Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jonathan D. Nardozzi"'
Autor:
Jason Schapansky, Saurabh Khasnavis, Mark P. DeAndrade, Jonathan D. Nardozzi, Samuel R. Falkson, Justin D. Boyd, John B. Sanderson, Tim Bartels, Heather L. Melrose, Matthew J. LaVoie
Publikováno v:
Neurobiology of Disease, Vol 111, Iss , Pp 26-35 (2018)
Missense mutations in the multi-domain kinase LRRK2 cause late onset familial Parkinson's disease. They most commonly with classic proteinopathy in the form of Lewy bodies and Lewy neurites comprised of insoluble α-synuclein, but in rare cases can a
Externí odkaz:
https://doaj.org/article/fd9888c9cbe94f60a22d9ed0b3ff97d3
Autor:
Douglas S. Jones, Jonathan D. Nardozzi, Katharine L. Sackton, Gulzar Ahmad, Esben Christensen, Lars Ringgaard, De-Kuan Chang, Ditte E. Jaehger, Jacob V. Konakondla, Martin Wiinberg, Katherine L. Stokes, Alvin Pratama, Karsten Sauer, Thomas L. Andresen
Publikováno v:
Jones, D S, Nardozzi, J D, Sackton, K L, Ahmad, G, Christensen, E, Ringgaard, L, Chang, D-K, Jaehger, D E, Konakondla, J V, Wiinberg, M, Stokes, K L, Pratama, A, Sauer, K & Andresen, T L 2022, ' Cell surface-tethered IL-12 repolarizes the tumor immune microenvironment to enhance the efficacy of adoptive T cell therapy ', Science Advances, vol. 8, no. 17, eabi8075 . https://doi.org/10.1126/sciadv.abi8075
Immune-activating cytokines such as interleukin-12 (IL-12) hold strong potential for cancer immunotherapy but have been limited by high systemic toxicities. We describe here an approach to safely harness cytokine biology for adoptive cell therapy thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f85cf01613a400cde2392bacb4cddab
https://pubmed.ncbi.nlm.nih.gov/35476449
https://pubmed.ncbi.nlm.nih.gov/35476449
Autor:
Samuel R. Falkson, Mark P. DeAndrade, Tim Bartels, Justin D. Boyd, Heather L. Melrose, Saurabh Khasnavis, Jason Schapansky, Matthew J. LaVoie, Jonathan D. Nardozzi, John B. Sanderson
Publikováno v:
Neurobiology of Disease, Vol 111, Iss, Pp 26-35 (2018)
Missense mutations in the multi-domain kinase LRRK2 cause late onset familial Parkinson's disease. They most commonly with classic proteinopathy in the form of Lewy bodies and Lewy neurites comprised of insoluble α-synuclein, but in rare cases can a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db4b8743a96831f647526800a79b2673
http://www.sciencedirect.com/science/article/pii/S0969996117302838
http://www.sciencedirect.com/science/article/pii/S0969996117302838
Publikováno v:
Journal of Biological Chemistry. 284:10129-10137
The Vaccinia virus H1 gene product, VH1, is a dual specificity phosphatase that down-regulates the cellular antiviral response by dephosphorylating STAT1. The crystal structure of VH1, determined at 1.32 A resolution, reveals a novel dimeric quaterna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9caf50e2aadd063128e72f9d8af39a31
https://doi.org/10.1074/jbc.m808362200
https://doi.org/10.1074/jbc.m808362200
Publikováno v:
Neuroscience. 302
The proteins alpha-synuclein (αSyn) and leucine rich repeat kinase 2 (LRRK2) are both key players in the pathogenesis of the neurodegenerative disorder Parkinson's disease (PD), but establishing a functional link between the two proteins has proven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8228b30aa6649afb8c81fd4b4ef8b43
https://pubmed.ncbi.nlm.nih.gov/25284317
https://pubmed.ncbi.nlm.nih.gov/25284317
Publikováno v:
Cell Death & Disease
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder, affecting 1–3% of the population over 65. Mutations in the ubiquitin E3 ligase parkin are the most common cause of autosomal recessive PD. The parkin protein posses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f38c28edc2a3003d8b8ede267fe8d0f3
https://pubmed.ncbi.nlm.nih.gov/24991765
https://pubmed.ncbi.nlm.nih.gov/24991765
Publikováno v:
The FASEB Journal. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f30dcab98c95db903b1729bfcc4655e
https://doi.org/10.1096/fasebj.26.1_supplement.lb84
https://doi.org/10.1096/fasebj.26.1_supplement.lb84
The human genome encodes six isoforms of importin α that show greater than 60% sequence similarity and remarkable substrate specificity. The isoform importin α5 can bind phosphorylated cargos such as STAT1 and Epstein-Barr Virus Nuclear Antigen 1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bc1b430983487194765115651a32208
https://europepmc.org/articles/PMC3265882/
https://europepmc.org/articles/PMC3265882/
Autor:
Stephan Wilkens, Elizabeth Hoffman, Jonathan D. Nardozzi, MacMillan Mbantenkhu, Xin Jie Chen, Xiaowen Wang, Michael S. Cosgrove, Anamika Patel
Homologous recombination is a conserved molecular process that has primarily evolved for the repair of double-stranded DNA breaks and stalled replication forks. However, the recombination machinery in mitochondria is poorly understood. Here, we show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f26271c31b350b56456c8077eeb0e663
https://europepmc.org/articles/PMC3234957/
https://europepmc.org/articles/PMC3234957/
Publikováno v:
Cell Communication and Signaling, Vol 8, Iss 1, p 32 (2010)
Cell Communication and Signaling : CCS
Cell Communication and Signaling : CCS
Phosphorylation is the most common and pleiotropic modification in biology, which plays a vital role in regulating and finely tuning a multitude of biological pathways. Transport across the nuclear envelope is also an essential cellular function and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83f3f736f7321df12fd31183f84b49a0
https://doi.org/10.1186/1478-811x-8-32
https://doi.org/10.1186/1478-811x-8-32