Výsledky vyhledávání - "Jonathan D Windster"

Akademický článek

Size matters: Large copy number losses in Hirschsprung disease patients reveal genes involved in enteric nervous system development.

Publikováno v: PLoS Genetics, Vol 17, Iss 8, p e1009698 (2021)

Hirschsprung disease (HSCR) is a complex genetic disease characterized by absence of ganglia in the intestine. HSCR etiology can be explained by a unique combination of genetic alterations: rare coding variants, predisposing haplotypes and Copy Numbe

Externí odkaz: https://doaj.org/article/1c07ad4d76c24f9488439c5f30f264c2

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Akademický článek

Unbiased characterization of the larval zebrafish enteric nervous system at a single cell transcriptomic level

Autor: Laura E. Kuil, Naomi J.M. Kakiailatu, Jonathan D. Windster, Eric Bindels, Joke T.M. Zink, Gaby van der Zee, Robert M.W. Hofstra, Iain T. Shepherd, Veerle Melotte, Maria M. Alves

Publikováno v: iScience, Vol 26, Iss 7, Pp 107070- (2023)

Summary: The enteric nervous system (ENS) regulates many gastrointestinal functions including peristalsis, immune regulation and uptake of nutrients. Defects in the ENS can lead to severe enteric neuropathies such as Hirschsprung disease (HSCR). Zebr

Externí odkaz: https://doaj.org/article/b7ec781be7a740e7809fef44bcc8fbf0

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Akademický článek

TFAP2B Haploinsufficiency Impacts Gastrointestinal Function and Leads to Pediatric Intestinal Pseudo-obstruction

Autor: Almira Zada, Laura E. Kuil, Bianca M. de Graaf, Naomi Kakiailatu, Jonathan D. Windster, Alice S. Brooks, Marjon van Slegtenhorst, Barbara de Koning, René M. H. Wijnen, Veerle Melotte, Robert M. W. Hofstra, Erwin Brosens, Maria M. Alves

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

Background: Pediatric Intestinal Pseudo-obstruction (PIPO) is a congenital enteric disorder characterized by severe gastrointestinal (GI) dysmotility, without mechanical obstruction. Although several genes have been described to cause this disease, m

Externí odkaz: https://doaj.org/article/88f91001bc774e99be4b2759acc6def2

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A combinatorial panel for flow cytometry-based isolation of enteric nervous system cells from human intestine

Autor: Jonathan D Windster, Andrea Sacchetti, Gerben J Schaaf, Eric MJ Bindels, Robert MW Hofstra, Rene MH Wijnen, Cornelius EJ Sloots, Maria M Alves

Publikováno v: EMBO Reports, 24(4):e55789. Wiley-Blackwell

Efficient isolation of neurons and glia from the human enteric nervous system (ENS) is challenging because of their rare and fragile nature. Here, we describe a staining panel to enrich ENS cells from the human intestine by fluorescence-activated cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::639ad5d555d6861cf9406fbecb5edfd2
https://doi.org/10.15252/embr.202255789

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Does a Dose Calculator as an Add-On to a Web-Based Paediatric Formulary Reduce Calculation Errors in Paediatric Dosing? A Non-Randomized Controlled Study

Autor: Tjitske M van der Zanden, Matthijs de Hoog, Saskia N. de Wildt, Jonathan D. Windster, I. Heleen van der Sijs, Joost van Rosmalen

Publikováno v: Paediatric Drugs, 22, 2, pp. 229-239
Paediatric Drugs
Paediatric Drugs, 22, 229-239. Adis
Paediatric Drugs, 22, 229-239

Objectives The structured digital dosing guidelines of the web-based Dutch Paediatric Formulary provided the opportunity to develop an integrated paediatric dose calculator. In a simulated setting, we tested the ability of this calculator to reduce c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e822dc3c4fd7dcc6be59e243bf7e6501
https://pure.eur.nl/en/publications/e27105c8-165e-4abf-8bc1-e55435dbda63

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Size matters

Publikováno v: PLoS Genetics, Vol 17, Iss 8, p e1009698 (2021)
PLoS Genetics, 17(8):1009698. Public Library of Science
PLoS Genetics

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ffd6b90755de1ab4d3626dcb53e08d4
http://www.scopus.com/inward/record.url?scp=85114296624&partnerID=8YFLogxK

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P68 Significant oral drug use in critically ill children: rational therapy or a black box?

Autor: Miriam G. Mooij, J van Rosmalen, Dick Tibboel, SN de Wildt, Lidwien M. Hanff, Jonathan D. Windster

Publikováno v: Archives of Disease in Childhood. 104:e45.2-e45

BackgroundThe disposition of orally prescribed drugs in critically ill children may be affected critical illness in in addition to age, resulting in erratic effects and safety. We aimed to study oral drug prescribing in the neonatal and pediatric int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::092fb60d1ef1ae2074dde32b89d15c58
https://doi.org/10.1136/archdischild-2019-esdppp.106

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Proteomic Analysis of the Developmental Trajectory of Human Hepatic Membrane Transporter Proteins in the First Three Months of Life

Autor: Barbara A. E. de Koning, Wouter H. Vaes, Jonathan D. Windster, Saskia N. de Wildt, Joost van Rosmalen, Bianca D van Groen, Dick Tibboel, Miriam G. Mooij, Heleen M. Wortelboer, Evita van de Steeg

Publikováno v: Drug Metabolism and Disposition, 44, 1005-13
Drug Metabolism and Disposition, 44, 7, pp. 1005-13
Drug Metabolism and Disposition, 7, 44, 1005-1013
Drug Metabolism & Disposition, 44(7), 1005-1013. American Society for Pharmacology and Experimental Therapeutics

Human hepatic membrane-embedded transporter proteins are involved in trafficking endogenous and exogenous substrates. Even though impact of transporters on pharmacokinetics is recognized, little is known on maturation of transporter protein expressio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b434a996814d6d61242a199f7dcb18
http://hdl.handle.net/2066/171296

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