Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Jonathan E. Nuss"'
Autor:
M. Jane Morwitzer, Sarah R. Tritsch, Lisa H. Cazares, Michael D. Ward, Jonathan E. Nuss, Sina Bavari, St Patrick Reid
Publikováno v:
Viruses, Vol 11, Iss 4, p 372 (2019)
Ebola virus (EBOV) is a filovirus that has become a global public health threat in recent years. EBOV is the causative agent of a severe, often fatal hemorrhagic fever. A productive viral infection relies on the successful recruitment of host factors
Externí odkaz:
https://doaj.org/article/4c08133f158c4f1c912aae0ac93b8b86
Autor:
Sina Bavari, Cary J. Retterer, Edna Torres-Melendez, Sarah J. Sandwick, Laura M. Wanner, Lyal E. Tressler, Jonathan E. Nuss, Gordon Ruthel, James C. Burnett
Publikováno v:
Toxins, Vol 3, Iss 3, Pp 207-217 (2011)
Botulinum neurotoxins (BoNTs) comprise seven distinct serotypes that inhibit the release of neurotransmitter across neuromuscular junctions, resulting in potentially fatal flaccid paralysis. BoNT serotype A (BoNT/A), which targets synaptosomal-associ
Externí odkaz:
https://doaj.org/article/9870667b3dd6453db0a5f49a6ad142f7
Autor:
Sina Bavari, Sarah R. Tritsch, Lisa H. Cazares, St Patrick Reid, Jonathan E. Nuss, Michael D. Ward, M. Jane Morwitzer
Publikováno v:
Viruses
Volume 11
Issue 4
Viruses, Vol 11, Iss 4, p 372 (2019)
Volume 11
Issue 4
Viruses, Vol 11, Iss 4, p 372 (2019)
Ebola virus (EBOV) is a filovirus that has become a global public health threat in recent years. EBOV is the causative agent of a severe, often fatal hemorrhagic fever. A productive viral infection relies on the successful recruitment of host factors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daefd12ac754cd1c20a55caf80baea29
Autor:
Stuart T. Nichol, Brett P. Eaton, Nate Larson, Ginger Donnelly, Mike Flint, Robert Jordan, Douglas L. Mayers, Michel Perron, Yeojin Park, Dustin Siegel, Lydia Wolfe, Veronica Soloveva, Edward Doerffler, William A. Lee, Donald K. Nichols, Dima N. Gharaibeh, Elizabeth C. Grimes, Laura Gomba, Darius Babusis, Travis K. Warren, Kwon Soo Chun, Tomas Cihlar, Queenie Wang, Adrian S. Ray, Kirsten M. Stray, Bruce Ross, Elyse R. Nagle, Kelly S. Stuthman, Lisa S. Welch, Rachel Fearns, Jonathan E. Nuss, Willard Lew, Jeffrey R. Kugelman, Molly R. Braun, Roy Bannister, Richard L. Mackman, Pamela Wong, Christina F. Spiropoulou, Joy Y. Feng, Hui Hon Chung, Ona Barauskas, Sean Neville, Jay Wells, Robert G. Strickley, Catherine L. Wilhelmsen, S. Swaminathan, Iva Trancheva, Nicole L. Garza, Cary Retterer, Michael K. Lo, Sean A. Van Tongeren, Gustavo Palacios, Laura K. McMullan, Amy C. Shurtleff, Lijun Zhang, Michael O. Clarke, Yili Xu, Sina Bavari, Tara Kenny, Ernest Carra, Rouzbeh Zamani, Shan Shan Chen
Publikováno v:
Nature
The most recent Ebola virus outbreak in West Africa, which was unprecedented in the number of cases and fatalities, geographic distribution, and number of nations affected, highlights the need for safe, effective, and readily available antiviral agen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::766327a9b5d4cc0d2298b57ff34377c6
http://europepmc.org/articles/PMC5551389
http://europepmc.org/articles/PMC5551389
Autor:
Lino Tessarollo, Krishna P. Kota, James C. Burnett, Hao T. Du, Rekha G. Panchal, Jonathan E. Nuss, Brian D. Peyser, Laura M. Wanner, Glenn Y. Gomba, Erkan Kiris, Rick Gussio, Christopher D. Kane, Sina Bavari
Publikováno v:
Neurotoxicity Research. 27:384-398
