Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jonathan Elie"'
Autor:
Abdelaziz Ejjoummany, Jonathan Elie, Ahmed El Hakmaoui, Mohamed Akssira, Sylvain Routier, Frédéric Buron
Publikováno v:
Molecules, Vol 28, Iss 15, p 5811 (2023)
The first access to polyfunctionnalized pyrrolo[3,4-c]pyrazole-4,6-(2H,5H)-dione derivatives is reported. The series were generated from diethyl acetylenedicarboxylate and arylhydrazines, which afforded the key intermediates bearing two functional po
Externí odkaz:
https://doaj.org/article/6b1ba39ed39647edb1304684d8e99b07
Autor:
Chandra L. Shrestha, Shuzhong Zhang, Benjamin Wisniewski, Stephanie Häfner, Jonathan Elie, Laurent Meijer, Benjamin T. Kopp
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Abstract Cystic fibrosis (CF) is characterized by chronic bacterial infections and heightened inflammation. Widespread ineffective antibiotic use has led to increased isolation of drug resistant bacterial strains from respiratory samples. (R)-roscovi
Externí odkaz:
https://doaj.org/article/b28faafa018e4d7a8701559c160e0ad9
Autor:
Jonathan Elie, Omid Feizbakhsh, Nathalie Desban, Béatrice Josselin, Blandine Baratte, Amandine Bescond, Julien Duez, Xavier Fant, Stéphane Bach, Dominique Marie, Matthieu Place, Sami Ben Salah, Agnes Chartier, Sabine Berteina-Raboin, Apirat Chaikuad, Stefan Knapp, Fabrice Carles, Pascal Bonnet, Frédéric Buron, Sylvain Routier, Sandrine Ruchaud
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1840-1853 (2020)
Haspin is a mitotic protein kinase required for proper cell division by modulating Aurora B kinase localisation and activity as well as histone phosphorylation. Here a series of imidazopyridazines based on the CHR-6494 and Structure Activity Relation
Externí odkaz:
https://doaj.org/article/090287ce3ba04ea5ab8ef21466f6dc6b
Autor:
Jonathan Elie, Johnny Vercouillie, Nicolas Arlicot, Lucas Lemaire, Rudy Bidault, Sylvie Bodard, Christel Hosselet, Jean-Bernard Deloye, Sylvie Chalon, Patrick Emond, Denis Guilloteau, Frédéric Buron, Sylvain Routier
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1-7 (2019)
A series of novel derivatives exhibiting high affinity and selectivity towards the COX-2 enzyme in the (aza) indazole series was developed. A short synthetic route involving a bromination/arylation sequence under microwave irradiation and direct C–
Externí odkaz:
https://doaj.org/article/e9cfd14b1cb34e65971969a050ec7b00
Publikováno v:
Molecules, Vol 26, Iss 12, p 3540 (2021)
This paper reports a convenient sequential one-pot approach for the synthesis of an array of 14 pyrazolo[1,5-a][1,3,5]triazines, substituted in C8 by halogen (Br), various functions (CN and CO2Et) and alkyl or (het)aryl groups. This study confirms th
Externí odkaz:
https://doaj.org/article/946041da85e945e48f5d8fc6114f67cc
Publikováno v:
Journal of Epileptology, Vol 29, Iss i_current (2021)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87d751ff923c082388c0183644c22534
https://doi.org/10.21307/jepil-2021-002
https://doi.org/10.21307/jepil-2021-002
Autor:
Priyanka Gupta, Keehn Strange, Rahul Telange, Ailan Guo, Heather Hatch, Amin Sobh, Jonathan Elie, Angela M. Carter, John Totenhagen, Chunfeng Tan, Yogesh A. Sonawane, Jiri Neuzil, Amarnath Natarajan, Ashley J. Ovens, Jonathan S. Oakhill, Thorsten Wiederhold, Karel Pacak, Hans K. Ghayee, Laurent Meijer, Sushanth Reddy, James A. Bibb
Publikováno v:
Cell Rep
SUMMARYMetabolic dysfunction mutations can impair energy sensing and cause cancer. Loss of function of mitochondrial TCA cycle enzyme, succinate dehydrogenase B (SDHB) results in various forms of cancer typified by pheochromocytoma (PC). Here we deli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd56e70ddf59494d8509fea21a0a5641
https://doi.org/10.2139/ssrn.4018612
https://doi.org/10.2139/ssrn.4018612
Publikováno v:
Neurology, Psychiatry and Brain Research. 32:14-21
Introduction Controversy persists as to whether there exists a bioendogenous and/or socioculturally determined male overprevalence and/or a predominantly female neurological protective effect against occurrence of autism but with greater brain morbid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c63baf5890e70c077dfde66bce9a42d
https://doi.org/10.1016/j.npbr.2019.03.003
https://doi.org/10.1016/j.npbr.2019.03.003
Autor:
Patrick Emond, Jean-Bernard Deloye, Jonathan Elie, Denis Guilloteau, Frédéric Buron, Rudy Bidault, Sylvain Routier, Sylvie Bodard, Nicolas Arlicot, Christel Hosselet, Lucas Lemaire, Sylvie Chalon, Johnny Vercouillie
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1-7 (2019)
Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry
A series of novel derivatives exhibiting high affinity and selectivity towards the COX-2 enzyme in the (aza) indazole series was developed. A short synthetic route involving a bromination/arylation sequence under microwave irradiation and direct C–
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9348c93b6251912c0c13e8cc268c6611
https://doaj.org/article/e9cfd14b1cb34e65971969a050ec7b00
https://doaj.org/article/e9cfd14b1cb34e65971969a050ec7b00
Publikováno v:
Molecules
Volume 26
Issue 12
Molecules, Vol 26, Iss 3540, p 3540 (2021)
Volume 26
Issue 12
Molecules, Vol 26, Iss 3540, p 3540 (2021)
This paper reports a convenient sequential one-pot approach for the synthesis of an array of 14 pyrazolo[1,5-a][1,3,5]triazines, substituted in C8 by halogen (Br), various functions (CN and CO2Et) and alkyl or (het)aryl groups. This study confirms th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61876277f370cffba7c154f82a8ed831
https://pubmed.ncbi.nlm.nih.gov/34200623
https://pubmed.ncbi.nlm.nih.gov/34200623