Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Jonathan D. Graves"'
Publikováno v:
Clinical Cancer Research. 16:1701-1708
Apoptosis is integral to normal, physiologic processes that regulate cell number and results in the removal of unnecessary or damaged cells. Apoptosis is frequently dysregulated in human cancers, and recent advancements in our understanding of the re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bccd3f099833345f16362659807411e6
https://doi.org/10.1158/1078-0432.ccr-09-1692
https://doi.org/10.1158/1078-0432.ccr-09-1692
Autor:
Rafael Pulido, Michael P. Myers, Joe Rodriguez, Jonathan D. Graves, Nicholas K. Tonks, Josema Torres, Miguel Valiente
Publikováno v:
Journal of Biological Chemistry. 278:30652-30660
PTEN phosphatase is one of the most commonly targeted tumor suppressors in human cancers and a key regulator of cell growth and apoptosis. We have found that PTEN is cleaved by caspase-3 at several target sites, located in unstructured regions within
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3fadc8416e4b788c5f1f4db1a7a11e50
https://doi.org/10.1074/jbc.m212610200
https://doi.org/10.1074/jbc.m212610200
Publikováno v:
Proceedings of the National Academy of Sciences. 98:10148-10153
MST1, mammalian STE20-like kinase 1, is a serine/threonine kinase that is cleaved and activated by caspases during apoptosis. MST1 is capable of inducing apoptotic morphological changes such as chromatin condensation upon overexpression. In this stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::718f881979bbf71bd46ef4d19c42ddf6
https://doi.org/10.1073/pnas.181161698
https://doi.org/10.1073/pnas.181161698
CD95/Fas induces cleavage of the GrpL/Gads adaptor and desensitization of antigen receptor signaling
Publikováno v:
Proceedings of the National Academy of Sciences. 98:6789-6793
The balance between cell survival and cell death is critical for normal lymphoid development. This balance is maintained by signals through lymphocyte antigen receptors and death receptors such as CD95/Fas. In some cells, ligating the B cell antigen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e497f9f1202fd2c376a980cb12a88f21
https://doi.org/10.1073/pnas.111158598
https://doi.org/10.1073/pnas.111158598
Publikováno v:
Genes to Cells. 6:519-530
Background MST1 is an upstream kinase of the JNK and p38 MAPK pathways whose expression induces apoptotic morphological changes such as nuclear condensation. During apoptosis, caspase cleavage of MST1 removes a C-terminal regulatory domain, increasin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f8dc4cee031febfc56f7148bd8257fe
https://doi.org/10.1046/j.1365-2443.2001.00439.x
https://doi.org/10.1046/j.1365-2443.2001.00439.x
Publikováno v:
Journal of Biological Chemistry. 276:14909-14915
The serine/threonine kinase Mst1, a mammalian homolog of the budding yeast Ste20 kinase, is cleaved by caspase-mediated proteolysis in response to apoptotic stimuli such as ligation of CD95/Fas or treatment with staurosporine. Furthermore, overexpres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58dbba5e4d4a5b801fc149fdc18d29b5
https://doi.org/10.1074/jbc.m010905200
https://doi.org/10.1074/jbc.m010905200
Autor:
Jonathan D. Graves, Edwin G. Krebs
Publikováno v:
Advances in Enzyme Regulation. 40:441-470
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95bfb85ae5212c297e34dd3e1f46e467
https://doi.org/10.1016/s0065-2571(99)00030-8
https://doi.org/10.1016/s0065-2571(99)00030-8
Publikováno v:
The Journal of Immunology. 161:168-174
To define how the signaling pathways that mediate the B cell receptor (BCR) death pathway differ from those responsible for CD95/Fas-mediated death, we compared the BCR and Fas death pathways in two human B cell lines, B104 and BJAB. Both BCR- and Fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7a562986fd34935e4f7fbcfadcdcd57
https://doi.org/10.4049/jimmunol.161.1.168
https://doi.org/10.4049/jimmunol.161.1.168
Autor:
Diane M. Ambrose, David K. Han, Edwin G. Krebs, Kevin E. Draves, Yukiko Gotoh, Jonathan Chernoff, Michael E. Wright, Edward A. Clark, Jonathan D. Graves
Publikováno v:
The EMBO Journal. 17:2224-2234
Mst1 is a ubiquitously expressed serine-threonine kinase, homologous to the budding yeast Ste20, whose physiological regulation and cellular function are unknown. In this paper we show that Mst1 is specifically cleaved by a caspase 3-like activity du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f71851de3e489d70dec3bc0803b323
https://doi.org/10.1093/emboj/17.8.2224
https://doi.org/10.1093/emboj/17.8.2224
Autor:
Mohd Fauzi Ramlan, Jonathan D. Graves
Publikováno v:
Journal of Experimental Botany. 47:71-78
Sensitivity to photoinhibition was assessed in sorghum infected with the angiosperm root parasite Striga hermonthica and in uninfected sorghum plants, at four times during the development of the host-parasite association. Photoinhibition was induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a861b3003a469f2f988c55398ca2c62
https://doi.org/10.1093/jxb/47.1.71
https://doi.org/10.1093/jxb/47.1.71