Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jonathan D. Leslie"'
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e68021 (2013)
Accurate regulation of Notch signalling is central for developmental processes in a variety of tissues, but its function in pectoral fin development in zebrafish is still unknown.Here we show that core elements necessary for a functional Notch pathwa
Externí odkaz:
https://doaj.org/article/27d58beb52954655bac87a3ff9638601
Autor:
Maria Kotini, Elias H. Barriga, Marc Gentzel, Alexandra Schambony, Roberto Mayor, Jonathan D. Leslie
Connexins are the primary components of gap junctions, providing direct links between cells in many physiological processes, including cell migration and cancer metastasis. Exactly how cell migration is controlled by gap junctions remains a mystery.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25590c9f4b2515f77ef8b23d110bb107
https://doi.org/10.1101/114371
https://doi.org/10.1101/114371
Autor:
Jonathan D. Leslie, Maria Kotini, Roberto Mayor, Verena Rauschenberger, Alexandra Schambony, Marc Gentzel, Elias H. Barriga
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
Nature Communications
Nature Communications
Connexins are the primary components of gap junctions, providing direct links between cells under many physiological processes. Here, we demonstrate that in addition to this canonical role, Connexins act as transcriptional regulators. We show that Co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7414557ed288164983cf387d3780839b
https://doaj.org/article/e299ae506e194567bff4ab92006cda0c
https://doaj.org/article/e299ae506e194567bff4ab92006cda0c
Autor:
Li-Kun Phng, Sujata Rao, Richard A. Lang, Ivan B. Lobov, Michael Potente, Jennifer K. Ondr, Daniel Nyqvist, Jonathan D. Leslie, Gavin Thurston, Jane Babbage, Holger Gerhardt
Publikováno v:
Dev Cell
SummaryWhen and where to make or break new blood vessel connections is the key to understanding guided vascular patterning. VEGF-A stimulation and Dll4/Notch signaling cooperatively control the number of new connections by regulating endothelial tip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13a7c534a9f0cbdc28e2ec28b2307418
https://doi.org/10.1016/j.devcel.2008.12.009
https://doi.org/10.1016/j.devcel.2008.12.009
Autor:
James F. Otto, Karen S. Wilcox, Mark Leppert, E. Jill Dahle, Jonathan D. Leslie, Chris Pappas, Jeffrey L. Noebels, H. Steve White, Nanda A. Singh, Alex Vilaythong
Publikováno v:
The Journal of Physiology. 586:3405-3423
The childhood epilepsy syndrome of benign familial neonatal convulsions (BFNC) exhibits the remarkable feature of clinical remission within a few weeks of onset and a favourable prognosis, sparing cognitive abilities despite persistent expression of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70b23b59e42321bd614404d7c550e2fb
https://doi.org/10.1113/jphysiol.2008.154971
https://doi.org/10.1113/jphysiol.2008.154971
Publikováno v:
Journal of Biological Chemistry. 272:29790-29794
The human autosomal recessive disorder Chediak-Higashi syndrome and its murine homologue beige are associated with the formation of giant lysosomes that cluster near the perinuclear region of cells. We prepared a polyclonal antiserum against a glutat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30a3a6555c34374cca06de91f520273e
https://doi.org/10.1074/jbc.272.47.29790
https://doi.org/10.1074/jbc.272.47.29790
Publikováno v:
The Journal of Cell Biology
Lysosomes are dynamic structures capable of fusing with endosomes as well as other lysosomes. We examined the biochemical requirements for homotypic lysosome fusion in vitro using lysosomes obtained from rabbit alveolar macrophages or the cultured ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72216ca457e5ba6c4b41b86ed43fa741
http://europepmc.org/articles/PMC2141702
http://europepmc.org/articles/PMC2141702
Autor:
Nanda A, Singh, James F, Otto, E Jill, Dahle, Chris, Pappas, Jonathan D, Leslie, Alex, Vilaythong, Jeffrey L, Noebels, H Steve, White, Karen S, Wilcox, Mark F, Leppert
Publikováno v:
The Journal of physiology. 586(14)
The childhood epilepsy syndrome of benign familial neonatal convulsions (BFNC) exhibits the remarkable feature of clinical remission within a few weeks of onset and a favourable prognosis, sparing cognitive abilities despite persistent expression of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a7652cd2e5d3ec894318b6498cf55c84
https://pubmed.ncbi.nlm.nih.gov/18483067
https://pubmed.ncbi.nlm.nih.gov/18483067
Autor:
Linda Ariza-McNaughton, Adam L. Bermange, Jonathan D. Leslie, Ryan Mcadow, Stephen L. Johnson, Julian Lewis
Publikováno v:
Development (Cambridge, England). 134(5)
Notch signalling by the ligand Delta-like 4 (Dll4) is essential for normal vascular remodelling, yet the precise way in which the pathway influences the behaviour of endothelial cells remains a mystery. Using the embryonic zebrafish, we show that, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e13258512c95b8f896f7e1fc21ff7354
https://pubmed.ncbi.nlm.nih.gov/17251261
https://pubmed.ncbi.nlm.nih.gov/17251261
Publikováno v:
Development (Cambridge, England). 131(22)
Delta proteins activate Notch through a binding reaction that depends on their extracellular domains; but the intracellular (C-terminal) domains of the Deltas also have significant functions. All classes of vertebrates possess a subset of Delta prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb3b979496e2a4f3a4b2aec0f557c4e6
https://pubmed.ncbi.nlm.nih.gov/15509766
https://pubmed.ncbi.nlm.nih.gov/15509766