Investigating the structure–activity relationship of 1,2,4-triazine G-protein-coupled receptor 84 (GPR84) antagonists

Autor: Amit Mahindra, Laura Jenkins, Sara Marsango, Mark Huggett, Margaret Huggett, Lindsay Robinson, Jonathan Gillespie, Muralikrishnan Rajamanickam, Angus Morrison, Stuart McElroy, Irina G. Tikhonova, Graeme Milligan, Andrew G. Jamieson

Publikováno v: Mahindra, A, Jenkins, L, Marsango, S, Huggett, M, Huggett, M, Robinson, L, Gillespie, J, Rajamanickam, M, Morrison, A, McElroy, S, Tikhonova, I G, Milligan, G & Jamieson, A G 2022, ' Investigating the Structure-Activity Relationship of 1,2,4-Triazine G-Protein-Coupled Receptor 84 (GPR84) Antagonists ', Journal of Medicinal Chemistry, vol. 65, no. 16, pp. 11270–11290 . https://doi.org/10.1021/acs.jmedchem.2c00804

G-protein-coupled receptor 84 (GPR84) is a proinflammatory orphan G-protein-coupled receptor implicated in several inflammatory and fibrotic diseases. Several agonist and antagonist ligands have been developed that target GPR84; however, a noncompeti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f04505f33b851dac9c2727e94441dc5
https://eprints.gla.ac.uk/275398/1/275398.pdf

Consistency of urban background black carbon concentration measurements by portable AE51 and reference AE22 aethalometers : effect of corrections for filter loading

Autor: Chun Lin, Fiona Sutherland, Mathew R. Heal, Eliani Ezani, Scott Hamilton, Iain J. Beverland, Nicola Masey, Jonathan Gillespie

Publikováno v: Glasgow, R E, Ezani, E, Gillespie, J, Sutherland, F, Lin, C, Glasgow, R E, Heal, M R & Beverland, I J 2020, ' Consistency of Urban Background Black Carbon Concentration Measurements by Portable AE51 and Reference AE22 Aethalometers: Effect of Corrections for Filter Loading ', Aerosol and Air Quality Research, vol. 20, no. 2, pp. 329-340 . https://doi.org/10.4209/aaqr.2019.03.0145

Measurement of exposure to black carbon with portable monitoring devices is an important part of research on the health impacts of combustion-related air pollutants. We collected 786 hourly-averaged equivalent black carbon (eBC) measurements from co-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cc8f4311496c02cc0a36b12382ab7b9
https://strathprints.strath.ac.uk/69340/7/Masey_etal_AAQR_2019_Consistency_of_urban_background_black_carbon_concentration_measurements.pdf

Identification of A Novel Class of Benzofuran Oxoacetic Acid-Derived Ligands that Selectively Activate Cellular EPAC1

Autor: John Robinson, Stuart P. McElroy, Philip S. Jones, Graeme Barker, Euan Parnell, Helma Rutjes, Lindsay Robinson, Angus Morrison, Elizabeth M. Beck, Andrew D. Pannifer, Martin Timmerman, Angela Cowley, Jolanta Wiejak, Veronique Hamon, Holger Rehmann, Urszula Luchowska-Stańska, Jonathan Gillespie, David Morgan, Stephen J. Yarwood, Alison Porter, Pravin Mahajan

Publikováno v: Cells
Volume 8
Issue 11

Cyclic AMP promotes EPAC1 and EPAC2 activation through direct binding to a specific cyclic nucleotide-binding domain (CNBD) within each protein, leading to activation of Rap GTPases, which control multiple cell responses, including cell proliferation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::677a116fcb1675edbcc36ca4fb30482f
https://pubmed.ncbi.nlm.nih.gov/31726720

Influence of wind-speed on short duration NO2 measurements using Palmes and Ogawa passive diffusion samplers

Autor: Mathew R. Heal, Scott Hamilton, Jonathan Gillespie, Nicola Masey, Iain J. Beverland

Publikováno v: Masey, N, Gillespie, J, Heal, M R, Hamilton, S & Beverland, I J 2017, ' Influence of wind-speed on short-duration NO2 measurements using Palmes and Ogawa passive diffusion samplers ', Atmospheric Environment, vol. 160, pp. 70-76 . https://doi.org/10.1016/j.atmosenv.2017.04.008

We assessed the precision and accuracy of nitrogen dioxide (NO2) concentrations over 2-day, 3-day and 7-day exposure periods measured with the following types of passive diffusion samplers: standard (open) Palmes tubes; standard Ogawa samplers with c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5bc5ff3f0df631c4c342e05c0028b15
https://strathprints.strath.ac.uk/60440/8/Masey_etal_AE_2017_Influence_of_wind_speed_on_short_duration_NO2_measurements.pdf

Development, evaluation, and comparison of land use regression modeling methods to estimate residential exposure to nitrogen dioxide in a cohort study

Autor: Iain J. Beverland, Scott Hamilton, Sandosh Padmanabhan, Jonathan Gillespie

We used a network of 135 NO2 passive diffusion tube sites to develop land use regression (LUR) models in a UK conurbation. Network sites were divided into 4 groups (32 – 35 sites per group) and models developed using combinations of 1 - 3 groups of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36ba8d386d3f92c198d197083f3330c4
https://eprints.gla.ac.uk/132169/1/132169.pdf