Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Jonathan D. Gilthorpe"'
Autor:
Sandhya Malla, Kanchan Kumari, Carlos A. García-Prieto, Jonatan Caroli, Anna Nordin, Trinh T. T. Phan, Devi Prasad Bhattarai, Carlos Martinez-Gamero, Eshagh Dorafshan, Stephanie Stransky, Damiana Álvarez-Errico, Paulina Avovome Saiki, Weiyi Lai, Cong Lyu, Ludvig Lizana, Jonathan D. Gilthorpe, Hailin Wang, Simone Sidoli, Andre Mateus, Dung-Fang Lee, Claudio Cantù, Manel Esteller, Andrea Mattevi, Angel-Carlos Roman, Francesca Aguilo
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-24 (2024)
Abstract Lysine-specific histone demethylase 1 (LSD1), which demethylates mono- or di- methylated histone H3 on lysine 4 (H3K4me1/2), is essential for early embryogenesis and development. Here we show that LSD1 is dispensable for mouse embryonic stem
Externí odkaz:
https://doaj.org/article/2d6f847ecfc84532b688deb0fc0250d8
Autor:
Longjun Pu, Jing Wang, Qiongxuan Lu, Lars Nilsson, Alison Philbrook, Anjali Pandey, Lina Zhao, Robin van Schendel, Alan Koh, Tanara V. Peres, Weheliye H. Hashi, Si Lhyam Myint, Chloe Williams, Jonathan D. Gilthorpe, Sun Nyunt Wai, Andre Brown, Marcel Tijsterman, Piali Sengupta, Johan Henriksson, Changchun Chen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract G protein-coupled receptors (GPCRs) mediate responses to various extracellular and intracellular cues. However, the large number of GPCR genes and their substantial functional redundancy make it challenging to systematically dissect GPCR fun
Externí odkaz:
https://doaj.org/article/24e1b9e01e0d43e0a19e2412288d53fd
Publikováno v:
Medicina, Vol 60, Iss 8, p 1343 (2024)
Background and Objective: An unexpected batch-dependent safety signal for the BNT162b2 mRNA COVID-19 vaccine was recently identified in a nationwide study from Denmark, but the generalizability of this finding is unknown. Therefore, we compared batch
Externí odkaz:
https://doaj.org/article/8271b09cbe1049a8b3f1cfca8b573833
Autor:
Ioannis S. Pateras, Chloe Williams, Despoina D. Gianniou, Aggelos T. Margetis, Margaritis Avgeris, Pantelis Rousakis, Aigli-Ioanna Legaki, Peter Mirtschink, Wei Zhang, Konstantina Panoutsopoulou, Anastasios D. Delis, Stamatis N. Pagakis, Wei Tang, Stefan Ambs, Ulrika Warpman Berglund, Thomas Helleday, Anastasia Varvarigou, Antonios Chatzigeorgiou, Anders Nordström, Ourania E. Tsitsilonis, Ioannis P. Trougakos, Jonathan D. Gilthorpe, Teresa Frisan
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-22 (2023)
Abstract Background Chemotherapy (CT) is central to the treatment of triple negative breast cancer (TNBC), but drug toxicity and resistance place strong restrictions on treatment regimes. Fasting sensitizes cancer cells to a range of chemotherapeutic
Externí odkaz:
https://doaj.org/article/664873a7a747491ba70f6612076606eb
Autor:
Shamasree Ghosh, Shanmugam Tamilselvi, Chloe Williams, Sanduni W. Jayaweera, Igor A. Iashchishyn, Darius Šulskis, Jonathan D. Gilthorpe, Anders Olofsson, Vytautas Smirnovas, Željko M. Svedružić, Ludmilla A. Morozova-Roche
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 4, p 2114 (2024)
Increasing evidence suggests that the calcium-binding and proinflammatory protein S100A9 is an important player in neuroinflammation-mediated Alzheimer’s disease (AD). The amyloid co-aggregation of S100A9 with amyloid-β (Aβ) is an important hallm
Externí odkaz:
https://doaj.org/article/12b73d3426dc44d683ac49c0ae749dc4
Autor:
Manuela Lehmann, Matthew Marklund, Anna-Lena Bolender, Elaheh E. Bidhendi, Per Zetterström, Peter M. Andersen, Thomas Brännström, Stefan L. Marklund, Jonathan D. Gilthorpe, Ulrika Nordström
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-18 (2020)
Abstract Increasing evidence suggests that propagation of the motor neuron disease amyotrophic lateral sclerosis (ALS) involves the pathogenic aggregation of disease-associated proteins that spread in a prion-like manner. We have identified two aggre
Externí odkaz:
https://doaj.org/article/36abdf0346ab411681ed231180153dc2
Autor:
René Günther, Arun Pal, Chloe Williams, Vitaly L. Zimyanin, Maria Liehr, Cläre von Neubeck, Mechthild Krause, Mrudula G. Parab, Susanne Petri, Norman Kalmbach, Stefan L. Marklund, Jared Sterneckert, Peter Munch Andersen, Florian Wegner, Jonathan D. Gilthorpe, Andreas Hermann
Publikováno v:
Cells, Vol 11, Iss 7, p 1246 (2022)
Little is known about the early pathogenic events by which mutant superoxide dismutase 1 (SOD1) causes amyotrophic lateral sclerosis (ALS). This lack of mechanistic understanding is a major barrier to the development and evaluation of efficient thera
Externí odkaz:
https://doaj.org/article/a384eecc4dc6440ea19379b4d2551e7d
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-11 (2018)
Abstract Background Flaviviruses are a group of diverse and emerging arboviruses and an immense global health problem. A number of flaviviruses are neurotropic, causing severe encephalitis and even death. Type I interferons (IFNs) are the first line
Externí odkaz:
https://doaj.org/article/a8065e5d4eb34a4f8f00099a3d9a8d07
Autor:
Clemens Falker‐Gieske, Nora‐Fabienne Paul, Maria Spourita, Jonathan D. Gilthorpe, Karolin Gustmann, Jens Tetens
Chicken amyloid arthropathy is a debilitating disease with a major impact on animal welfare. Since the disease is triggered by bacterial infection, preventative treatment also contributes to the widespread overuse of antibiotics. Bacterial infection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::392204168920ee1d9166555c153409bd
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-202058
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-202058
Autor:
Axel Leppert, Gefei Chen, Danai Lianoudaki, Chloe Williams, Xueying Zhong, Jonathan D. Gilthorpe, Michael Landreh, Jan Johansson
Publikováno v:
Protein science : a publication of the Protein Society. 31(8)
Molecular chaperones are essential to maintain proteostasis. While the functions of intracellular molecular chaperones that oversee protein synthesis, folding and aggregation, are established, those specialized to work in the extracellular environmen