Zobrazeno 1 - 10
of 157
pro vyhledávání: '"Jonathan D. Edgeworth"'
Autor:
Themoula Charalampous, Adela Alcolea-Medina, Luke B. Snell, Tom G. S. Williams, Rahul Batra, Christopher Alder, Andrea Telatin, Luigi Camporota, Christopher I. S. Meadows, Duncan Wyncoll, Nicholas A. Barrett, Carolyn J. Hemsley, Lisa Bryan, William Newsholme, Sara E. Boyd, Anna Green, Ula Mahadeva, Amita Patel, Penelope R. Cliff, Andrew J. Page, Justin O’Grady, Jonathan D. Edgeworth
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-16 (2021)
Abstract Background Clinical metagenomics (CMg) has the potential to be translated from a research tool into routine service to improve antimicrobial treatment and infection control decisions. The SARS-CoV-2 pandemic provides added impetus to realise
Externí odkaz:
https://doaj.org/article/3c7a335029394a13877c2e9c82267e9d
Autor:
Clemens Gutmann, Kaloyan Takov, Sean A. Burnap, Bhawana Singh, Hashim Ali, Konstantinos Theofilatos, Ella Reed, Maria Hasman, Adam Nabeebaccus, Matthew Fish, Mark JW. McPhail, Kevin O’Gallagher, Lukas E. Schmidt, Christian Cassel, Marieke Rienks, Xiaoke Yin, Georg Auzinger, Salvatore Napoli, Salma F. Mujib, Francesca Trovato, Barnaby Sanderson, Blair Merrick, Umar Niazi, Mansoor Saqi, Konstantina Dimitrakopoulou, Rafael Fernández-Leiro, Silke Braun, Romy Kronstein-Wiedemann, Katie J. Doores, Jonathan D. Edgeworth, Ajay M. Shah, Stefan R. Bornstein, Torsten Tonn, Adrian C. Hayday, Mauro Giacca, Manu Shankar-Hari, Manuel Mayr
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Here the authors use RT-qPCR and mass spectrometry to analyze longitudinal blood samples from intensive care unit (ICU) COVID-19 patients and controls. They find that viral RNA and pentraxin-3 predict 28-day ICU mortality and that galectin-3-binding
Externí odkaz:
https://doaj.org/article/4473e05193134fe3b894751bffb9a062
Autor:
Thomas Lechmere, Luke B. Snell, Carl Graham, Jeffrey Seow, Zayed A. Shalim, Themoula Charalampous, Adela Alcolea-Medina, Rahul Batra, Gaia Nebbia, Jonathan D. Edgeworth, Michael H. Malim, Katie J. Doores
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT Numerous studies have shown that a prior SARS-CoV-2 infection can greatly enhance the antibody response to COVID-19 vaccination, with this so called “hybrid immunity” leading to greater neutralization breadth against SARS-CoV-2 variants
Externí odkaz:
https://doaj.org/article/532af9eb26d2434498e1ed5b78f8f9bd
Autor:
Olga Tosas Auguet, Rene Niehus, Hyun Soon Gweon, James A. Berkley, Joseph Waichungo, Tsi Njim, Jonathan D. Edgeworth, Rahul Batra, Kevin Chau, Jeremy Swann, Sarah A. Walker, Tim E.A. Peto, Derrick W. Crook, Sarah Lamble, Paul Turner, Ben S. Cooper, Nicole Stoesser
Publikováno v:
EClinicalMedicine, Vol 36, Iss , Pp 100910- (2021)
Background: Antimicrobial resistance (AMR) in Enterobacterales is a global health threat. Capacity for individual-level surveillance remains limited in many countries, whilst population-level surveillance approaches could inform empiric antibiotic tr
Externí odkaz:
https://doaj.org/article/36d230a199a54018a8eda0d33c7ef6bb
Autor:
Tal Noy-Porat, Adva Mechaly, Yinon Levy, Efi Makdasi, Ron Alcalay, David Gur, Moshe Aftalion, Reut Falach, Shani Leviatan Ben-Arye, Shirley Lazar, Ayelet Zauberman, Eyal Epstein, Theodor Chitlaru, Shay Weiss, Hagit Achdout, Jonathan D. Edgeworth, Raghavendra Kikkeri, Hai Yu, Xi Chen, Shmuel Yitzhaki, Shmuel C. Shapira, Vered Padler-Karavani, Ohad Mazor, Ronit Rosenfeld
Publikováno v:
iScience, Vol 24, Iss 5, Pp 102479- (2021)
Summary: Neutralizing antibodies represent a valuable therapeutic approach to countermeasure the current COVID-19 pandemic. Emergence of SARS-CoV-2 variants emphasizes the notion that antibody treatments need to rely on highly neutralizing monoclonal
Externí odkaz:
https://doaj.org/article/5be2c18d8ba44814aa7c3af9cabd005d
Autor:
Jonathan D. Edgeworth, Rahul Batra, Gaia Nebbia, Karen Bisnauthsing, Eithne MacMahon, Malur Sudhanva, Sam Douthwaite, Simon Goldenberg, Geraldine O’Hara, Manu Shankar-Hari, Katie J. Doores, Rocio Martinez-Nunez, Carolyn Hemsley, Nicholas M. Price, Jill Lockett, Robert I. Lechler, Stuart J. D. Neil, Michael H. Malim, Carolyn B. Coyne
Publikováno v:
PLoS Pathogens, Vol 16, Iss 9 (2020)
Externí odkaz:
https://doaj.org/article/267de135fcda4e588444060c1f323993
Autor:
Sofia Santos Costa, Benjamin Sobkowiak, Ricardo Parreira, Jonathan D. Edgeworth, Miguel Viveiros, Taane G. Clark, Isabel Couto
Publikováno v:
Frontiers in Genetics, Vol 9 (2019)
NorA is the best studied efflux system of Staphylococcus aureus and therefore frequently used as a model for investigating efflux-mediated resistance in this pathogen. NorA activity is associated with resistance to fluoroquinolones, several antisepti
Externí odkaz:
https://doaj.org/article/d3013cd1bdbb4d3e96b70b6a0b9c372c
Autor:
Lara Payne, Adela Alcolea-Medina, Luke B Snell, Christopher Alder, Themoula Charalampous, Jake D Turnbull, Jonathan D Edgeworth, Rahul Batra, John L Klein, Anna L Goodman
Publikováno v:
Clinical Infection in Practice, Vol 21, Iss , Pp 100332- (2024)
Background: We describe a case of a 55-year-old shepherd with history of mycotic aneurysm presenting with a chronic aortic endovascular graft infection caused by Nocardia nova and a newly identified Variovorax sp which we named ‘Variovorax durovern
Externí odkaz:
https://doaj.org/article/6943fbd054e8406ca975d92cbf72017d
Autor:
Wenjuan Wang, Luke B Snell, Davide Ferrari, Anna L Goodman, Nicholas M Price, Charles D Wolfe, Vasa Curcin, Jonathan D Edgeworth, Yanzhong Wang
Publikováno v:
BMC Infectious Diseases, Vol 22, Iss 1, Pp 1-7 (2022)
Abstract Introduction Randomised controlled trials have shown that steroids reduce the risk of dying in patients with severe Coronavirus disease 2019 (COVID-19), whilst many real-world studies have failed to replicate this result. We aim to investiga
Externí odkaz:
https://doaj.org/article/8dda7d566c344eda87fd1ba8ba4e2aa5
Autor:
Jonathan D. Edgeworth
Publikováno v:
Current Opinion in Infectious Diseases. 36:115-123