Výsledky vyhledávání - "Jonathan D. J. Wrigley"

Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism

Autor: Dirk, Beher, Earl E, Clarke, Jonathan D J, Wrigley, Agnes C L, Martin, Alan, Nadin, Ian, Churcher, Mark S, Shearman

Publikováno v: The Journal of biological chemistry. 279(42)

Gamma-secretase is a multi-component enzyme complex that performs an intramembranous cleavage, releasing amyloid-beta (Abeta) peptides from processing intermediates of the beta-amyloid precursor protein. Because Abeta peptides are thought to be causa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ae96dbfbacccbb8f3700e149557e0aec
https://pubmed.ncbi.nlm.nih.gov/15304503

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Design and synthesis of highly potent benzodiazepine gamma-secretase inhibitors: preparation of (2S,3R)-3-(3,4-difluorophenyl)-2-(4-fluorophenyl)-4- hydroxy-N-((3S)-1-methyl-2-oxo-5- phenyl-2,3-dihydro-1H-benzo[e][1,4]-diazepin-3-yl)butyramide by use of an asymmetric Ireland-Claisen rearrangement

Autor: Ian, Churcher, Susie, Williams, Sonia, Kerrad, Timothy, Harrison, José L, Castro, Mark S, Shearman, Huw D, Lewis, Earl E, Clarke, Jonathan D J, Wrigley, Dirk, Beher, Yui S, Tang, Wensheng, Liu

Publikováno v: Journal of medicinal chemistry. 46(12)

Novel benzodiazepine-containing gamma-secretase inhibitors for potential use in Alzheimer's disease have been designed that incorporate a substituted hydrocinnamide C-3 side chain. A syn combination of alpha-alkyl or aryl and beta-hydroxy or hydroxym

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::12eccae3bbbbf4c66a91024b90e2c14e
https://pubmed.ncbi.nlm.nih.gov/12773031

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Generation of C-terminally truncated amyloid-beta peptides is dependent on gamma-secretase activity

Autor: Dirk, Beher, Jonathan D J, Wrigley, Andrew P, Owens, Mark S, Shearman

Publikováno v: Journal of neurochemistry. 82(3)

Aberrant production of amyloid-beta peptides by processing of the beta-amyloid precursor protein leads to the formation of characteristic extracellular protein deposits which are thought to be the cause of Alzheimer's disease. Therefore, inhibiting t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6a82d28a8e9bf8180acdd9d89a102502
https://pubmed.ncbi.nlm.nih.gov/12153480

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Akademický článek

Novel Orally Bioavailable γ-Secretase Inhibitors with Excellent in Vivo Activity.

Autor: Linda E. Keown, Ian Collins, Laura C. Cooper, Timothy Harrison, Andrew Madin, Jayesh Mistry, Michael Reilly, Mohamed Shaimi, Christopher J. Welch, Earl E. Clarke, Huw D. Lewis, Jonathan D. J. Wrigley, Jonathan D. Best, Fraser Murray, Mark S. Shearman

Publikováno v: Journal of Medicinal Chemistry; Jun2009, Vol. 52 Issue 11, p3441-3444, 4p

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