Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jonathan D. Rubin"'
Autor:
Jonathan D. Rubin, Jacob T. Stanley, Rutendo F. Sigauke, Cecilia B. Levandowski, Zachary L. Maas, Jessica Westfall, Dylan J. Taatjes, Robin D. Dowell
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Rubin et al. introduce transcription factor enrichment analysis (TFEA), a new motif enrichment method specifically aimed at maximizing the informative nature of differential RNA polymerase initiation data. It provides an easy, rigorous, and cost-effe
Externí odkaz:
https://doaj.org/article/5efe066cfacc491fafa057cc4297ed32
Autor:
Benjamin L. Allen, Kim Quach, Taylor Jones, Cecilia B. Levandowski, Christopher C. Ebmeier, Jonathan D. Rubin, Timothy Read, Robin D. Dowell, Alanna Schepartz, Dylan J. Taatjes
Publikováno v:
Cell Reports, Vol 39, Iss 1, Pp 110630- (2022)
Summary: DNA-binding transcription factors (TFs) remain challenging to target with molecular probes. Many TFs function in part through interaction with Mediator, a 26-subunit complex that controls RNA polymerase II activity genome-wide. We sought to
Externí odkaz:
https://doaj.org/article/778fb17bca8f4e708f1fcf23e5732ca5
Autor:
Rutendo F. Sigauke, Jessica T. Westfall, Zachary L. Maas, Dylan J. Taatjes, Robin D. Dowell, Jacob T. Stanley, Cecilia B. Levandowski, Jonathan D. Rubin
1AbstractDetecting differential activation of transcription factors (TFs) in response to perturbation provides insight into cellular processes. Transcription Factor Enrichment Analysis (TFEA) is a robust and reliable computational method that detects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f6d70cf9e322afec7179036698cbfb6
https://doi.org/10.1101/2020.01.25.919738
https://doi.org/10.1101/2020.01.25.919738
Autor:
Jonathan D. Rubin, Jenna K. Rimel, Charli B. Fant, Zachary L. Maas, Dylan J. Taatjes, Meagan N. Esbin, Michael T. Marr, John Moir, Cecilia B. Levandowski, Kapil Gupta, Andrew Sawyer, Olivia Luyties, Robin D. Dowell, Imre Berger
Publikováno v:
Fant, C B, Levandowski, C B, Gupta, K, Maas, Z L, Moir, J, Rubin, J D, Sawyer, A, Esbin, M N, Rimel, J K, Luyties, O, Marr, M T, Berger, I, Dowell, R D & Taatjes, D J 2020, ' TFIID Enables RNA Polymerase II Promoter-Proximal Pausing ', Molecular Cell, vol. 78, no. 4, pp. 785-793.e8 . https://doi.org/10.1016/j.molcel.2020.03.008
Mol Cell
Mol Cell
Summary RNA polymerase II (RNAPII) transcription is governed by the pre-initiation complex (PIC), which contains TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, RNAPII, and Mediator. After initiation, RNAPII enzymes pause after transcribing less than 100 b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14f69ca34ab9220900fbd1069a208f44
https://doi.org/10.2139/ssrn.3429345
https://doi.org/10.2139/ssrn.3429345
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 35:667-675
The availability of transgenic strains has made the laboratory mouse a popular model for the study of healthy and diseased state spinal cord (SC). Essential to identifying physiologic and pathologic events is an understanding of the microvascular net
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6701b76a22582f89a45f821d3c70dd71
https://doi.org/10.1038/jcbfm.2014.244
https://doi.org/10.1038/jcbfm.2014.244
Autor:
Mary A. Allen, Josephina R. Hendrix, Joseph Azofeifa, Timothy Read, Robin D. Dowell, Jonathan D. Rubin
Publikováno v:
Genome research.
Transcription factors (TFs) exert their regulatory influence through the binding of enhancers, resulting in coordination of gene expression programs. Active enhancers are often characterized by the presence of short, unstable transcripts termed enhan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b067e296a023b3cd274f90bdc0628a5
https://pubmed.ncbi.nlm.nih.gov/29449408
https://pubmed.ncbi.nlm.nih.gov/29449408
Autor:
Terezia Vcelkova, Heather Bender, Iris Steinparzer, Giulio Superti-Furga, Matthew D. Galbraith, Vitaly Sedlyarov, Lucy Sneezum, Renata Kleinova, Dylan J. Taatjes, Robin D. Dowell, Kevin Eislmayr, Zdenek Andrysik, Jonathan D. Rubin, Joaquín M. Espinosa, Fabian Amman, Florian Wascher, Cecilia B. Levandowski, Pavel Kovarik
Publikováno v:
Molecular Cell
Summary Transcriptional responses to external stimuli remain poorly understood. Using global nuclear run-on followed by sequencing (GRO-seq) and precision nuclear run-on sequencing (PRO-seq), we show that CDK8 kinase activity promotes RNA polymerase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48b29514dad966190fddc5a338df12b2
https://doi.org/10.1016/j.molcel.2019.07.034
https://doi.org/10.1016/j.molcel.2019.07.034
Autor:
Jonathan D. Rubin, Dylan J. Taatjes
Publikováno v:
Nature. 526:199-200
The finding that the Mediator protein complex contributes to messenger RNA export from the nucleus in yeast adds to a growing list of roles for the complex in regulating transcriptional processes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4def760d61c482269b88dd3f46aa8853
https://doi.org/10.1038/526199a
https://doi.org/10.1038/526199a
Autor:
Jian Q. Yu, Kathleen M. Woods, Simin Dadparvar, Lori Jardines, Jonathan D. Rubin, Patricia McNellis
Publikováno v:
The Cancer Journal. 8:495
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b471d9e048a5e9dc5adc40105350c2c6
https://doi.org/10.1097/00130404-200211000-00046
https://doi.org/10.1097/00130404-200211000-00046