Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Jonathan E Phillips"'
Autor:
Jonathan E Phillips, Duojia Pan
Publikováno v:
eLife, Vol 12 (2024)
The genomes of close unicellular relatives of animals encode orthologs of many genes that regulate animal development. However, little is known about the function of such genes in unicellular organisms or the evolutionary process by which these genes
Externí odkaz:
https://doaj.org/article/36872e03c4d84495a06088bea0c5a883
Publikováno v:
eLife, Vol 11 (2022)
Animal development is mediated by a surprisingly small set of canonical signaling pathways such as Wnt, Hedgehog, TGF-beta, Notch, and Hippo pathways. Although once thought to be present only in animals, recent genome sequencing has revealed componen
Externí odkaz:
https://doaj.org/article/c63fdfad2f4343108a6b466402f5a881
Autor:
Jonathan E Phillips, Richard H Gomer
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96633 (2014)
In Dictyostelium discoideum, the secreted proteins AprA and CfaD function as reporters of cell density and regulate cell number by inhibiting proliferation at high cell densities. AprA also functions to disperse groups of cells at high density by act
Externí odkaz:
https://doaj.org/article/c5f123763e5549e7b9935350e9b9505b
Autor:
Ruoqi Peng, Sriram Sridhar, Gaurav Tyagi, Jonathan E Phillips, Rosario Garrido, Paul Harris, Lisa Burns, Lorena Renteria, John Woods, Leena Chen, John Allard, Palanikumar Ravindran, Hans Bitter, Zhenmin Liang, Cory M Hogaboam, Chris Kitson, David C Budd, Jay S Fine, Carla M T Bauer, Christopher S Stevenson
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e59348 (2013)
The preclinical model of bleomycin-induced lung fibrosis, used to investigate mechanisms related to idiopathic pulmonary fibrosis (IPF), has incorrectly predicted efficacy for several candidate compounds suggesting that it may be of limited value. As
Externí odkaz:
https://doaj.org/article/f1de7e184b004255ba62f718b13adc00
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e21765 (2011)
The secreted proteins AprA and CfaD function as autocrine signals that inhibit cell proliferation in Dictyostelium discoideum, thereby regulating cell numbers by a negative feedback mechanism. We report here that the putative basic leucine zipper tra
Externí odkaz:
https://doaj.org/article/5c23577d05d64e6e9fd77cc6d6eb343b
Publikováno v:
Assay and Drug Development Technologies
The calcium-activated chloride channel, TMEM16A, is involved in airway hydration and bronchoconstriction and is a promising target for respiratory disease. Drug development efforts around channels require an electrophysiology-based assay for identify
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f75a2ffd8e3b026463b96fb9449f2256
http://europepmc.org/articles/PMC7268545
http://europepmc.org/articles/PMC7268545
Autor:
Seon-Cheol Park, Narongkorn Saiphoklang, Donghyun Jung, David Gomez, Jonathan E. Phillips, Brett A. Dolezal, Donald P. Tashkin, Igor Barjaktarevic, Christopher B. Cooper
Publikováno v:
Sensors; Volume 22; Issue 6; Pages: 2264
The purpose of this study was to explore the relationships between heart rate variability (HRV) and various phenotypic measures that relate to health and functional status in chronic obstructive pulmonary disease (COPD), and secondly, to demonstrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e81c933d0f29d72aa424920ee86914d
https://pubmed.ncbi.nlm.nih.gov/35336436
https://pubmed.ncbi.nlm.nih.gov/35336436
Animal development is mediated by a surprisingly small set of canonical signaling pathways such as Wnt, Hedgehog, TGF-beta, Notch and Hippo pathways. Although once thought to be present only in animals, recent genome sequencing has revealed component
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ff79311bd8aa0a2549efe0a4d4d88d7
https://doi.org/10.1101/2021.11.15.468130
https://doi.org/10.1101/2021.11.15.468130
Autor:
Jonathan E. Phillips, Ruoqi Peng, Lisa Burns, Paul Harris, Rosario Garrido, Gaurav Tyagi, Jay S. Fine, Christopher S. Stevenson
Publikováno v:
Pulmonary Pharmacology & Therapeutics. :102122
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f01dd3299f8ff8596eb95d9c2ea1f2a
https://doi.org/10.1016/j.pupt.2022.102122
https://doi.org/10.1016/j.pupt.2022.102122