Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Jonathan H, Schatz"'
Publikováno v:
Blood Cancer Journal, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Despite recent advances in frontline therapy for diffuse large B-cell lymphoma (DLBCL), at least a third of those diagnosed still will require second or further lines for relapsed or refractory (rel/ref) disease. A small minority of these ca
Externí odkaz:
https://doaj.org/article/f226ac0f9e7745c9abe05ab2619449d2
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101919- (2022)
Summary: Here, we present a protocol using MATRIX (mass spectrometry analysis of active translation factors using ribosome density fractionation and isotopic labeling experiments) platform to investigate changes of the protein synthesis machinery in
Externí odkaz:
https://doaj.org/article/972dceb72d1442c1adaf3ad258bb3094
Autor:
Nathan C. Balukoff, J. J. David Ho, Phaedra R. Theodoridis, Miling Wang, Michael Bokros, Lis M. Llanio, Jonathan R. Krieger, Jonathan H. Schatz, Stephen Lee
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Translatome remodelling controls stress-adaptive protein output. Here the authors reveal that in response to stimuli, eIF5A functions as a pH-regulated translation factor that responds to fermentation-induced acidosis affecting cellular metabolism.
Externí odkaz:
https://doaj.org/article/93b48d789e3e4b9d8f527f9c594d44a2
Autor:
J. J. David Ho, Nathan C. Balukoff, Phaedra R. Theodoridis, Miling Wang, Jonathan R. Krieger, Jonathan H. Schatz, Stephen Lee
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
mRNA translation efficiency is regulated in response to stimuli. Here the authors employ mass spectrometry analysis of ribosome fractions and show that under hypoxia, oxygen-sensitive RNA binding proteins enhance the translation efficiency of glycoly
Externí odkaz:
https://doaj.org/article/754a4b16d6cf4bd486c30441585007ea
Autor:
Ajay Major, Jovian Yu, Navika D. Shukla, Rachel Treitman, Manali K. Kamdar, Bradley M. Haverkos, James Godfrey, Melissa A. Babcook, Timothy J. Voorhees, Sophie G Carlson, Daria Gaut, Caspian Oliai, Jason T. Romancik, Allison Winter, Brian T. Hill, Radhika Bansal, Jose C. Villasboas, Imran A. Nizamuddin, Reem Karmali, Lindsey A. Fitzgerald, Deborah M. Stephens, Priyanka A. Pophali, Asaad Trabolsi, Jonathan H. Schatz, Marie Hu, Veronika Bachanova, Michael J Slade, Nathan Singh, Nausheen Ahmed, Joseph P. McGuirk, Michael R. Bishop, Peter A. Riedell, Justin Kline
Publikováno v:
Blood. 140:1328-1331
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9dd21cab171f68ea4052fe7440b870b3
https://doi.org/10.1182/blood-2022-157829
https://doi.org/10.1182/blood-2022-157829
Autor:
Michael D. Jain, Bachisio Ziccheddu, Caroline A. Coughlin, Rawan Faramand, Anthony J. Griswold, Kayla M. Reid, Meghan Menges, Yonghong Zhang, Ling Cen, Xuefeng Wang, Mohammad Hussaini, Ola Landgren, Marco L. Davila, Jonathan H. Schatz, Frederick L. Locke, Francesco Maura
Publikováno v:
Blood. 140:491-503
CD19-directed chimeric antigen receptor (CAR-19) T cells are groundbreaking immunotherapies approved for use against large B-cell lymphomas. Although host inflammatory and tumor microenvironmental markers associate with efficacy and resistance, the t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa285563b44c42df890af2e335e6e767
https://doi.org/10.1182/blood.2021015008
https://doi.org/10.1182/blood.2021015008
Publikováno v:
Case Reports in Hematology, Vol 2019 (2019)
Involvement of the central nervous system by chronic lymphocytic leukemia/small lymphocytic lymphoma is exceedingly rare, and currently no risk factors have been described. We report the case of a patient with concomitant chronic lymphocytic leukemia
Externí odkaz:
https://doaj.org/article/450048b384344b2d91f3aa6c7fc36b5d
Autor:
Ajay Major, Jovian Yu, Navika Shukla, Yan Che, Theodore G Karrison, Rachel Treitman, Manali Kamdar, Bradley M Haverkos, James Godfrey, Melissa A Babcook, Timothy J Voorhees, Sophie Gabrielle Carlson, Daria Gaut, Caspian Oliai, Jason T. Romancik, Allison M Winter, Brian T. Hill, Radhika Bansal, Jose Caetano Villasboas, Imran A. Nizamuddin, Reem Karmali, Lindsey A. Fitzgerald, Deborah M. Stephens, Priyanka A Pophali, Asaad Trabolsi, Jonathan H Schatz, Marie Hu, Veronika Bachanova, Michael Slade, Nathan Singh, Nausheen Ahmed, Joseph P McGuirk, Michael R. Bishop, Peter A. Riedell, Justin Kline
Publikováno v:
Blood Advances.
Checkpoint inhibitor (CPI) therapy with anti-PD-1 antibodies has been associated with mixed outcomes in small cohorts of aggressive B-cell lymphoma patients following CAR T-cell therapy failure. To more definitively define CPI therapy efficacy in thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::857d0457d554011421daf5721f4a4201
https://doi.org/10.1182/bloodadvances.2023010016
https://doi.org/10.1182/bloodadvances.2023010016
Autor:
Jonathan H. Schatz, Roger M. Leblanc, Daniel Bilbao, Francisco Vega, Melissa W. Taggart, Austin D. Newsam, Yuguang Ban, Zhen Gao, Braulio C.L.B. Ferreira, Lingxiao Li, Evan R. Roberts, Asaad Trabolsi, Piumi Y. Liyanage, Artavazd Arumov
New treatments are needed to address persistent unmet clinical needs for diffuse large B-cell lymphoma (DLBCL). Overexpression of transferrin receptor 1 (TFR1) is common across cancer and permits cell-surface targeting of specific therapies in precli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c9f11be22eb2c2298d3d27fb53a229d
https://doi.org/10.1158/0008-5472.c.6512452.v1
https://doi.org/10.1158/0008-5472.c.6512452.v1
Autor:
Jonathan H. Schatz, Eli Chapman, Abimael D. Rodríguez, Graham Packham, Cyril H. Benes, Francisco Vega, Patricia Greninger, Gillian Paine-Murrieta, Andrew J. Ambrose, Christopher J. Zerio, Praechompoo Pongtornpipat, Amit D. Amin, Lingxiao Li, Luis A. Amador, Carlos Jiménez-Romero, Elizabeth Lemm, Sarah Wilmore, Alison M. Yeomans, Joseph Tillotson, Tara L. Peters
Figure S1. Elatol was submitted to a 96-member kinome screen to evaluate specificity. Figure S2. A) Michaelis-Menten curves of eIF4A1 wild type (blue), K82R (red), and K238E (green). Michaelis- Menten constants for eIF4A1 wild type and mutants in tab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b0c08aa1ad75e37b8b895a22244a71
https://doi.org/10.1158/1078-0432.22469778.v1
https://doi.org/10.1158/1078-0432.22469778.v1