Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jonathan D Gruber"'
Publikováno v:
PLoS Genetics, Vol 8, Iss 2, p e1002497 (2012)
Genetic variation within and between species can be shaped by population-level processes and mutation; however, the relative impact of "survival of the fittest" and "arrival of the fittest" on phenotypic evolution remains unclear. Assessing the influ
Externí odkaz:
https://doaj.org/article/ab104ef7c4d244a69d1e64def10c4f89
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23778 (2011)
BACKGROUND: Analysis of genomic sequence allows characterization of genome content and organization, and access beyond gene-coding regions for identification of functional elements. BAC libraries, where relatively large genomic regions are made readi
Externí odkaz:
https://doaj.org/article/3f9b6312d90741779d78615de7b99a9f
Autor:
Jonathan D. Gruber, Tiffany E. Brooks, Patricia J. Wittkopp, Natasha Sood, Brian P. H. Metzger, Katya L. Mack, Fabien Duveau
Publikováno v:
G3: Genes|Genomes|Genetics
Genetic variants identified by mapping are biased toward large phenotypic effects because of methodologic challenges for detecting genetic variants with small phenotypic effects. Recently, bulk segregant analysis combined with next-generation sequenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::834b2411e68d6e641b3c4c6884311604
http://europepmc.org/articles/PMC4455770
http://europepmc.org/articles/PMC4455770
Autor:
Chad Nusbaum, Christian R. Landry, Carsten Russ, Jonathan D. Gruber, Pierre Fontanillas, Patricia J. Wittkopp, Daniel L. Hartl
Publikováno v:
Molecular Ecology. 19:212-227
Differences in gene expression are thought to be an important source of phenotypic diversity, so dissecting the genetic components of natural variation in gene expression is important for understanding the evolutionary mechanisms that lead to adaptat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11c127e22e271b9a1f6759b2fb1219de
https://doi.org/10.1111/j.1365-294x.2010.04472.x
https://doi.org/10.1111/j.1365-294x.2010.04472.x
Publikováno v:
Genetics. 175:1987-1997
Currently, the relevance of common genetic variants—particularly those significantly associated with phenotypic variation in laboratory studies—to standing phenotypic variation in the wild is poorly understood. To address this, we quantified the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acff78db0d955e02b0c66823065f4d7c
https://doi.org/10.1534/genetics.106.067108
https://doi.org/10.1534/genetics.106.067108
Autor:
Yuji Matsuzawa, Sachiyo Tanaka, Farook Thameem, Tohru Funahashi, Robert L. Hanson, Barbora de Courten, Robert S. Lindsay, Jonathan D. Gruber, Philippe Froguel, Johanna K. Wolford
Publikováno v:
ResearcherID
Adiponectin is an abundant adipose tissue-derived protein with important metabolic effects. Plasma adiponectin levels are decreased in obese individuals, and low adiponectin levels predict insulin resistance and type 2 diabetes. Two variants in the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cd572fa7a5b9897a0d84bb75af25fd2
https://doi.org/10.2337/diabetes.54.1.284
https://doi.org/10.2337/diabetes.54.1.284
Autor:
Clifton Bogardus, Jonathan D. Gruber, V. Ossowski, P. Antonio Tataranni, Barbora Vozarova, Robert L. Hanson, Johanna K. Wolford
Publikováno v:
Molecular Genetics and Metabolism. 78:136-144
Linkage analysis has identified a susceptibility locus for type 2 diabetes mellitus (T2DM) on chromosome 1q21–q23 in several populations. Results from recent prospective studies indicate that increased levels of C-reactive protein (CRP), a marker o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac6d9c40feb67795061c7cd3ddc1d471
https://doi.org/10.1016/s1096-7192(02)00230-5
https://doi.org/10.1016/s1096-7192(02)00230-5
Publikováno v:
Nature
Quantifying activity of cis-regulatory sequences controlling gene expression shows that selection on expression noise has a greater impact on sequence variation than selection on mean expression level. Patricia Wittkopp and colleagues measure and com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c05058245ed91a4fa9c520c1f435481
https://pubmed.ncbi.nlm.nih.gov/25778704
https://pubmed.ncbi.nlm.nih.gov/25778704
Autor:
Jonathan D, Gruber
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 700
Genome-wide association studies are providing exciting new insight into the genetics of complex disease, but oftentimes, the genomic regions associated with the trait of interest are large enough to contain several equally plausible candidate genes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0ddd7c0ad58640b1a83e8bf1d3cbdcbd
https://pubmed.ncbi.nlm.nih.gov/21204033
https://pubmed.ncbi.nlm.nih.gov/21204033
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23778 (2011)
Conceicao, Ines C.; Long, Anthony D.; Gruber, Jonathan D.; & Beldade, Patricia. (2011). Genomic Sequence around Butterfly Wing Development Genes: Annotation and Comparative Analysis. PLoS ONE, 6(8), e23778. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/25p8w6sw
PLoS ONE
Conceicao, Ines C.; Long, Anthony D.; Gruber, Jonathan D.; & Beldade, Patricia. (2011). Genomic Sequence around Butterfly Wing Development Genes: Annotation and Comparative Analysis. PLoS ONE, 6(8), e23778. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/25p8w6sw
PLoS ONE
BACKGROUND: Analysis of genomic sequence allows characterization of genome content and organization, and access beyond gene-coding regions for identification of functional elements. BAC libraries, where relatively large genomic regions are made readi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6058ab7dcf5e3b82241b9f6dbc499d3a
http://europepmc.org/articles/PMC3166123?pdf=render
http://europepmc.org/articles/PMC3166123?pdf=render