Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Jonathan D. Bloom"'
Autor:
Brian J. Petersen, Gary M. Rothenberg, Priti J. Lakhani, Min Zhou, David R. Linders, Jonathan D. Bloom, Katherine A. Wood, David G. Armstrong
Publikováno v:
Journal of Foot and Ankle Research, Vol 13, Iss 1, Pp 1-6 (2020)
Abstract Background The “cancer analogy” is powerful for communicating risk to and organizing care for patients with diabetic foot syndrome. One potentially underappreciated similarity between cancer and foot ulcers is that both can recur at anat
Externí odkaz:
https://doaj.org/article/a5c4d5c760264fc1ac9eb2ad45b77bfa
Autor:
Michael A. Horberg, Brian J. Petersen, Mark L Miller, Daniel J Short, Jonathan D. Bloom, Adam L. Isaac, Eleanor A Wilson, Timothy D Swartz, David R. Linders, Haihong Hu, Nicole J Neff, Jessica L Locke, Jamie L Chaffo, Simon J Salgado, Eric Watson
Publikováno v:
BMJ Open Diabetes Research & Care, Vol 8, Iss 1 (2020)
BMJ Open Diabetes Research & Care
BMJ Open Diabetes Research & Care
IntroductionWe assessed the impact of a diabetic foot ulcer prevention program incorporating once-daily foot temperature monitoring on hospitalizations, emergency department and outpatient visits, and rates of diabetic foot ulcer recurrence and lower
Autor:
Brian J. Petersen, Walter T. Linde-Zwirble, Tze-Woei Tan, Gary M. Rothenberg, Simon J. Salgado, Jonathan D. Bloom, David G. Armstrong
Publikováno v:
Diabetes Res Clin Pract
AIMS: Our primary objective was to determine whether all-cause rates of mortality and resource utilization were higher during periods of diabetic foot ulceration. In support of this objective, a secondary objective was to develop and validate an epis
Feasibility and Efficacy of a Smart Mat Technology to Predict Development of Diabetic Plantar Ulcers
Autor:
Ian L. Gordon, Bijan Najafi, Alexander M. Reyzelman, Brian J. Petersen, Aksone Nouvong, Gary M. Rothenberg, David R. Linders, Jonathan D. Bloom, Shawn Cazzell, Ryan H Fitzgerald, Robert G. Frykberg
Publikováno v:
Diabetes Care. 40:973-980
OBJECTIVE We conducted a multicenter evaluation of a novel remote foot-temperature monitoring system to characterize its accuracy for predicting impending diabetic foot ulcers (DFU) in a cohort of patients with diabetes with previously healed DFU. RE
Publikováno v:
Diabetes. 68
The aim of this study was to derive and validate a model to identify peripheral sensory neuropathy using remote temperature monitoring (RTM). We used data from a recent longitudinal study of a once-daily in-home RTM mat. Neurological status was asses
Autor:
Brian J. Petersen, Gary M. Rothenberg, Aksone Nouvong, Robert Frykberg, Bijan Najafi, Jonathan D. Bloom, Ian L. Gordon
Publikováno v:
Diabetes. 67
Diabetic foot ulcers (DFU) result in significant morbidity, mortality, and healthcare costs. Fortunately, recent data suggest as many as 75% of DFU and 60% of lower extremity amputations (LEA) may be preventable. Clinical practice guidelines recommen
Autor:
David R. Linders, Gary M. Rothenberg, David G. Armstrong, Lawrence A. Lavery, Jonathan D. Bloom, Brian J. Petersen
Publikováno v:
BMJ Open Diabetes Research & Care
ObjectiveDaily remote foot temperature monitoring is an evidence-based preventive practice for patients at risk for diabetic foot complications. Unfortunately, the conventional approach requires comparison of temperatures between contralaterally matc
Autor:
Zhong Li, Judy Lucas, Jonathan D. Bloom, Russell Dushin, Hao Liu, Mercy Otteng, Mark Johnson, Thomas Nittoli, Jeremy I. Levin, Andrea Olland, Jennifer M. Golas, Christoph W. Zapf, Erik Vogan, Antonia A. Nikitenko, Frank Boschelli
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:4602-4607
An extension of our previously reported series of macrocyclic ortho-aminobenzamide Hsp90 inhibitors is reported. Addition of a second methyl group to the tether provided analogs that show increased potency in binding as well as cell-proliferation ass
Autor:
Judy Lucas, Russell Dushin, Christoph W. Zapf, Jamie L. McBean, Hao Liu, Jennifer M. Golas, Frank Boschelli, Erik Vogan, Jeremy I. Levin, Jonathan D. Bloom
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:3627-3631
A novel series of macrocyclic ortho-aminobenzamide Hsp90 inhibitors is reported. In continuation of our research, heterocycle-containing tethers were explored with the intent to further improve potency and minimize hERG liabilities. This effort culmi
Autor:
Charles Ingalls, Yongbo Hu, Jeremy I. Levin, Jennifer M. Golas, Clark Eid, Jamie L. McBean, Russell Dushin, Hao Liu, Christoph W. Zapf, Erik Vogan, John P. Sonye, Jonathan D. Bloom, Thomas Nittoli, Alan G. Sutherland, Frank Boschelli
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:2278-2282
A novel series of macrocyclic ortho-aminobenzamide Hsp90 inhibitors is reported. A basic nitrogen within the tether linking the aniline nitrogen atom to a tetrahydroindolone moiety allowed access to compounds with good physical properties. Important