Výsledky vyhledávání - "Jonathan G. Bilmen"

Autor: Jonathan G. Bilmen

Publikováno v: British Journal of Anaesthesia. 125:637-638

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc868e702da9acc732c3643657e64c35
https://doi.org/10.1016/j.bja.2020.06.035

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Malignant hyperthermia

Autor: Philip M, Hopkins, Pawan K, Gupta, Jonathan G, Bilmen

Publikováno v: Handbook of clinical neurology. 157

Malignant hyperthermia (MH) is a form of heat illness caused by increased heat generation exceeding the body's capacity for heat loss. It is classified separately from other forms of heat illness as the latter require assessment of mental function fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::923977a1c09ab4e12aa9882f90dd3879
https://pubmed.ncbi.nlm.nih.gov/30459030

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The inhibition of the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase by macrocyclic lactones and cyclosporin A

Autor: Laura L. Wootton, Jonathan G. Bilmen, Francesco Michelangeli

Publikováno v: Biochemical Journal. 366:255-263

The pharmacology of macrocyclic lactones is varied, with many beneficial effects in treating disease processes. FK-506, rapamycin and ascomycin have been utilized as immunosuppressant agents. Ivermectin is typically used to treat parasitic worm infec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1da4ca8f5f6ac6bf05befd8b6f5d2c01
https://doi.org/10.1042/bj20020431

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Curcumin: a new cell-permeant inhibitor of the inositol 1,4,5-trisphosphate receptor

Autor: Jonathan G. Bilmen, S. Zafar Khan, M.-ul-H. Javed, Stuart R. Hawtin, Francesco Michelangeli, Mark Wheatley, Jeanette L. Dyer

Publikováno v: Cell Calcium. 31:45-52

Curcumin (diferuoylmethane or 1,7-bis (4-hydroxy-3-methoxyphenol)-1,6-hepatadiene-3,5-dione) is the active ingredient of the spice turmeric. Curcumin has been shown to have a number of pharmacological and therapeutic uses. This study shows that curcu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8931f6be6a949c4d414731bed9941f97
https://doi.org/10.1054/ceca.2001.0259

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Inhibition of the SERCA Ca2+ pumps by curcumin

Autor: Masood‐ul‐Hassan Javed, Shahla Zafar Khan, Francesco Michelangeli, Jonathan G. Bilmen

Publikováno v: European Journal of Biochemistry. 268:6318-6327

Curcumin is a compound derived from the spice, tumeric. It is a potent inhibitor of the SERCA Ca2+ pumps (all isoforms), inhibiting Ca2+-dependent ATPase activity with IC50 values of between 7 and 15 microm. It also inhibits ATP-dependent Ca2+-uptake

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21127e7f3bdc2c8a602e7be7ce86263c
https://doi.org/10.1046/j.0014-2956.2001.02589.x

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Estrogenic Alkylphenols Induce Cell Death by Inhibiting Testis Endoplasmic Reticulum Ca2+ Pumps

Autor: Rita E. Godfrey, S Z Kahn, P. J. Hughes, Robert H. Michell, Jonathan G. Bilmen, Damon A. Lowes, Stephen C. Tovey, Christopher J. Kirk, H. McLELLAN, Francesco Michelangeli

Publikováno v: Biochemical and Biophysical Research Communications. 277:568-574

Industrial alkylphenols in the environment may act as "xenoestrogens" to disrupt testicular development and decrease male fertility. Amongst possible targets for these compounds are testicular Sertoli cells, which nurture the developing sperm cells.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2244eaa539b5e5d2b5124c43f3f9ebc
https://doi.org/10.1006/bbrc.2000.3710

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Inhibition of SERCA Ca2+ pumps by 2-aminoethoxydiphenyl borate (2-APB). 2-APB reduces both Ca2+ binding and phosphoryl transfer from ATP, by interfering with the pathway leading to the Ca2+-binding sites

Autor: Rita E. Godfrey, Laura L. Wootton, Jonathan G. Bilmen, Oliver S. Smart, Francesco Michelangeli

Publikováno v: European journal of biochemistry. 269(15)

2-Aminoethoxydiphenyl Borate (2-APB) has been extensively used recently as a membrane permeable modulator of inositol-1,4,5-trisphosphate-sensitive Ca2+ channels and store-operated Ca2+ entry. Here, we report that 2-APB is also an inhibitor of sarco/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e23480e945e6579c2b3fae0c0c3e582
https://pubmed.ncbi.nlm.nih.gov/12153564

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Subtype identification and functional properties of inositol 1,4, 5-trisphosphate receptors in heart and aorta

Autor: Jeanette L. Dyer, Shahla Zafar Khan, Stephen C. Tovey, Mokdad Mezna, Rita E. Godfrey, Francesco Michelangeli, Jonathan G. Bilmen

Publikováno v: Pharmacological research. 42(6)

One of the major mechanisms by which hormones elevate intracellular Ca 2+ levels is by generating the second messenger inositol 1,4,5-trisphosphate (InsP 3 ), which activates a Ca 2+ channel (InsP 3 receptor) located in the endoplasmic reticulum (ER)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75858a386853c789f040aa15e3788359
https://pubmed.ncbi.nlm.nih.gov/11058412

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