Premature senescence of the liver in Alagille patients.

Autor: Giulia Jannone, Catherine de Magnée, Roberto Tambucci, Jonathan Evraerts, Joachim Ravau, Mustapha Najimi, Etienne Marc Sokal

Publikováno v: PLoS ONE, Vol 18, Iss 4, p e0285019 (2023)

IntroductionAlagille syndrome (ALGS) is an autosomal dominant disease characterized by a multisystem involvement including bile duct paucity and cholestasis, caused by JAG1 or NOTCH2 mutations in most of the cases. Jagged1-Notch2 interactions are kno

Externí odkaz: https://doaj.org/article/505a31a98014439c86c07b0a161bd253

Human liver mesenchymal stem/progenitor cells inhibit hepatic stellate cell activation: in vitro and in vivo evaluation

Autor: Mustapha Najimi, Silvia Berardis, Hoda El-Kehdy, Valérie Rosseels, Jonathan Evraerts, Catherine Lombard, Adil El Taghdouini, Patrick Henriet, Leo van Grunsven, Etienne Marc Sokal

Publikováno v: Stem Cell Research & Therapy, Vol 8, Iss 1, Pp 1-11 (2017)

Abstract Background Progressive liver fibrosis leads to cirrhosis and end-stage liver disease. This disease is a consequence of strong interactions between matrix-producing hepatic stellate cells (HSCs) and resident and infiltrating immune cell popul

Externí odkaz: https://doaj.org/article/2fbd8e2e98154697a864a3306c4110af

Gene expression profiling and secretome analysis differentiate adult-derived human liver stem/progenitor cells and human hepatic stellate cells.

Autor: Silvia Berardis, Catherine Lombard, Jonathan Evraerts, Adil El Taghdouini, Valérie Rosseels, Pau Sancho-Bru, Juan Jose Lozano, Leo van Grunsven, Etienne Sokal, Mustapha Najimi

Publikováno v: PLoS ONE, Vol 9, Iss 1, p e86137 (2014)

Adult-derived human liver stem/progenitor cells (ADHLSC) are obtained after primary culture of the liver parenchymal fraction. The cells are of fibroblastic morphology and exhibit a hepato-mesenchymal phenotype. Hepatic stellate cells (HSC) derived f

Externí odkaz: https://doaj.org/article/073f7dde1b56455abe511c955f5065ed

High Dose Versus Low Dose Syngeneic Hepatocyte Transplantation in Pex1-G844D NMRI Mouse Model is Safe but Does Not Achieve Long Term Engraftment

Autor: Mustapha Najimi, Etienne Sokal, Martin Roumain, Tanguy Demaret, Joachim Ravau, Giulio G. Muccioli, Jonathan Evraerts

Publikováno v: Cells
Volume 10
Issue 1
Cells, Vol 10, Iss 40, p 40 (2021)

Genetic alterations in PEX genes lead to peroxisome biogenesis disorder. In humans, they are associated with Zellweger spectrum disorders (ZSD). No validated treatment has been shown to modify the dismal natural history of ZSD. Liver transplantation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d9d65e352cbbd20acba72c56e767645
https://doi.org/10.3390/cells10010040

The Transcription Factor 7-Like 2-Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Axis Connects Mitochondrial Biogenesis and Metabolic Shift with Stem Cell Commitment to Hepatic Differentiation

Autor: Mehdi Najar, Patricia Renard, Marino Caruso, Etienne Sokal, Nicki Tiffin, Jean-Baka Domelevo Entfellner, Hoda El-Kehdy, Jonathan Evraerts, Guillaume Pourcher, Thierry Arnould, Catherine Demazy, Antoine Fattaccioli, Anaïs Wanet, Mustapha Najimi

Publikováno v: Wanet, A, Caruso, M, Domelevo Entfellner, J B, Najar, M, Fattaccioli, A, Demazy, C, Evraerts, J, El-Kehdy, H, Pourcher, G, Sokal, E, Arnould, T, Tiffin, N, Najimi, M & Renard, P 2017, ' The Transcription Factor 7-Like 2-Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Axis Connects Mitochondrial Biogenesis and Metabolic Shift with Stem Cell Commitment to Hepatic Differentiation ', Stem Cells, vol. 35, no. 10, 35(10), pp. 2184-2197 . https://doi.org/10.1002/stem.2688

Increasing evidence supports that modifications in the mitochondrial content, oxidative phosphorylation (OXPHOS) activity, and cell metabolism influence the fate of stem cells. However, the regulators involved in the crosstalk between mitochondria an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b4ae13efd66a75eff82febb12a7fb11
https://pubmed.ncbi.nlm.nih.gov/28795454