Botulinum neurotoxins (BoNTs), the causative agents of botulism, are potent inhibitors of neurotransmitter release from motor neurons. There are currently no drugs to treat BoNT intoxication after the onset of the disease symptoms. In this study, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f38adaa5adbb8ab11f1aae387bd391b
https://doi.org/10.1007/s12640-015-9526-z
https://doi.org/10.1007/s12640-015-9526-z
Autor:
Veronica Soloveva, Travis K. Warren, Carol Epstein, Jonathan E. Nuss, Robert Lenk, Ginger Donnelly, Lian Dong, Li Fang Liang, Thomas M. Bocan, Jay Wells, Kelly S. Wetzel, Dennis Giesing, Nicole L. Garza, Lisa H. Cazares, Keith A. Koistinen, Sina Bavari, Sean A. Van Tongeren, Lisa S. Welch, Sandra L. Bixler
Publikováno v:
Antiviral research. 151
Favipiravir is a broad-spectrum antiviral agent that has demonstrated efficacy against Ebola virus (EBOV) in rodents. However, there are no published reports of favipiravir efficacy for filovirus infection of nonhuman primates (NHPs). Here we evaluat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e61c9e128143942aa9a3091192a342cb
https://pubmed.ncbi.nlm.nih.gov/29289666
https://pubmed.ncbi.nlm.nih.gov/29289666
Autor:
Richard J. Sciotti, Milica Videnović, Dejan Opsenica, Mario Zlatović, Maja Krstic, Jonathan E. Nuss, Sandra Šegan, Sina Bavari, Života Selaković, Bogdan A. Šolaja, Jelena Konstantinović, Laura Gomba, James C. Burnett
Publikováno v:
Journal of Medicinal Chemistry
Significantly more potent second generation 4-amino-7-chloroquinoline (4,7-ACQ) based inhibitors of the botulinum neurotoxin serotype A (BoNT/A) light chain were synthesized. Introducing an amino group at the C(3) position of the cholate component ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35b223c485fa2421ac72bbde169db085
http://europepmc.org/articles/PMC4032193
http://europepmc.org/articles/PMC4032193
Autor:
Trevor Glaros, Karen A. Martins, Jonathan E. Nuss, Paul S. Demond, Michael D. Ward, Tara Kenny, Sina Bavari, Lisa H. Cazares, Christopher R. Mahone, Ernst E. Brueggemann
Publikováno v:
Clinical Proteomics
Background Ebola virus like particles (EBOV VLPs, eVLPs), are produced by expressing the viral transmembrane glycoprotein (GP) and structural matrix protein VP40 in mammalian cells. When expressed, these proteins self-assemble and bud from ‘host’
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d98f2fa71bff42df77fcd58a8a10bc04
https://doi.org/10.1186/s12014-016-9119-8
https://doi.org/10.1186/s12014-016-9119-8
Autor:
Sina Bavari, Ramdas Pai, Terry L. Bowlin, Norton P. Peet, Bing Li, Michelle M. Butler, Jonathan E. Nuss, Steven C. Cardinale
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:7338-7348
Botulinum neurotoxins (BoNTs) are the most lethal of biological substances, and are categorized as class A biothreat agents by the Centers for Disease Control and Prevention. There are currently no drugs to treat the deadly flaccid paralysis resultin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bae1c72f6b572ee84da4e46396e106e
https://doi.org/10.1016/j.bmc.2011.10.062
https://doi.org/10.1016/j.bmc.2011.10.062
Publikováno v:
SLAS Discovery. 15:928-936
Botulism, the disease caused by botulinum neurotoxins (BoNTs), secreted by the spore-forming, anaerobic bacteria Clostridium botulinum, has been associated with food poisoning for centuries. In addition, the potency of BoNTs coupled with the current
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76fe914326c91d0eb0e383cb7db8dbb3
https://doi.org/10.1177/1087057110374996
https://doi.org/10.1177/1087057110374996