Výsledky vyhledávání - "Jonathan D. Verrier"

Akademický článek

Intermittent fasting alleviates the neuropathic phenotype in a mouse model of Charcot–Marie–Tooth disease

Autor: Irina Madorsky, Katherine Opalach, Amanda Waber, Jonathan D. Verrier, Chelsea Solmo, Thomas Foster, William A. Dunn, Jr., Lucia Notterpek

Publikováno v: Neurobiology of Disease, Vol 34, Iss 1, Pp 146-154 (2009)

Charcot–Marie–Tooth type 1A (CMT1A) neuropathies linked to the misexpression of peripheral myelin protein 22 (PMP22) are progressive demyelinating disorders of the peripheral nervous system. In this study we asked whether dietary restriction by i

Externí odkaz: https://doaj.org/article/c693717a46f047e88685b0105c01cf0e

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Akademický článek

The formation of peripheral myelin protein 22 aggregates is hindered by the enhancement of autophagy and expression of cytoplasmic chaperones

Autor: Jenny Fortun, Jonathan D. Verrier, Jocelyn C. Go, Irina Madorsky, William A. Dunn, Lucia Notterpek

Publikováno v: Neurobiology of Disease, Vol 25, Iss 2, Pp 252-265 (2007)

The accumulation of misfolded proteins is associated with various neurodegenerative conditions. Peripheral myelin protein 22 (PMP22) is a hereditary neuropathy-linked, short-lived molecule that forms aggresomes when the proteasome is inhibited or the

Externí odkaz: https://doaj.org/article/16b4f5e3bbaf4bcbb2f92faa56d5d397

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Akademický článek

Bicistronic lentiviruses containing a viral 2A cleavage sequence reliably co-express two proteins and restore vision to an animal model of LCA1.

Autor: Jonathan D Verrier, Irina Madorsky, William E Coggin, Mero Geesey, Michael Hochman, Elleanor Walling, Daniel Daroszewski, Kristofer S Eccles, Rachel Ludlow, Susan L Semple-Rowland

Publikováno v: PLoS ONE, Vol 6, Iss 5, p e20553 (2011)

The disease processes underlying inherited retinal disease are complex and are not completely understood. Many of the corrective gene therapies designed to treat diseases linked to mutations in genes specifically expressed in photoreceptor cells rest

Externí odkaz: https://doaj.org/article/61545cf1e97247dba6c46820b34a538a

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Renal 2′,3′-Cyclic Nucleotide 3′-Phosphodiesterase Is an Important Determinant of AKI Severity after Ischemia-Reperfusion

Autor: Jonathan D. Verrier, Zaichuan Mi, Keri Janesko-Feldman, Elizabeth V. Menshikova, Rashmi Bansal, Patrick M. Kochanek, Edwin K. Jackson, Travis C. Jackson

Publikováno v: Journal of the American Society of Nephrology. 27:2069-2081

A positional isomer of 3',5'-cAMP, 2',3'-cAMP, is produced by kidneys in response to energy depletion, and renal 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) metabolizes 2',3'-cAMP to 2'-AMP; 2',3'-cAMP is a potent opener of mitochondrial pe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d458543c5f985fbbdbf1b6d47fe7f15c
https://doi.org/10.1681/asn.2015040397

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2′,3′-cAMP, 3′-AMP, 2′-AMP and adenosine inhibit TNF-α and CXCL10 production from activated primary murine microglia via A2A receptors

Autor: Delbert G. Gillespie, Jonathan D. Verrier, Travis C. Jackson, Elizabeth A. Newell, Patrick M. Kochanek, Keri Janesko-Feldman, Jennifer L. Exo, Edwin K. Jackson

Publikováno v: Brain Research. 1594:27-35

Background Some cells, tissues and organs release 2′,3′-cAMP (a positional isomer of 3′,5′-cAMP) and convert extracellular 2′,3′-cAMP to 2′-AMP plus 3′-AMP and convert these AMPs to adenosine (called the extracellular 2′,3′-cAMP-a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc7699c7b48d2ca4efbf0f01d1d3efbc
https://doi.org/10.1016/j.brainres.2014.10.059

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Pharmacological Inhibition of Pleckstrin Homology Domain Leucine-Rich Repeat Protein Phosphatase Is Neuroprotective: Differential Effects on Astrocytes

Autor: Delbert G. Gillespie, Thomas Uray, Tomas Drabek, Jonathan D. Verrier, Travis C. Jackson, Patrick M. Kochanek, Edwin K. Jackson, Hülya Bayır, Cameron Dezfulian, Keri Janesko-Feldman, Robert S. B. Clark

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 347:516-528

Pleckstrin homology domain and leucine-rich repeat protein phosphatase 1 (PHLPP1) inhibits protein kinase B (AKT) survival signaling in neurons. Small molecule pan-PHLPP inhibitors (selective for PHLPP1 and PHLPP2) may offer a translatable method to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5baf730920a504a656e5f1a7149d2edb
https://doi.org/10.1124/jpet.113.206888

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Role of CNPase in the oligodendrocytic extracellular 2′,3′-cAMP-adenosine pathway

Autor: Klaus-Armin Nave, Jonathan D. Verrier, Delbert G. Gillespie, Sandra Goebbels, Edwin K. Jackson, Keri Janesko-Feldman, Travis C. Jackson, Rashmi Bansal, Patrick M. Kochanek

Publikováno v: Glia. 61:1595-1606

Extracellular adenosine 3′,5′-cyclic monophosphate (3′,5′-cAMP) is an endogenous source of localized adenosine production in many organs. Recent studies suggest that extracellular 2′,3′-cAMP (positional isomer of 3′,5′-cAMP) is also a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::85249c10a32a21323f8a530109381690
https://doi.org/10.1002/glia.22523

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The brain in vivo expresses the 2′,3′-cAMP-adenosine pathway

Autor: Travis C. Jackson, David O. Okonkwo, Ava M. Puccio, Jonathan D. Verrier, Rashmi Bansal, Patrick M. Kochanek, Edwin K. Jackson

Publikováno v: Journal of Neurochemistry. 122:115-125

Although multiple biochemical pathways produce adenosine, studies suggest that the 2',3'-cAMP-adenosine pathway (2',3'-cAMP→2'-AMP/3'-AMP→adenosine) contributes to adenosine production in some cells/tissues/organs. To determine whether the 2',3'-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c50f689e62366fb062166d5f71913df
https://doi.org/10.1111/j.1471-4159.2012.07705.x

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