Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Jonathan G. Drachman"'
Autor:
Mohamad Hussein, James R. Berenson, Ruben Niesvizky, Nikhil Munshi, Jeffrey Matous, Ronald Sobecks, Kate Harrop, Jonathan G. Drachman, Nancy Whiting
Publikováno v:
Haematologica, Vol 95, Iss 5 (2010)
This first-in-human, phase I study evaluated the safety, maximum-tolerated dose, pharmacokinetics, and antitumor activity of dacetuzumab in 44 patients with advanced multiple myeloma. Patients received intravenous dacetuzumab, either in 4 uniform wee
Externí odkaz:
https://doaj.org/article/694f011bd49545cca3dc00ab1fb26c49
Autor:
Ranjana H. Advani, Andres Forero-Torres, Stephen M. Ansell, Luis Fayad, Bertrand Coiffier, Robert K. Stuart, David Belada, Kazimierz Kuliczkowski, Edmund Ng, Jonathan G. Drachman, Nancy L. Bartlett
Publikováno v:
Leukemia & Lymphoma. 56:2569-2578
Single-agent dacetuzumab has demonstrated antitumor activity in relapsed/refractory diffuse large B-cell lymphoma (DLBCL). Preclinical data demonstrated improved dacetuzumab antitumor activity in combination with rituximab, ± chemotherapy. We design
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::573868e03282795b5aebe8b4eea330a1
https://doi.org/10.3109/10428194.2015.1007504
https://doi.org/10.3109/10428194.2015.1007504
Autor:
Peter D. Senter, Jonathan G. Drachman
Publikováno v:
Hematology. 2013:306-310
For more than a century, the concept of a “magic bullet” to deliver cytotoxic therapy to the site of disease has been envisioned but only recently have technological advances enabled antibody-drug conjugates to fulfill that dream. The recent appr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94524cccd53742d71f6fa02a36ee4d37
https://doi.org/10.1182/asheducation-2013.1.306
https://doi.org/10.1182/asheducation-2013.1.306
Autor:
Andres Forero-Torres, Han Myint, Sunita D. Nasta, Nancy L. Bartlett, Nancy Whiting, Albert F. LoBuglio, Anne W. Beaven, Jonathan G. Drachman, Donald W. Northfelt, Craig H. Moskowitz
Publikováno v:
Leukemia & Lymphoma. 54:277-283
Dacetuzumab, a CD40-targeted, humanized antibody, mediates antitumor activity through effector cell functions and direct apoptotic signal transduction. Preclinical studies demonstrated synergistic activity between dacetuzumab, gemcitabine and rituxim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e718ed5b2abe901235015075854754de
https://doi.org/10.3109/10428194.2012.710328
https://doi.org/10.3109/10428194.2012.710328
Autor:
Jonathan G. Drachman, Richard R. Furman, Andres Forero-Torres, Joseph D. Rosenblatt, Kate Harrop, Nancy Whiting, Ranjana H. Advani, Hong Ren, Anas Younes
Publikováno v:
Journal of Clinical Oncology. 27:4371-4377
Purpose To evaluate the safety, maximum-tolerated dose (MTD), pharmacokinetics, and antitumor activity of dacetuzumab in patients with refractory or recurrent B-cell non-Hodgkin's lymphoma (NHL). Patients and Methods In this open-label, dose-escalati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a671702d23e3d130afbaae007dd04835
https://doi.org/10.1200/jco.2008.21.3017
https://doi.org/10.1200/jco.2008.21.3017
Autor:
Ebrahim Shafizadeh, H. Jan Johnson, Eric L. Pierce, Manish J. Gandhi, Diana M. Gilligan, Nathaniel B. Langer, Jonathan G. Drachman, Barry H. Paw
Publikováno v:
Experimental Hematology. 37:901-908
Objective A missense mutation in the microtubule-associated serine/threonine-like kinase gene ( MASTL, FLJ14813) on human chromosome 10 was previously linked to a novel form of autosomal dominant inherited thrombocytopenia in a single pedigree. The m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dab96aa73a08e1552ac1336f8de3f280
https://doi.org/10.1016/j.exphem.2009.05.005
https://doi.org/10.1016/j.exphem.2009.05.005
Autor:
Lowell L. Hart, Ari D. Baron, Arthur H. Rosenberg, David E. McCune, Dennis M. Miller, Laurie E. Grove, Paul Swanson, Mark U. Rarick, Charles M. Rudin, Jonathan G. Drachman, Andrew D. Jacobs, Michael D. Thorn, Robert A. Figlin, Helen J. Ross
Publikováno v:
Lung Cancer. 54:69-77
Summary Purpose Chemotherapy prolongs survival and improves quality of life (QOL) for good performance status (PS) patients with advanced non-small cell lung cancer (NSCLC). Targeted therapies may improve chemotherapy effectiveness without worsening
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c93978185ef4e9a2ff9f9774551ad2b6
https://doi.org/10.1016/j.lungcan.2006.05.020
https://doi.org/10.1016/j.lungcan.2006.05.020
Publikováno v:
Blood Cells, Molecules, and Diseases. 35:70-73
Transfusion of allogeneic platelets is the mainstay of therapy for patients with thrombocytopenic hemorrhage. However, donated platelets can only be stored for 5 days and are maintained at room temperature, increasing the risk of bacterial growth. De
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59efa7266b5bac90d7e0772059c7a333
https://doi.org/10.1016/j.bcmd.2005.04.002
https://doi.org/10.1016/j.bcmd.2005.04.002
Autor:
Felisa C. Molinas, Ana C. Glembotsky, Manish J. Gandhi, Paula G. Heller, Carlos José Pirola, Carrie L. Cummings, Jonathan G. Drachman, Rosana F. Marta, Laura I. Kornblihtt
Publikováno v:
Blood. 105:4664-4670
Germ-line heterozygous mutations in the hematopoietic transcription factor AML1 (RUNX1) have been identified in patients with familial platelet disorder with predisposition to acute myelogenous leukemia (FPD/AML), which is characterized by thrombocyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56c8be9d5a8ae7b0bd2e231759e1d022
https://doi.org/10.1182/blood-2005-01-0050
https://doi.org/10.1182/blood-2005-01-0050
Autor:
T.W. Pendergrass, Diana M. Gilligan, Jonathan G. Drachman, D.M. Kyles, D.M. Rumsey, D.C. Matthews, Theresa Nester, C.C. Howell, R.V. Maier
Publikováno v:
Transfusion. 44:1720-1723
BACKGROUND: Although young women who are D– occasionally receive unintentional transfusions with D+ red blood cells (RBCs), there are little data to assist with management of such an event. Two cases of D– girls transfused with D+ RBCs are report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a145a09a56bc533f801c8b8e00f0f58
https://doi.org/10.1111/j.0041-1132.2004.04161.x
https://doi.org/10.1111/j.0041-1132.2004.04161.x