Výsledky vyhledávání - "Jonathan D. White"

VIPER is a genetically encoded peptide tag for fluorescence and electron microscopy

Autor: Kimberly E. Beatty, Jonathan D. White, Caroline A. Enns, Claudia S. López, Julia K. Doh, Young Hwan Chang, Hannah K. Zane

Many discoveries in cell biology rely on making specific proteins visible within their native cellular environment. There are various genetically encoded tags, such as fluorescent proteins, developed for fluorescence microscopy (FM). However, there a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8fb07cc3ff46831aa3433dd39539af9
https://europepmc.org/articles/PMC6304991/

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Multifunctional Pt(II) Reagents: Covalent Modifications of Pt Complexes Enable Diverse Structural Variation and In-Cell Detection

Autor: Victoria J. DeRose, Jonathan D. White, Michael M. Haley

Publikováno v: Accounts of Chemical Research. 49:56-66

To enhance the functionality of Pt-based reagents, several strategies have been developed that utilize Pt compounds modified with small, reactive handles. This Account encapsulates work done by us and other groups regarding the use of Pt(II) compound

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::022ebc31ae5ec9ce6b77d0b36daa3337
https://doi.org/10.1021/acs.accounts.5b00322

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Azide vs Alkyne Functionalization in Pt(II) Complexes for Post-treatment Click Modification: Solid-State Structure, Fluorescent Labeling, and Cellular Fate

Autor: Lev N. Zakharov, Jonathan D. White, Michael M. Haley, Victoria J. DeRose, Regina Wirth, Aurora L. Ginzburg, Alan D. Moghaddam

Publikováno v: Journal of the American Chemical Society. 137:15169-15175

Tracking of Pt(II) complexes is of crucial importance toward understanding Pt interactions with cellular biomolecules. Post-treatment fluorescent labeling of functionalized Pt(II)-based agents using the bioorthogonal Cu(I)-catalyzed azide-alkyne cycl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97bf2b54bb3f54d51129e67c22ea7fbe
https://doi.org/10.1021/jacs.5b09108

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Convenient detection of metal-DNA, metal-RNA, and metal-protein adducts with a click-modified Pt(II) complex

Autor: Michael M. Haley, Victoria J. DeRose, Jonathan D. White, Andrea N. Loes, Alan D. Moghaddam, Rachael M. Cunningham

Publikováno v: Dalton transactions (Cambridge, England : 2003). 44(8)

cis-[Pt(2-azido-1,3-propanediamine)Cl2] is a reagent for high-yield post-treatment fluorescent labelling of Pt(II) biomolecular targets using click chemistry and exhibits a bias in conformational isomers in the context of duplex DNA. Pt–protein add

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e5a9b4fe3324987ebe7851d6f2ab894
https://pubmed.ncbi.nlm.nih.gov/25338004

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An alkyne-appended, click-ready Pt(II) complex with an unusual arrangement in the solid state

Autor: Jonathan D. White, Michael M. Haley, Victoria J. DeRose, Lindsay E. Guzman, Lev N. Zakharov

Publikováno v: Angewandte Chemie (International ed. in English). 54(3)

To better understand the range of cellular interactions of Pt(II) -based chemotherapeutics, robust and efficient methods to track and analyze Pt targets are needed. A powerful approach is to functionalize Pt(II) compounds with alkyne or azide moietie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d7cb237317ab769f92c123bd4d1bc6a
https://pubmed.ncbi.nlm.nih.gov/25429919

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Platinum-RNA modifications following drug treatment in S. cerevisiae identified by click chemistry and enzymatic mapping

Autor: Jonathan D. White, Michael M. Haley, Victoria J. DeRose, Maire F. Osborn

Publikováno v: ACS Chemical Biology

With the importance of RNA-based regulatory pathways, the potential for targeting noncoding and coding RNAs by small molecule therapeutics is of great interest. Platinum(II) complexes including cisplatin (cis-diamminedichloroplatinum(II)) are widely

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6498958b311b5b519d20f00ec5d9cfc
https://pubmed.ncbi.nlm.nih.gov/25055168

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ChemInform Abstract: Picazoplatin, an Azide-Containing Platinum(II) Derivative for Target Analysis by Click Chemistry

Autor: Michael M. Haley, Alan D. Moghaddam, Victoria J. DeRose, Jonathan D. White, Lindsay E. Guzman, Maire F. Osborn

Publikováno v: ChemInform. 45

The new title compound (I) readily binds DNA and RNA oligonucleotides and undergoes facile post-labeling click reactions to alkyne—fluorophore conjugates.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ab45622ad75a81711203b58c5c3a4202
https://doi.org/10.1002/chin.201405195

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Picazoplatin, an Azide-Containing Platinum(II) Derivative for Target Analysis by Click Chemistry

Autor: Jonathan D. White, Maire F. Osborn, Victoria J. DeRose, Michael M. Haley, Lindsay E. Guzman, Alan D. Moghaddam

Despite the broad use of platinum-based chemotherapeutics, identification of their full range of cellular targets remains a significant challenge. In order to identify, visualize, and isolate cellular targets of Pt(II) complexes, we have modified the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc675a6ddd4bdbdf27891db9753e943b
https://europepmc.org/articles/PMC4130293/

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