Fracture in Living Cell Monolayers

Autor: Julia Duque, Alessandra Bonfanti, Jonathan Fouchard, Emma Ferber, Andrew Harris, Alexandre J. Kabla, Guillaume T. Charras

The ability of tissues to sustain mechanical stress and avoid fracture is a fundamental pillar of their function. Fracture in response to physiological levels of stress can be undesired, for example resulting from disease or genetic mutations, or be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a39bf0dfb3ae00ca7580e00478ef3797
https://doi.org/10.1101/2023.01.05.522736

How dynamic prestress governs the shape of living systems, from the subcellular to tissue scale

Autor: Alexander Erlich, Jocelyn Étienne, Jonathan Fouchard, Tom Wyatt

Publikováno v: Interface Focus. 12

Cells and tissues change shape both to carry out their function and during pathology. In most cases, these deformations are driven from within the systems themselves. This is permitted by a range of molecular actors, such as active crosslinkers and i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d328657527f80e409122c4dc42a86119
https://doi.org/10.1098/rsfs.2022.0038

Stress relaxation in epithelial monolayers is controlled by actomyosin

Autor: Buzz Baum, José J. Muñoz, Jonathan Fouchard, Andrew R. Harris, Amina Yonis, Alexandre Kabla, Guillaume Charras, Nina Asadipour, Yasuyuki Fujita, Payman Mosaffa, Mark Miodownik, Nargess Khalilgharibi

Epithelial monolayers are one-cell thick tissue sheets that separate internal and external environments. As part of their function, they withstand extrinsic mechanical stresses applied at high strain rate. However, little is known about how monolayer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::390ffe7e46f026f9daa7219951adc23f
https://doi.org/10.1101/302158

Three-dimensional cell body shape dictates the onset of traction force generation and growth of focal adhesions

Autor: Alain Richert, Nathalie Bufi, Olivier Cardoso, Pauline Durand-Smet, Amsha Proag, Célian Bimbard, Atef Asnacios, Jonathan Fouchard

Publikováno v: Proceedings of the National Academy of Sciences. 111:13075-13080

Cell shape affects proliferation and differentiation, which are processes known to depend on integrin-based focal adhesion (FA) signaling. Because shape results from force balance and FAs are mechanosensitive complexes transmitting tension from the c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e36da858f4211b159c7d0c72369befd0
https://doi.org/10.1073/pnas.1411785111

Cells as liquid motors: Mechanosensitivity emerges from collective dynamics of actomyosin cortex

Autor: Pauline Durand-Smet, Démosthène Mitrossilis, Nathalie Bufi, Atef Asnacios, Jonathan Fouchard, Jocelyn Etienne

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2015, 112 (9), pp.2740-2745. ⟨10.1073/pnas.1417113112⟩

International audience; Living cells adapt and respond actively to the mechanical properties of their environment. In addition to biochemical mechanotransduction, evidence exists for a myosin-dependent purely mechanical sensitivity to the stiffness o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b76c27d6d5c7139900566310449fdb9
https://europepmc.org/articles/PMC4352826/