Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Jonathan Dickerhoff"'
Autor:
Hang Lin, Muhammad Hassan Safdar, Sarah Washburn, Saeed S. Akhand, Jonathan Dickerhoff, Mitchell Ayers, Marvis Monteiro, Luis Solorio, Danzhou Yang, Michael K. Wendt
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract Limiting cellular plasticity is of key importance for the therapeutic targeting of metastatic breast cancer (MBC). Fibroblast growth receptor (FGFR) is a critical molecule in cellular plasticity and potent inhibitors of FGFR enzymatic activi
Externí odkaz:
https://doaj.org/article/9627326e652d4cd584f63b914469081f
Publikováno v:
Engineering, Vol 38, Iss , Pp 39-51 (2024)
DNA guanine (G)-quadruplexes (G4s) are unique secondary structures formed by two or more stacked G-tetrads in G-rich DNA sequences. These structures have been found to play a crucial role in highly transcribed genes, especially in cancer-related onco
Externí odkaz:
https://doaj.org/article/758e276aab4243aba79bfbbf79874b32
Publikováno v:
ACS Omega, Vol 4, Iss 2, Pp 2533-2539 (2019)
Externí odkaz:
https://doaj.org/article/d0f45aae6a324a0fa9a72fc688888722
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 19, p 10801 (2021)
G-quadruplexes are four-stranded nucleic acid secondary structures of biological significance and have emerged as an attractive drug target. The G4 formed in the MYC promoter (MycG4) is one of the most studied small-molecule targets, and a model syst
Externí odkaz:
https://doaj.org/article/cd63912ba407456588f60159c11a8151
Publikováno v:
Molecules, Vol 26, Iss 14, p 4132 (2021)
This review is dedicated to Professor William A. Denny’s discovery of XR5944 (also known as MLN944). XR5944 is a DNA-targeted agent with exceptionally potent antitumor activity and a novel DNA binding mode, bis-intercalation and major groove bindin
Externí odkaz:
https://doaj.org/article/70d807c57be24335a4d92fdf981591e7
Publikováno v:
Accounts of Chemical Research. 55:2628-2646
ConspectusDNA G-quadruplex secondary structures formed in guanine-rich human telomeres and oncogene promoters are functionally important and have emerged as a promising new class of cancer-specific drug targets. These globular intramolecular structur
Publikováno v:
Handbook of Chemical Biology of Nucleic Acids ISBN: 9789811613135
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01ac30cb777284543c9fbf88b752de9a
https://doi.org/10.1007/978-981-16-1313-5_10-1
https://doi.org/10.1007/978-981-16-1313-5_10-1
Publikováno v:
J Med Chem
The medicinal natural product berberine is one of the most actively studied and pursued G-quadruplex (G4)-ligands. The major G-quadruplex formed in the promoter region of the MYC oncogene (MycG4) is an attractive drug target and a prominent example a
Publikováno v:
Cancer Research. 83:3840-3840
The transcription of the MYC oncogene, a central player of oncogenesis, is strongly controlled by DNA G-quadruplexes in its promoter region (MycG4). Stabilization of MycG4 with small molecules downregulates MYC expression and has devastating effects
Publikováno v:
Cancer Research. 83:3842-3842
PDGFR-β (Platelet-Derived Growth Factor Receptor beta) is a receptor tyrosine kinase whose overexpression drives the progression and metastasis of many cancers. It is an established anticancer target and PDGFR-β inhibition via kinase inhibitors has