergetics but can also contribute to pathogenic oxidation. The accumulation of iron in the brain occur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e62a081561a4c87468626c5878966a6
https://doi.org/10.1016/j.freeradbiomed.2018.04.002
https://doi.org/10.1016/j.freeradbiomed.2018.04.002