Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Jonathan E Allen"'
Autor:
Monica K Borucki, Nicole M Collette, Lark L Coffey, Koen K A Van Rompay, Mona H Hwang, James B Thissen, Jonathan E Allen, Adam T Zemla
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0225699 (2019)
The question of how Zika virus (ZIKV) changed from a seemingly mild virus to a human pathogen capable of microcephaly and sexual transmission remains unanswered. The unexpected emergence of ZIKV's pathogenicity and capacity for sexual transmission ma
Externí odkaz:
https://doaj.org/article/32215a92c06240919b223940e2a426ee
Autor:
James B Thissen, Mariko Isshiki, Crystal Jaing, Yoshiro Nagao, Dayanara Lebron Aldea, Jonathan E Allen, Masafumi Izui, Thomas R Slezak, Takafumi Ishida, Tetsuya Sano
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0209683 (2018)
Kawasaki disease (KD), first identified in 1967, is a pediatric vasculitis of unknown etiology that has an increasing incidence in Japan and many other countries. KD can cause coronary artery aneurysms. Its epidemiological characteristics, such as se
Externí odkaz:
https://doaj.org/article/44ebb7dd5a194fd5b31e44759a5e397f
Autor:
Alison M Devault, Tatum D Mortimer, Andrew Kitchen, Henrike Kiesewetter, Jacob M Enk, G Brian Golding, John Southon, Melanie Kuch, Ana T Duggan, William Aylward, Shea N Gardner, Jonathan E Allen, Andrew M King, Gerard Wright, Makoto Kuroda, Kengo Kato, Derek EG Briggs, Gino Fornaciari, Edward C Holmes, Hendrik N Poinar, Caitlin S Pepperell
Publikováno v:
eLife, Vol 6 (2017)
Pregnancy complications are poorly represented in the archeological record, despite their importance in contemporary and ancient societies. While excavating a Byzantine cemetery in Troy, we discovered calcified abscesses among a woman’s remains. Sc
Externí odkaz:
https://doaj.org/article/903f8e15222549e489eb9945dff23dc4
Autor:
Monica K Borucki, Victoria Lao, Mona Hwang, Shea Gardner, Danielle Adney, Vincent Munster, Richard Bowen, Jonathan E Allen
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0154424 (2016)
[This corrects the article DOI: 10.1371/journal.pone.0146251.].
Externí odkaz:
https://doaj.org/article/6d55305fdc9e42e1b9dd6d94d85e804b
Autor:
Monica K Borucki, Victoria Lao, Mona Hwang, Shea Gardner, Danielle Adney, Vincent Munster, Richard Bowen, Jonathan E Allen
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146251 (2016)
Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging human pathogen related to SARS virus. In vitro studies indicate this virus may have a broad host range suggesting an increased pandemic potential. Genetic and epidemiological evid
Externí odkaz:
https://doaj.org/article/9e66fe4ab8e245dd8289a04955913c4e
Publikováno v:
Machine Learning and Knowledge Extraction, Vol 6, Iss 1, Pp 642-657 (2024)
Decades of drug development research have explored a vast chemical space for highly active compounds. The exponential growth of virtual libraries enables easy access to billions of synthesizable molecules. Computational modeling, particularly molecul
Externí odkaz:
https://doaj.org/article/7c9e6d013e0c4eb6b3837958e0a4348d
Autor:
Monica K Borucki, Haiyin Chen-Harris, Victoria Lao, Gilda Vanier, Debra A Wadford, Sharon Messenger, Jonathan E Allen
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 7, Iss 11, p e2555 (2013)
One of the hurdles to understanding the role of viral quasispecies in RNA virus cross-species transmission (CST) events is the need to analyze a densely sampled outbreak using deep sequencing in order to measure the amount of mutation occurring on a
Externí odkaz:
https://doaj.org/article/727521858c7a41028a7b99c9f054c340
The role of viral population diversity in adaptation of bovine coronavirus to new host environments.
Autor:
Monica K Borucki, Jonathan E Allen, Haiyin Chen-Harris, Adam Zemla, Gilda Vanier, Shalini Mabery, Clinton Torres, Pamela Hullinger, Tom Slezak
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e52752 (2013)
The high mutation rate of RNA viruses enables a diverse genetic population of viral genotypes to exist within a single infected host. In-host genetic diversity could better position the virus population to respond and adapt to a diverse array of sele
Externí odkaz:
https://doaj.org/article/2218073dd05540f79e9c8410960c680c
Autor:
Aram Avila-Herrera, Jeffrey A. Kimbrel, Jose Manuel Martí, James Thissen, Edwin A. Saada, Tracy Weisenberger, Kathryn T. Arrildt, Brent W. Segelke, Jonathan E. Allen, Adam Zemla, Monica K. Borucki
Publikováno v:
PLoS ONE, Vol 19, Iss 1 (2024)
Externí odkaz:
https://doaj.org/article/283b60b31d194f008d9dc05246724a1b
Autor:
Ya Ju Fan, Jonathan E. Allen, Kevin S. McLoughlin, Da Shi, Brian J. Bennion, Xiaohua Zhang, Felice C. Lightstone
Publikováno v:
Artificial Intelligence Chemistry, Vol 1, Iss 1, Pp 100004- (2023)
Neural Network (NN) models provide potential to speed up the drug discovery process and reduce its failure rates. The success of NN models requires uncertainty quantification (UQ) as drug discovery explores chemical space beyond the training data dis
Externí odkaz:
https://doaj.org/article/efcc644112614a30945cbc2b09c71d37