Výsledky vyhledávání - "Jonathan D. Wood"

Akademický článek

Sonic hedgehog functions upstream of disrupted-in-schizophrenia 1 (disc1): implications for mental illness

Autor: Penelope J. Boyd, Vincent T. Cunliffe, Sudipto Roy, Jonathan D. Wood

Publikováno v: Biology Open, Vol 4, Iss 10, Pp 1336-1343 (2015)

DISRUPTED-IN-SCHIZOPHRENIA (DISC1) has been one of the most intensively studied genetic risk factors for mental illness since it was discovered through positional mapping of a translocation breakpoint in a large Scottish family where a balanced chrom

Externí odkaz: https://doaj.org/article/b727f10d6e9d4691a0b90f8b26e11591

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Akademický článek

Progressive phenotype and nuclear accumulation of an amino-terminal cleavage fragment in a transgenic mouse model with inducible expression of full-length mutant huntingtin

Autor: Yuji Tanaka, Shuichi Igarashi, Masayuki Nakamura, Juliette Gafni, Cameron Torcassi, Gabrielle Schilling, Danielle Crippen, Jonathan D. Wood, Akira Sawa, Nancy A. Jenkins, Neal G. Copeland, David R. Borchelt, Christopher A. Ross, Lisa M. Ellerby

Publikováno v: Neurobiology of Disease, Vol 21, Iss 2, Pp 381-391 (2006)

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder characterized behaviorally by chorea, incoordination, and shortened lifespan and neuropathologically by huntingtin inclusions and neuronal degeneration. In order to facilit

Externí odkaz: https://doaj.org/article/0f583253bf4e44ac933ae12f542f61b9

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Akademický článek

Distinct Behavioral and Neuropathological Abnormalities in Transgenic Mouse Models of HD and DRPLA

Autor: Gabriele Schilling, Hyder A. Jinnah, Vicky Gonzales, Michael L. Coonfield, Yujin Kim, Jonathan D. Wood, Donald L. Price, Xiao-Jiang Li, Nancy Jenkins, Neal Copeland, Timothy Moran, Christopher A. Ross, David R. Borchelt

Publikováno v: Neurobiology of Disease, Vol 8, Iss 3, Pp 405-418 (2001)

Huntington's disease (HD) and Dentatorubral and pallidoluysian atrophy (DRPLA) are autosomal dominant, neurodegenerative disorders caused by the expansion of polyglutamine tracts in their respective proteins, huntingtin and atrophin-1. We have previo

Externí odkaz: https://doaj.org/article/cbb632cb9c984806ad46071c59575f3c

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Elektronická kniha

A Closer Look at the United States Drug Enforcement Administration

Autor: Jonathan D. Wood

The mission of the Drug Enforcement Administration (DEA) is to enforce the controlled substances laws and regulations of the United States and bring to the criminal and civil justice system of the United States, or any other competent jurisdiction, t

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Oligodendrocyte pathology exceeds axonal pathology in white matter in human amyotrophic lateral sclerosis

Autor: Pamela J. Shaw, Johnathan Cooper-Knock, Adrian Higginbottom, Janine Kirby, Jonathan D. Wood, Ebtisam Al-ofi, Alejandro Lorente Pons, J. Robin Highley, Aziza Alrafiah

Publikováno v: Lorente Pons, A, Higginbottom, A, Cooper-Knock, J, Alrafiah, A, Alofi, E, Kirby, J, Shaw, P J, Wood, J D & Highley, J R 2020, ' Oligodendrocyte pathology exceeds axonal pathology in white matter in human amyotrophic lateral sclerosis ', Journal of Pathology . https://doi.org/10.1002/path.5455

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease. The majority of cases are sporadic (sALS), while the most common inherited form is due to C9orf72 mutation (C9ALS). A high burden of inclusion pathology is seen in glia (including ol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4d482a6df36217c0955f28663b5d9b0
https://pubmed.ncbi.nlm.nih.gov/32391572

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Antiretroviral therapy, interferon sensitivity, and virologic setpoint in human immunodeficiency virus/hepatitis C virus coinfected patients

Autor: Justin Richer, Lois Eldred, Jonathan D. Wood, Ashwin Balagopal, Yvonne H. Higgins, David L. Thomas, Stuart C. Ray, Mark S. Sulkowski, Zhiping Li, Jeffrey Quinn, Abraham J. Kandathil

Publikováno v: Hepatology. 60:477-486

Human immunodeficiency virus (HIV) and hepatitis C virus (HCV) cause substantial mortality, especially in persons chronically infected with both viruses. HIV infection raises plasma HCV RNA levels and diminishes the response to exogenous alpha interf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::42815c44f5b2e97847dbe3e98e8bc007
https://doi.org/10.1002/hep.27158

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Genetic and chemical modulation of spastin-dependent axon outgrowth in zebrafish embryos indicates a role for impaired microtubule dynamics in hereditary spastic paraplegia

Autor: Richard Butler, Jennifer A. Landers, Vincent T. Cunliffe, Jonathan D. Wood

Publikováno v: Disease Models & Mechanisms. 3:743-751

SUMMARY Mutations in the SPAST (SPG4) gene, which encodes the microtubule-severing protein spastin, are the most common cause of autosomal dominant hereditary spastic paraplegia (HSP). Following on from previous work in our laboratory showing that sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d77a5d32c4fa8ee71aac15797de21b20
https://doi.org/10.1242/dmm.004002

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Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients

Autor: Kurt J. De Vos, Andrew J. Grierson, Christopher C.J. Miller, Roy Milner, Jonathan D. Wood, Ellen J. Bennett, Paul R. Kasher, Stephen B. Wharton, Megan Bingley, Catherine Manser, Pamela J. Shaw, Christopher J McDermott

Publikováno v: Journal of Neurochemistry. 110:34-44

Mutations in spastin are the most common cause of hereditary spastic paraplegia (HSP) but the mechanisms by which mutant spastin induces disease are not clear. Spastin functions to regulate microtubule organisation, and because of the essential role

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b86658f83695054563834f0bdbabbf5
https://doi.org/10.1111/j.1471-4159.2009.06104.x

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Disrupted-in-schizophrenia 1 and neuregulin 1 are required for the specification of oligodendrocytes and neurones in the zebrafish brain

Autor: Vincent T. Cunliffe, Jonathan D. Wood, Franziska Bonath, Shashvita Kumar, Christopher A. Ross

Publikováno v: Human Molecular Genetics. 18:391-404

Schizophrenia may arise from subtle abnormalities in brain development due to alterations in the functions of candidate susceptibility genes such as Disrupted-in-schizophrenia 1 (DISC1) and Neuregulin 1 (NRG1). To provide novel insights into the func

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1c0594df0bdb24037d74890c96f53fe
https://doi.org/10.1093/hmg/ddn361

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Deficiency in the mRNA export mediator Gle1 impairs Schwann cell development in the zebrafish embryo

Autor: Basil Sharrack, H.R. Kim, Ke Ning, N.I. Alsomali, Jonathan D. Wood, Tennore Ramesh, Chiara F. Valori, A. Seytanoglu, Alan T McGown, Mimoun Azzouz

Publikováno v: Neuroscience 322, 287-297 (2016). doi:10.1016/j.neuroscience.2016.02.039

GLE1 mutations cause lethal congenital contracture syndrome 1 (LCCS1), a severe autosomal recessive fetal motor neuron disease, and more recently have been associated with amyotrophic lateral sclerosis (ALS). The gene encodes a highly conserved prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33e3ba3bbd9a53a989c0c5a753a43f3b
https://pubmed.ncbi.nlm.nih.gov/26921650

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