Zobrazeno 1 - 10
of 246
pro vyhledávání: '"Jonathan D Powell"'
Autor:
Christine L Vigeland, Samuel L Collins, Yee Chan-Li, Andrew H Hughes, Min-Hee Oh, Jonathan D Powell, Maureen R Horton
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163288 (2016)
Pulmonary fibrosis is a devastating, incurable disease in which chronic inflammation and dysregulated, excessive wound healing lead to progressive fibrosis, lung dysfunction, and ultimately death. Prior studies have implicated the cytokine IL-17A and
Externí odkaz:
https://doaj.org/article/ba285b184aa34eeeb91fa60134a0fa9a
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0121710 (2015)
mTOR is a central integrator of metabolic and immunological stimuli, dictating immune cell activation, proliferation and differentiation. In this study, we demonstrate that within a clonal population of activated T cells, there exist both mTORhi and
Externí odkaz:
https://doaj.org/article/15ac67622a764fe0b126e909a90adbb5
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87265 (2014)
The transcription factor Early Growth Response 3 (Egr3) has been shown to play an important role in negatively regulating T cell activation and promoting T cell anergy in Th1 cells. However, its role in regulating other T helper subsets has yet to be
Externí odkaz:
https://doaj.org/article/9ad8ff6395b34316aea8c5f5bf096774
Autor:
Sam Collins, Adam Waickman, Albert Basson, Abraham Kupfer, Jonathan D Licht, Maureen R Horton, Jonathan D Powell
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49801 (2012)
TCR-induced NF-AT activation leads to the expression of both activating and inhibitory proteins. Previously, we had identified Egr-2 and Egr-3 as NF-AT-induced transcription factors which promote the inhibition of T cell activation. In this report we
Externí odkaz:
https://doaj.org/article/16e44b9a4e1a4b13a5ae054cc44c060d
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31299 (2012)
Pulmonary fibrosis is an untreatable, uniformly fatal disease of unclear etiology that is the result of unremitting chronic inflammation. Recent studies have implicated bone marrow derived fibrocytes and M2 macrophages as playing key roles in propaga
Externí odkaz:
https://doaj.org/article/577ea467bc9c4a77b97e1b2aeb2f5104
Autor:
Sadiya Parveen, Jessica Shen, Shichun Lun, Liang Zhao, Jesse Alt, Benjamin Koleske, Robert D. Leone, Rana Rais, Jonathan D. Powell, John R. Murphy, Barbara S. Slusher, William R. Bishai
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract As one of the most successful human pathogens, Mycobacterium tuberculosis (Mtb) has evolved a diverse array of determinants to subvert host immunity and alter host metabolic patterns. However, the mechanisms of pathogen interference with hos
Externí odkaz:
https://doaj.org/article/5ee43a946d644d098c99d5f9a66e0bac
Autor:
Chirag H. Patel, Yi Dong, Navid Koleini, Xiaoxu Wang, Brittany L. Dunkerly-Eyring, Jiayu Wen, Mark J. Ranek, Laura M. Bartle, Daniel B. Henderson, Jason Sagert, David A. Kass, Jonathan D. Powell
Publikováno v:
JCI Insight, Vol 8, Iss 21 (2023)
MTORC1 integrates signaling from the immune microenvironment to regulate T cell activation, differentiation, and function. TSC2 in the tuberous sclerosis complex tightly regulates mTORC1 activation. CD8+ T cells lacking TSC2 have constitutively enhan
Externí odkaz:
https://doaj.org/article/a083a4cf862f46bbaf2d18318431aee5
Autor:
Kevin M. Motz, Ioan A. Lina, Idris Samad, Michael K. Murphy, Madhavi Duvvuri, Ruth J. Davis, Alexander Gelbard, Liam Chung, Yee Chan-Li, Samuel Collins, Jonathan D. Powell, Jennifer H. Elisseeff, Maureen R. Horton, Alexander T. Hillel
Publikováno v:
JCI Insight, Vol 8, Iss 11 (2023)
Laryngotracheal stenosis (LTS) is pathologic fibrotic narrowing of the larynx and trachea characterized by hypermetabolic fibroblasts and CD4+ T cell–mediated inflammation. However, the role of CD4+ T cells in promoting LTS fibrosis is unknown. The
Externí odkaz:
https://doaj.org/article/89ce5a887c6b4f738d6058bd9b2c232a
Autor:
Alok Kumar Singh, Monali Praharaj, Kara A. Lombardo, Takahiro Yoshida, Andres Matoso, Alex S. Baras, Liang Zhao, Geetha Srikrishna, Joy Huang, Pankaj Prasad, Jonathan D. Powell, Max Kates, David McConkey, Drew M. Pardoll, William R. Bishai, Trinity J. Bivalacqua
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Vaccination with BCG has been shown to induce a pre-priming effect in innate immune cells termed trained immunity. Here the authors re-engineer the BCG vaccine and show augmented immune responses, enhanced induction of trained immunity and improved a
Externí odkaz:
https://doaj.org/article/9db61455ef9942dd88ce427f39092448
Autor:
Wei Xu, Chirag H. Patel, Liang Zhao, Im-Hong Sun, Min-Hee Oh, Im-Meng Sun, Rachel S. Helms, Jiayu Wen, Jonathan D. Powell
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111987- (2023)
Summary: T cell activation, proliferation, function, and differentiation are tightly linked to proper metabolic reprogramming and regulation. By using [U-13C]glucose tracing, we reveal a critical role for GOT1 in promoting CD8+ T cell effector differ
Externí odkaz:
https://doaj.org/article/360b4aff873b4c358cd76307cf3b6215