Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Jonathan D Schertzer"'
Autor:
Emmanuel Denou, Karine Lolmède, Lucile Garidou, Celine Pomie, Chantal Chabo, Trevor C Lau, Morgan D Fullerton, Giulia Nigro, Alexia Zakaroff‐Girard, Elodie Luche, Céline Garret, Matteo Serino, Jacques Amar, Michael Courtney, Joseph F Cavallari, Brandyn D Henriksbo, Nicole G Barra, Kevin P Foley, Joseph B McPhee, Brittany M Duggan, Hayley M O'Neill, Amanda J Lee, Philippe Sansonetti, Ali A Ashkar, Waliul I Khan, Michael G Surette, Anne Bouloumié, Gregory R Steinberg, Rémy Burcelin, Jonathan D Schertzer
Publikováno v:
EMBO Molecular Medicine, Vol 7, Iss 3, Pp 259-274 (2015)
Abstract Pattern recognition receptors link metabolite and bacteria‐derived inflammation to insulin resistance during obesity. We demonstrate that NOD2 detection of bacterial cell wall peptidoglycan (PGN) regulates metabolic inflammation and insuli
Externí odkaz:
https://doaj.org/article/1803a973f117402abe470b9a81cd7cf9
Autor:
Irena A Rebalka, Matthew J Raleigh, Laelie A Snook, Alexandra N Rebalka, Rebecca EK MacPherson, David C Wright, Jonathan D Schertzer, Thomas J Hawke
Publikováno v:
Frontiers in Endocrinology, Vol 7 (2016)
While statins significantly reduce cholesterol levels and thereby reduce the risk of cardiovascular disease, the development of myopathy with statin use is a significant clinical side-effect. Recent guidelines recommend increasing inclusion criteria
Externí odkaz:
https://doaj.org/article/3ee13a09d08c48dd978a91d98abcdee5
Autor:
Wendy Chi, Dyda Dao, Trevor C Lau, Brandyn D Henriksbo, Joseph F Cavallari, Kevin P Foley, Jonathan D Schertzer
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97675 (2014)
Obesity is associated with inflammation that can drive metabolic defects such as hyperlipidemia and insulin resistance. Specific metabolites can contribute to inflammation, but nutrient intake and obesity are also associated with altered bacterial lo
Externí odkaz:
https://doaj.org/article/e4a927ea0bac4be0b8ca14c3073af4c6
Autor:
Yun Han Kwon, Suhrid Banskota, Huaqing Wang, Laura Rossi, Jensine A. Grondin, Saad A. Syed, Yeganeh Yousefi, Jonathan D. Schertzer, Katherine M. Morrison, Michael G. Wade, Alison C. Holloway, Michael G. Surette, Gregory R. Steinberg, Waliul I. Khan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Abstract Chemicals in food are widely used leading to significant human exposure. Allura Red AC (AR) is a highly common synthetic colorant; however, little is known about its impact on colitis. Here, we show chronic exposure of AR at a dose found in
Externí odkaz:
https://doaj.org/article/e22bc7fbc4f04c989edfbdc65e3e4ed2
Autor:
Brittany M. Duggan, Akhilesh K. Tamrakar, Nicole G. Barra, Fernando F. Anhê, Gabriella Paniccia, Jessica G. Wallace, Hannah D. Stacey, Michael G. Surette, Matthew S. Miller, Deborah M. Sloboda, Jonathan D. Schertzer
Publikováno v:
Molecular Metabolism, Vol 55, Iss , Pp 101404- (2022)
Objective: Obesity and diabetes increase circulating levels of microbial components derived from the gut microbiota. Individual bacterial factors (i.e., postbiotics) can have opposing effects on blood glucose. Methods: We tested the net effect of gut
Externí odkaz:
https://doaj.org/article/0ecfcb494020486c9c9f21ee6d28b730
Autor:
Fernando F. Anhê, Nicole G. Barra, Joseph F. Cavallari, Brandyn D. Henriksbo, Jonathan D. Schertzer
Publikováno v:
Cell Reports, Vol 36, Iss 11, Pp 109691- (2021)
Summary: Lipopolysaccharides (LPSs) can promote metabolic endotoxemia, which is considered inflammatory and metabolically detrimental based on Toll-like receptor (TLR)4 agonists, such as Escherichia coli-derived LPS. LPSs from certain bacteria antago
Externí odkaz:
https://doaj.org/article/8232242716ab450f8f3e31a20afcd027
Autor:
Basma A. Ahmed, Frank J. Ong, Nicole G. Barra, Denis P. Blondin, Elizabeth Gunn, Stephan M. Oreskovich, Jake C. Szamosi, Saad A. Syed, Emily K. Hutchings, Norman B. Konyer, Nina P. Singh, Julian M. Yabut, Eric M. Desjardins, Fernando F. Anhê, Kevin P. Foley, Alison C. Holloway, Michael D. Noseworthy, Francois Haman, Andre C. Carpentier, Michael G. Surette, Jonathan D. Schertzer, Zubin Punthakee, Gregory R. Steinberg, Katherine M. Morrison
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 9, Pp 100397- (2021)
Summary: In rodents, lower brown adipose tissue (BAT) activity is associated with greater liver steatosis and changes in the gut microbiome. However, little is known about these relationships in humans. In adults (n = 60), we assessed hepatic fat and
Externí odkaz:
https://doaj.org/article/3f605dad37834d20b7e3330887e81098
Autor:
Kevin P. Foley, Soumaya Zlitni, Brittany M. Duggan, Nicole G. Barra, Fernando F. Anhê, Joseph F. Cavallari, Brandyn D. Henriksbo, Cassandra Y. Chen, Michael Huang, Trevor C. Lau, Roxanne Plante, Michael Schwab, André Marette, Jonathan D. Schertzer
Publikováno v:
Molecular Metabolism, Vol 42, Iss , Pp 101067- (2020)
Objective: Hyperinsulinemia can be both a cause and consequence of obesity and insulin resistance. Hyperinsulinemia can result from increased insulin secretion and/or reduced insulin clearance. While many studies have focused on mechanisms triggering
Externí odkaz:
https://doaj.org/article/3bb6076afe67426189c727075f279b40
Long term but not short term exposure to obesity related microbiota promotes host insulin resistance
Autor:
Kevin P. Foley, Soumaya Zlitni, Emmanuel Denou, Brittany M. Duggan, Rebecca W. Chan, Jennifer C. Stearns, Jonathan D. Schertzer
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Gut microbiota impact host metabolism and gut microbiome composition reflects dietary habits. Here the authors show that, in animals fed obesogenic diets, changes in gut microbiota precede changes in glucose homeostasis. Importantly, long term exposu
Externí odkaz:
https://doaj.org/article/68c512e1d99244659534527c1f401cb8
Publikováno v:
Journal of Obesity & Metabolic Syndrome, Vol 26, Iss 3, Pp 161-171 (2017)
Obesity is associated with increased risk of developing metabolic diseases such as type 2 diabetes. The origins of obesity are multi-factorial, but ultimately rooted in increased host energy accumulation or retention. The gut microbiota has been impl
Externí odkaz:
https://doaj.org/article/2aadcc37bca74fd094563475541dd72a