Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Jonathan Greenbaum"'
Autor:
Panpan Long, Le Wang, Hangjing Tan, Ruping Quan, Zihao Hu, Minghua Zeng, Ziheng Deng, Hualin Huang, Jonathan Greenbaum, Hongwen Deng, Hongmei Xiao
Publikováno v:
Journal of Ovarian Research, Vol 17, Iss 1, Pp 1-10 (2024)
Abstract Background The etiology of premature ovarian insufficiency, that is, the loss of ovarian activity before 40 years of age, is complex. Studies suggest that genetic factors are involved in 20–25% of cases. The aim of this study was to explor
Externí odkaz:
https://doaj.org/article/3a4bbb22af424cc486f0ba158146c9ea
Autor:
Shengran Wang, Jonathan Greenbaum, Chuan Qiu, Russell H. Swerdlow, Mohammad Haeri, Yun Gong, Hui Shen, Hongmei Xiao, Hongwen Deng
Publikováno v:
Genes and Diseases, Vol 11, Iss 6, Pp 101337- (2024)
Recent studies have explored the spatial transcriptomics patterns of Alzheimer's disease (AD) brain by spatial sequencing in mouse models, enabling the identification of unique genome-wide transcriptomic features associated with different spatial reg
Externí odkaz:
https://doaj.org/article/45eb13b5068241dfbed3c9676048d340
Autor:
Xu Lin, Hong-Mei Xiao, Hui-Min Liu, Wan-Qiang Lv, Jonathan Greenbaum, Rui Gong, Qiang Zhang, Yuan-Cheng Chen, Cheng Peng, Xue-Juan Xu, Dao-Yan Pan, Zhi Chen, Zhang-Fang Li, Rou Zhou, Xia-Fang Wang, Jun-Min Lu, Zeng-Xin Ao, Yu-Qian Song, Yin-Hua Zhang, Kuan-Jui Su, Xiang-He Meng, Chang-Li Ge, Feng-Ye Lv, Zhe Luo, Xing-Ming Shi, Qi Zhao, Bo-Yi Guo, Neng-Jun Yi, Hui Shen, Christopher J. Papasian, Jie Shen, Hong-Wen Deng
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Although the gut microbiota has been reported to influence osteoporosis risk, the individual species involved, and underlying mechanisms, remain largely unknown. We performed integrative analyses in a Chinese cohort of peri-/post-menopausal
Externí odkaz:
https://doaj.org/article/b8089b80377041d18871e82953a90031
Autor:
Shengran Wang, Yun Gong, Zun Wang, Xianghe Meng, Zhe Luo, Christopher J. Papasian, Jonathan Greenbaum, Yisu Li, Qilan Liang, Yiping Chen, Xiaohua Li, Qiu Xiang, Hiuxi Zhang, Ying Liu, Liang Cheng, Yihe Hu, Lijun Tan, Hui Shen, Hongmei Xiao, Hongwen Deng
Publikováno v:
Human Genomics, Vol 17, Iss 1, Pp 1-21 (2023)
Abstract Background While transcription factor (TF) regulation is known to play an important role in osteoblast development, differentiation, and bone metabolism, the molecular features of TFs in human osteoblasts at the single-cell resolution level
Externí odkaz:
https://doaj.org/article/5955835b3f3244e394970de0c43a8c5d
Autor:
Xiao-Hua Li, Wei-Wei Pang, Yue Zhang, Dan-Yang Liu, Qiao-Rong Yi, Ning Wang, Fu-Rong Zhang, Yun Deng, Xiang-Ding Chen, Jonathan Greenbaum, Hong-Mei Xiao, Hong-Wen Deng, Li-Jun Tan
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: Lipid pathways have been implicated in the pathogenesis of osteoporosis (OP). Lipid-lowering drugs may be used to prevent and treat OP. However, the causal interpretation of results from traditional observational designs is controversial
Externí odkaz:
https://doaj.org/article/4e5054e920bf42d7b28f96aa42204676
Autor:
Kuan-Jui Su, Xing-Ying Chen, Rui Gong, Qi Zhao, Shi-Di Hu, Mei-Chen Feng, Ye Li, Xu Lin, Yin-Hua Zhang, Jonathan Greenbaum, Qing Tian, Hui Shen, Hong-Mei Xiao, Jie Shen, Hong-Wen Deng
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Obesity is associated with various adverse health outcomes. Body fat (BF) distribution is recognized as an important factor of negative health consequences of obesity. Although metabolomics studies, mainly focused on body mass index (BMI) and waist c
Externí odkaz:
https://doaj.org/article/651bd6ff1e0b40fcac1912b816fe5166
Autor:
Shengran Wang, Jonathan Greenbaum, Chuan Qiu, Yun Gong, Zun Wang, Xu Lin, Yong Liu, Pei He, Xianghe Meng, Qiang Zhang, Hui Shen, Krishna Chandra Vemulapalli, Fernando L. Sanchez, Martin R. Schiller, Hongmei Xiao, Hongwen Deng
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
BackgroundWhile osteoimmunology interactions between the immune and skeletal systems are known to play an important role in osteoblast development, differentiation and bone metabolism related disease like osteoporosis, such interactions in either bon
Externí odkaz:
https://doaj.org/article/2a34c4afd11e40aeaa2acb24fe219e2e
Autor:
Meng Song, Jonathan Greenbaum, Joseph Luttrell, Weihua Zhou, Chong Wu, Zhe Luo, Chuan Qiu, Lan Juan Zhao, Kuan-Jui Su, Qing Tian, Hui Shen, Huixiao Hong, Ping Gong, Xinghua Shi, Hong-Wen Deng, Chaoyang Zhang
Publikováno v:
Frontiers in Artificial Intelligence, Vol 5 (2022)
Genotype imputation has a wide range of applications in genome-wide association study (GWAS), including increasing the statistical power of association tests, discovering trait-associated loci in meta-analyses, and prioritizing causal variants with f
Externí odkaz:
https://doaj.org/article/1002be0b29d54fc69e4b78b22546b6d0
Autor:
Shuang Liang, Danyang Liu, Zhengwu Xiao, Jonathan Greenbaum, Hui Shen, Hongmei Xiao, Hongwen Deng
Publikováno v:
Pharmaceuticals, Vol 16, Iss 4, p 607 (2023)
Sarcopenia, characterized by age-related loss of muscle mass, strength, and decreased physical performance, is a growing public health challenge amid the rapidly ageing population. As there are no approved drugs that target sarcopenia, it has become
Externí odkaz:
https://doaj.org/article/2120e95170ab40d2a160f5be4bcd3e3e
Autor:
Jonathan Greenbaum, Xu Lin, Kuan-Jui Su, Rui Gong, Hui Shen, Jie Shen, Hong-Mei Xiao, Hong-Wen Deng
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
While the gut microbiome has been reported to play a role in bone metabolism, the individual species and underlying functional mechanisms have not yet been characterized. We conducted a systematic multi-omics analysis using paired metagenomic and unt
Externí odkaz:
https://doaj.org/article/c9c7f0b603964ef38f299d9da4a7095f