Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Jonathan Grote"'
Autor:
Jonathan Grote, Susan Gayda
Publikováno v:
Tetrahedron Letters. 55:5955-5959
A new method for synthesizing regiospecific 3-position vitamin D conjugates is described. Reaction of either 25-dihydroxyvitamin D2 or 25-dihydroxyvitamin D3 with p -nitrophenylchloroformate resulted in conversion to the respective 3- p -nitrophenylc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cb7433f06beed9a2e18d675774015af
https://doi.org/10.1016/j.tetlet.2014.08.006
https://doi.org/10.1016/j.tetlet.2014.08.006
Publikováno v:
Tetrahedron Letters. 53:6751-6754
An efficient synthesis of a single conjugate of gentamicin is described. Reaction of the primarily three component gentamicin complex with excess benzyl chloroformate provided a mixture of the amine-protected components which were separable at scale
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81663b8525c229446bc72473d7598a01
https://doi.org/10.1016/j.tetlet.2012.09.113
https://doi.org/10.1016/j.tetlet.2012.09.113
Publikováno v:
Tetrahedron Letters. 53:5331-5334
An efficient one-step synthesis of a methotrexate fluorescein conjugate is described. Reaction of dried methotrexate with 5-aminofluorescein, mediated by HBTU, produced an isomerically pure methotrexate conjugate in good yield. Proof of structure was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ac2a2b8162587100303703e36538ba8
https://doi.org/10.1016/j.tetlet.2012.07.104
https://doi.org/10.1016/j.tetlet.2012.07.104
Autor:
Jonathan Grote, Yon-Yih Chen
Publikováno v:
Tetrahedron Letters. 55:676-678
An efficient synthesis of a chemiluminescent valproic acid conjugate is described. Reaction of diethyl propylmalonate with 4-bromobutylphthalimide produced an amino protected malonate, which was deprotected with hydrazine and treated with HCl to prod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b48f40f69a7a922c1e1af28f1db690bf
https://doi.org/10.1016/j.tetlet.2013.11.109
https://doi.org/10.1016/j.tetlet.2013.11.109
Autor:
Yon-Yih Chen, Rad K. Nair, Sushil D. Rege, Larissa Coombs Harwick, Gangamani S. Beligere, Jonathan Grote, Kevin R. Rupprecht, Jeffrey R. Fishpaugh, Zhen Lin
Publikováno v:
Analytical Biochemistry. 407:160-164
Dot-blot is a versatile and simple analysis to perform. We adapted this method as a simple identity test for monoclonal antibodies to a number of small compounds: three transplant drugs, an anticonvulsant, a steroid, an anticancer drug, and an antibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5531d4e68f1b40d0c952ca01f957086
https://doi.org/10.1016/j.ab.2010.08.003
https://doi.org/10.1016/j.ab.2010.08.003
Autor:
Maciej Adamczyk, Jonathan Grote
Publikováno v:
Organic Preparations and Procedures International. 33:95-100
(2001). A PRACTICAL METHOD FOR THE SYNTHESIS OF PHENOPHTHALEIN SPIROLACTAMS. Organic Preparations and Procedures International: Vol. 33, No. 1, pp. 95-100.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41707a200d1c4efdf26875512203a9d6
https://doi.org/10.1080/00304940109356580
https://doi.org/10.1080/00304940109356580
Autor:
Maciej Adamczyk, Jonathan Grote
Publikováno v:
Synthetic Communications. 31:2681-2690
Reaction of fluorescein methyl ester at ambient temperature with a variety of amines containing different functional groups afforded a family of spirolactams, the structures of which were verified by MS, NMR, and x-ray crystallography. Bis-spirolacta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::657c4bab39b63b0927e507487323d3c7
https://doi.org/10.1081/scc-100105396
https://doi.org/10.1081/scc-100105396
Publikováno v:
Steroids. 64:283-290
The 5 and 6-isomers of O-(fluoresceinylmethyl)hydroxylamine reacted with a representative sample of oxo-steroids (6-oxoestradiol, estrone, norethindrone, cortisol, progesterone, and digitoxin-dialdehyde) to produce O-(fluoresceinylmethyl)oxime conjug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::104d1f35a6ebaa058368498cfa9170a0
https://doi.org/10.1016/s0039-128x(99)00004-5
https://doi.org/10.1016/s0039-128x(99)00004-5
Autor:
Jonathan Grote, Maciej Adamczyk
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:245-248
A study of the reactivity of esters with oxygenated linkers in lipase catalyzed transformations demonstrates that enhanced reactivity is observed in amidation reactions, but diminished reactivity is observed in hydrolyses using the same lipase. Two r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d921d4044bc8969f4c25495c8956d62
https://doi.org/10.1016/s0960-894x(98)00733-1
https://doi.org/10.1016/s0960-894x(98)00733-1
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:885-890
Recently, an interest in the development of new vancomycin derivatives has been demonstrated. Here, the feasibility of using lipases, particularly those from Pseudomonas sp., for the hydrolysis of vancomycin alkyl esters is demonstrated. Benzyl ester
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eace28e02eefb8c117795d274536d559
https://doi.org/10.1016/s0960-894x(98)00109-7
https://doi.org/10.1016/s0960-894x(98)00109-7