Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jonathan D. Trumbull"'
Autor:
David G. McKenna, Connie R. Faltynek, Char-Chang Shieh, Xu-Feng Zhang, Jay F. Sarthy, Jonathan D. Trumbull, Murali Gopalakrishnan, Ashutosh S. Parihar
Publikováno v:
ASSAY and Drug Development Technologies. 1:655-663
Ligand-gated ion channels (LGICs) play important roles in the regulation of cellular function and signaling and serve as excellent drug targets. However, fast desensitization of most LGICs limits the choice of reliable methods to identify agonists, a
Autor:
Jonathan D. Trumbull, Eugene S. Maslana, David G. Mckenna, Thomas A. Nemcek, Wende Niforatos, Jeffrey Y. Pan, Ashutosh S. Parihar, Char-Chang Shieh, Julie A. Wilkins, Clark A. Briggs, Daniel Bertrand
Publikováno v:
Receptors and Channels. 9:19-28
Autor:
David Sutherland, Jonathan D. Trumbull, Anil Vasudevan, Jeff Pan, Jeffrey A. Olson, Stevan W. Djuric, Villamil Clara I
Publikováno v:
Tetrahedron Letters. 51:4007-4009
A flow-through photochemical reactor which enables facile control of irradiation time, temperature, and wavelength with minimal manual intervention is described. A series of intramolecular [2+2] enone cycloadditions were performed in this reactor in
Publikováno v:
IEEE Transactions on Biomedical Engineering. 47:3-7
The philosophy of miniature total analysis systems (mu-TAS) hinges on the integration of multiple chemical processing steps and the means of analyzing their results on the same miniaturized system. We have constructed chip-based capillary electrophor
Autor:
Jeff Pan, Stevan W. Djuric, Anil Vasudevan, Jonathan D. Trumbull, Jeffrey A. Olson, Villamil Clara I, David Sutherland
Publikováno v:
ChemInform. 41
A microreactor allows continuous flow photoreactions under carefully controlled conditions.
Autor:
Kirsten Thorin-Hagene, Monika Håkerud, Daniel B. Timmermann, Clark A. Briggs, Philip K. Ahring, John Malysz, Yongli Xiong, Hilde Ween, Jens Halvard Grønlien, Jonathan D. Trumbull, Murali Gopalakrishnan, Tino Dyhring
Publikováno v:
Assay and drug development technologies. 7(4)
Neuronal acetylcholine receptors (nAChRs) of the alpha7 subtype are ligand-gated ion channels that are widely distributed throughout the central nervous system and considered as attractive targets for the treatment of various neuropsychiatric and neu
Autor:
Mark E. Schurdak, Lan Gao, Claude G. Lerner, Houjun Yang, Jonathan D. Trumbull, Hua Tang, David J. Burns, Xueheng Cheng, Bruce A. Beutel, J. Owen McCall, Michael L. Coen, Kenneth M. Comess, Martin J. Voorbach
Publikováno v:
Journal of biomolecular screening. 11(7)
The authors describe the discovery of a new class of inhibitors to an essential Streptococcus pneumoniae cell wall biosynthesis enzyme, MurF, by a novel affinity screening method. The strategy involved screening very large mixtures of diverse small o
Publikováno v:
Proceedings of the 20th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Vol.20 Biomedical Engineering Towards the Year 2000 and Beyond (Cat. No.98CH36286).
Miniaturized fluid systems have emerged in recent years as a serious approach to improved performance and new functionality in the bioanalysis arena. Several important scaling issues are important in the design of fluid systems at the micro scale inc
Publikováno v:
1998 Solid-State, Actuators, and Microsystems Workshop Technical Digest.
Autor:
John Malysz, Jens H. Grønlien, Daniel B. Timmermann, Monika Håkerud, Kirsten Thorin-Hagene, Hilde Ween, Jonathan D. Trumbull, Clark A. Briggs, Philip K. Ahring, Tino Dyhring, Murali Gopalakrishnan
Publikováno v:
Assay & Drug Development Technologies; Aug2009, Vol. 7 Issue 4, p374-390, 17p