Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Jonathan D. Steckbeck"'
Publikováno v:
Viruses, Vol 6, Iss 1, Pp 284-300 (2014)
Retroviruses are a family of viruses that cause a broad range of pathologies in animals and humans, from the apparently harmless, long-term genomic insertion of endogenous retroviruses, to tumors induced by the oncogenic retroviruses and acquired imm
Externí odkaz:
https://doaj.org/article/70a9be86f5db43858f7f1927e10288f0
Autor:
David B Huang, Kimberly M Brothers, Jonathan B Mandell, Masashi Taguchi, Peter G Alexander, Dana M Parker, Dean Shinabarger, Chris Pillar, Ian Morrissey, Stephen Hawser, Parviz Ghahramani, Despina Dobbins, Nicholas Pachuda, Ronald Montelaro, Jonathan D Steckbeck, Kenneth L Urish
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0274815 (2022)
The absence of novel antibiotics for drug-resistant and biofilm-associated infections is a global public health crisis. Antimicrobial peptides explored to address this need have encountered significant development challenges associated with size, tox
Externí odkaz:
https://doaj.org/article/59eaa2222fdc466fabfaa701ec609c4a
Autor:
Ronald C. Montelaro, Jan H. Beumer, Julie L. Eiseman, Berthony Deslouches, Jianxia Guo, Jonathan D. Steckbeck, Robert A. Parise, Evan C. Ray, Jonas Scemama
Publikováno v:
Curr Rev Clin Exp Pharmacol
Background: To address multidrug resistance, we developed engineered Cationic Antimicrobial Peptides (eCAPs). Lead eCAP WLBU2 displays potent activity against drug-resistant bacteria and effectively treats lethal bacterial infections in mice, reducin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::971296bd3979f7e32e268ce243fcacdf
https://doi.org/10.2174/1574884715666200810094201
https://doi.org/10.2174/1574884715666200810094201
Publikováno v:
Antimicrob Agents Chemother
Background: In this first in human study, PLG0206, a novel engineered cationic antimicrobial peptide was evaluated for safety, tolerability and pharmacokinetics when intravenously administered as a single dose to healthy subjects. Methods: Six cohort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a46041a9104a6e33b620f151ba0386a
https://europepmc.org/articles/PMC8765304/
https://europepmc.org/articles/PMC8765304/
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15261 (2010)
The C-terminal tail (CTT) of the HIV-1 gp41 envelope (Env) protein is increasingly recognized as an important determinant of Env structure and functional properties, including fusogenicity and antigenicity. While the CTT has been commonly referred to
Externí odkaz:
https://doaj.org/article/0bce9e6f090e4255831e611876b2136e
Autor:
Rick A Bright, Donald M Carter, Corey J Crevar, Franklin R Toapanta, Jonathan D Steckbeck, Kelly S Cole, Niranjan M Kumar, Peter Pushko, Gale Smith, Terrence M Tumpey, Ted M Ross
Publikováno v:
PLoS ONE, Vol 3, Iss 1, p e1501 (2008)
BackgroundVaccination is a cost-effective counter-measure to the threat of seasonal or pandemic outbreaks of influenza. To address the need for improved influenza vaccines and alternatives to egg-based manufacturing, we have engineered an influenza v
Externí odkaz:
https://doaj.org/article/955caa07dde04c85bc395bf08c72d287
Autor:
Ronald C. Montelaro, Mary L. Hasek, Jodi K. Craigo, Berthony Deslouches, Jonathan D. Steckbeck
Publikováno v:
Journal of Medical Microbiology. 65:554-565
We previously reported a series of de novo engineered cationic antibiotic peptides (eCAPs) consisting exclusively of arginine and tryptophan (WR) that display potent activity against diverse multidrug-resistant (MDR) bacterial strains. In this study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caf96039f107be30e7c4e5efe67e1eff
https://doi.org/10.1099/jmm.0.000258
https://doi.org/10.1099/jmm.0.000258
Autor:
Berthony Deslouches, Ronald C. Montelaro, Jonathan D. Steckbeck, Suha Abdelbaqi, Douglas S. Reed
Publikováno v:
Journal of Medical Microbiology. 65:188-194
Broad-spectrum antimicrobials are needed to effectively treat patients infected in the event of a pandemic or intentional release of a pathogen prior to confirmation of the pathogen's identity. Engineered cationic antimicrobial peptides (eCAPs) displ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c85b7f47b9ca5058ba245e8cbe848486
https://doi.org/10.1099/jmm.0.000209
https://doi.org/10.1099/jmm.0.000209
Autor:
Jodi K. Craigo, Mary L. Hasek, Jonathan D. Steckbeck, Berthony Deslouches, Ronald C. Montelaro
Publikováno v:
Journal of Antivirals & Antiretrovirals.
In recent decades, efforts have been made to rationally design antimicrobial peptides (AMPs) for use as alternative antimicrobial therapeutics. The de novo engineered cationic antimicrobial peptide (eCAP) WLBU2 is a 24-residue peptide composed of arg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66faae3c5e1a16c6a8e9531d8efd1dcc
https://doi.org/10.4172/1948-5964.1000158
https://doi.org/10.4172/1948-5964.1000158
Autor:
Ronald C. Montelaro, Jonathan D. Steckbeck, Jodi K. Craigo, Anne-Sophie Kuhlmann, Timothy J. Sturgeon
Publikováno v:
Journal of Biological Chemistry. 289:7630-7640
A previous study from our laboratory reported a preferential conservation of arginine relative to lysine in the C-terminal tail (CTT) of HIV-1 envelope (Env). Despite substantial overall sequence variation in the CTT, specific arginines are highly co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e5c7f5fa8ec2b6401e777d1b5b0a4fc
https://doi.org/10.1074/jbc.m113.529339
https://doi.org/10.1074/jbc.m113.529339