Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Jonathan D F Wadsworth"'
Autor:
Emmanuel A Asante, Jacqueline M Linehan, Andrew Tomlinson, Tatiana Jakubcova, Shyma Hamdan, Andrew Grimshaw, Michelle Smidak, Asif Jeelani, Akin Nihat, Simon Mead, Sebastian Brandner, Jonathan D F Wadsworth, John Collinge
Publikováno v:
PLoS Biology, Vol 18, Iss 6, p e3000725 (2020)
Inherited prion diseases are caused by autosomal dominant coding mutations in the human prion protein (PrP) gene (PRNP) and account for about 15% of human prion disease cases worldwide. The proposed mechanism is that the mutation predisposes to confo
Externí odkaz:
https://doaj.org/article/23162b9d52f24df19f6d1cd295aceaa2
Autor:
Emmanuel A Asante, Andrew Grimshaw, Michelle Smidak, Tatiana Jakubcova, Andrew Tomlinson, Asif Jeelani, Shyma Hamdan, Caroline Powell, Susan Joiner, Jacqueline M Linehan, Sebastian Brandner, Jonathan D F Wadsworth, John Collinge
Publikováno v:
PLoS Pathogens, Vol 11, Iss 7, p e1004953 (2015)
Inherited prion disease (IPD) is caused by autosomal-dominant pathogenic mutations in the human prion protein (PrP) gene (PRNP). A proline to leucine substitution at PrP residue 102 (P102L) is classically associated with Gerstmann-Sträussler-Scheink
Externí odkaz:
https://doaj.org/article/cbedaacc47634d168258a9c11682a9a1
Autor:
Emmanuel A Asante, Jacqueline M Linehan, Michelle Smidak, Andrew Tomlinson, Andrew Grimshaw, Asif Jeelani, Tatiana Jakubcova, Shyma Hamdan, Caroline Powell, Sebastian Brandner, Jonathan D F Wadsworth, John Collinge
Publikováno v:
PLoS Pathogens, Vol 9, Iss 9, p e1003643 (2013)
Prions are infectious agents causing fatal neurodegenerative diseases of humans and animals. In humans, these have sporadic, acquired and inherited aetiologies. The inherited prion diseases are caused by one of over 30 coding mutations in the human p
Externí odkaz:
https://doaj.org/article/1653ee8f3d5d48f2b5bd5437c7915f67
Autor:
Laura D'Castro, Adam Wenborn, Nathalie Gros, Susan Joiner, Sabrina Cronier, John Collinge, Jonathan D F Wadsworth
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15679 (2010)
Disease-related prion protein, PrP(Sc), is classically distinguished from its normal cellular precursor, PrP(C), by its detergent insolubility and partial resistance to proteolysis. Molecular diagnosis of prion disease typically relies upon detection
Externí odkaz:
https://doaj.org/article/b342d1c5b92d4a38a2135ea008355eed
Autor:
Szymon W. Manka, Wenjuan Zhang, Adam Wenborn, Jemma Betts, Susan Joiner, Helen R. Saibil, John Collinge, Jonathan D. F. Wadsworth
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
High-resolution structures of mammalian prions have remained elusive. Here, Manka et al. report the cryo-EM structure of infectious RML prion fibrils from mice. Structural similarity with recently reported infectious 263K prion fibrils from hamsters
Externí odkaz:
https://doaj.org/article/9b6eb942195b4bc19be04c9aa47b9d02
Publikováno v:
Cell and Tissue Research. 392:167-178
Mammalian prions are lethal transmissible pathogens that cause fatal neurodegenerative diseases in humans and animals. They consist of fibrils of misfolded, host-encoded prion protein (PrP) which propagate through templated protein polymerisation. Pr
Autor:
Graham S. Jackson, Jacqueline Linehan, Sebastian Brandner, Emmanuel A. Asante, Jonathan D. F. Wadsworth, John Collinge
Publikováno v:
Scientific Reports. 12
Transgenic mice over-expressing human PRNP or murine Prnp transgenes on a mouse prion protein knockout background have made key contributions to the understanding of human prion diseases and have provided the basis for many of the fundamental advance
Autor:
Emmanuel A. Asante, Kezia Jack, Maged Taema, Fuquan Zhang, Jørn Våge, Thea Ingold, Malin K. Sandberg, Bjørnar Ytrehus, Helena Costa, Linh T. Tran, Knut Madslien, Sebastian Brandner, Sylvie L. Benestad, Susan Joiner, Jacqueline M. Linehan, Jonathan D. F. Wadsworth, Turid Vikøren, Huda Al-Doujaily, John Collinge
Publikováno v:
The Journal of infectious diseases. 226(5)
Chronic wasting disease (CWD) is the transmissible spongiform encephalopathy or prion disease affecting cervids. In 2016, the first cases of CWD were reported in Europe in Norwegian wild reindeer and moose. The origin and zoonotic potential of these
Autor:
Parmjit S. Jat, Huda Al-Doujaily, Aline T Marinho, Jonathan D. F. Wadsworth, Madeleine Reilly, Iryna Benilova, Adam Wenborn, Emmanuel Risse, Christian Schmidt, Michael Wiggins De Oliveira, Cassandra Terry, John Collinge, Malin K. Sandberg
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Prions are infectious agents composed of polymers of misfolded prion protein which cause fatal brain diseases such as Creutzfeldt–Jakob disease. These diseases involve progressive loss of neuronal cells, and it has been long assumed th
Autor:
Sabrina Cronier, Anthony R. Clarke, John Collinge, Graham S. Jackson, Jonathan D. F. Wadsworth, M. Howard Tattum, Nathalie Gros
Publikováno v:
UK Funders’ TSE Workshop
UK Funders’ TSE Workshop, Labo/service de l'auteur, Ville service., Oct 1999, Warwick, United Kingdom. pp.Inconnu
Biochemical Journal
UK Funders’ TSE Workshop, Labo/service de l'auteur, Ville service., Oct 1999, Warwick, United Kingdom. pp.Inconnu
Biochemical Journal
Disease-related PrP(Sc) [pathogenic PrP (prion protein)] is classically distinguished from its normal cellular precursor, PrP(C)(cellular PrP) by its detergent insolubility and partial resistance to proteolysis. Although molecular diagnosis of prion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4111cf3755a12dc833b8d1db20cb7ed5
https://hal.inrae.fr/hal-02812714
https://hal.inrae.fr/hal-02812714