Design and characterization of mouse IgG1 and IgG2a bispecific antibodies for use in syngeneic models

Autor: Feng Wang, Jordan C. Tsai, Jonathan H. Davis, Bryant Chau, Jia Dong, Sean M. West, Jason M. Hogan, Matthew L. Wheeler, Christine Bee, Winse Morishige, Thomas Cayton, Donata David-brown, Chengyue Zhang, Alexander Kozhich, Tim Sproul, Gavin Dollinger, Arvind Rajpal, Pavel Strop

Publikováno v: mAbs, Vol 12, Iss 1 (2020)

The development of antibody therapeutics relies on animal models that accurately recapitulate disease biology. Syngeneic mouse models are increasingly used with new molecules to capture the biology of complex cancers and disease states, and to provid

Externí odkaz: https://doaj.org/article/f8bc83b729b6455e90c4ca6aa57051c9

Abstract 13880: A Novel, Evidence-based, Standardized Discharge Checklist Reduces Thirty Day Heart Failure Readmissions in an Urban Safety Net Hospital

Autor: Lucas S. Zier, Alexandra B Steverson, Rachel J. Stern, Caren Chen, Paul J Marano, Yifei Ma, Priscilla Y. Hsue, Jonathan H. Davis

Publikováno v: Circulation. 142

Introduction: Safety net hospitals are more likely to be penalized for heart failure (HF) readmissions. There is limited evidence as to whether readmission reduction strategies are effective in this setting. We hypothesized that a discharge checklist

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::19eff617b1287a1871504946d169654c
https://doi.org/10.1161/circ.142.suppl_3.13880

GSK3732394: a Multi-specific Inhibitor of HIV Entry

Autor: Thomas McDonagh, David L. Wensel, Sebastien Tabruyn, Zhufang Li, Tracy S. Mitchell, Jonathan H. Davis, Yongnian Sun, Sharon Zhang, Mark Krystal, Mark I. Cockett, Patrick Nef, David R. Langley

Long-acting antiretrovirals could provide a useful alternative to daily oral therapy for HIV-1-infected individuals. Building on a bi-specific molecule with adnectins targeting CD4 and gp41, a potential long-acting biologic, GSK3732394, was developed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c17986092965a8eab3c5db82a28136fd
https://europepmc.org/articles/PMC6798092/

Beyond ΛCDM: Problems, solutions, and the road ahead

Autor: Jonas Enander, Jose Beltrán Jiménez, Philip Bull, Seshadri Nadathur, Bin Hu, Eloisa Bentivegna, Emilio Bellini, Edvard Mörtsell, Ignacy Sawicki, Signe Riemer-Sørensen, Sebastien Clesse, Ippocratis D. Saltas, Massimiliano Rinaldi, Adam R. Solomon, Julian Adamek, L. Verde, Daniele A. Steer, Francisco Villaescusa-Navarro, Ismael Tereno, Enea Di Dio, Hans A. Winther, Marcel S. Pawlowski, Thiago S. Pereira, Glenn D. Starkman, Tessa Baker, Johannes Noller, Lavinia Heisenberg, Miguel Quartin, Douglas Spolyar, Roman Pasechnik, Yashar Akrami, Jonathan H. Davis, Vincenzo Salzano, Mikael von Strauss, Alan Heavens, Jeremy Sakstein, Stefano Camera, A. Ricciardone, Claudio Llinares, Roy Maartens

Publikováno v: Bull, P, Akrami, Y, Adamek, J, Baker, T, Bellini, E, Jiménez, J B, Bentivegna, E, Camera, S, Clesse, S, Davis, J H, Dio, E D, Enander, J, Heavens, A, Heisenberg, L, Hu, B, Llinares, C, Maartens, R, Mörtsell, E, Nadathur, S, Noller, J, Pasechnik, R, Pawlowski, M S, Pereira, T S, Quartin, M, Ricciardone, A, Riemer-Sørensen, S, Rinaldi, M, Sakstein, J, Saltas, I D, Salzano, V, Sawicki, I, Solomon, A R, Spolyar, D, Starkman, G D, Steer, D, Tereno, I, Verde, L, Villaescusa-Navarro, F, Strauss, M V & Winther, H A 2016, ' Beyond ΛCDM : problems, solutions, and the road ahead ', Physics of the Dark Universe, vol. 12, pp. 56-99 . https://doi.org/10.1016/j.dark.2016.02.001
Physics of the Dark Universe
Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona
Bull, P, Akrami, Y, Adamek, J, Baker, T, Bellini, E, Beltrán Jiménez, J, Bentivegna, E, Camera, S, Clesse, S, Davis, J H, Di Dio, E, Enander, J, Heavens, A, Heisenberg, L, Hu, B, Llinares, C, Maartens, R, Mörtsell, E, Nadathur, S, Noller, J, Pasechnik, R, Pawlowski, M S, Pereira, T S, Quartin, M, Ricciardone, A, Riemer-Sørensen, S, Rinaldi, M, Sakstein, J, Saltas, I D, Salzano, V, Sawicki, I, Solomon, A R, Spolyar, D, Starkman, G D, Steer, D, Tereno, I, Verde, L, Villaescusa-Navarro, F, von Strauss, M & Winther, H A 2016, ' Beyond ΛCDM : Problems, solutions, and the road ahead ', Physics of the Dark Universe, vol. 12, pp. 56-99 . https://doi.org/10.1016/j.dark.2016.02.001

Despite its continued observational successes, there is a persistent (and growing) interest in extending cosmology beyond the standard model, ΛCDM. This is motivated by a range of apparently serious theoretical issues, involving such questions as th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2203d82141a444f9d3d622d224f940e
https://doi.org/10.1016/j.dark.2016.02.001

IL-2/CD25: A long-acting fusion protein that promotes immune tolerance by selectively targeting the IL-2R on regulatory T cells

Autor: Jonathan H. Davis, Alejandro Moro, Aaron P. Yamniuk, Martine Loubeau, Yuguang Ban, Thomas R. Malek, Aixin Yu, Jaren M. Arbanas, Anil Thankappan, Sunnie Hsiung, Xi Chen, James Keegan, Mary Struthers, Natasha C. Ward

Low-dose IL-2 represents an immunotherapy to selectively expand regulatory T cells (Tregs) to promote tolerance in patients with autoimmunity. In this article, we show that a fusion protein (FP) of mouse IL-2 and mouse IL-2Rα (CD25), joined by a non

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb78e3d1a456ad2bd65ff1f98b1779bb
https://europepmc.org/articles/PMC6200646/