Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Jonathan Coxhead"'
Autor:
Marina Moya-Molina, Birthe Dorgau, Emily Flood, Stef J. F. Letteboer, Esben Lorentzen, Jonathan Coxhead, Graham Smith, Ronald Roepman, Sushma Nagaraja Grellscheid, Lyle Armstrong, Majlinda Lako
Publikováno v:
Cell Death and Disease, Vol 15, Iss 10, Pp 1-17 (2024)
Abstract Alternative splicing (AS) is a crucial mechanism contributing to proteomic diversity, which is highly regulated in tissue- and development-specific patterns. Retinal tissue exhibits one of the highest levels of AS. In particular, photorecept
Externí odkaz:
https://doaj.org/article/6ac21c2cb7924f1387437c17d929f6bd
Autor:
Sophie J. Gilbert, Jamie Soul, Yao Hao, Hua Lin, Katarzyna A. Piróg, Jonathan Coxhead, Krutik Patel, Matt J. Barter, David A. Young, Emma J. Blain
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 10 (2024)
Externí odkaz:
https://doaj.org/article/7bf1a9b2e6434f3e83dabd80f2d1187f
Autor:
Birthe Dorgau, Joseph Collin, Agata Rozanska, Darin Zerti, Adrienne Unsworth, Moira Crosier, Rafiqul Hussain, Jonathan Coxhead, Tamil Dhanaseelan, Aara Patel, Jane C. Sowden, David R. FitzPatrick, Rachel Queen, Majlinda Lako
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The emergence of retinal progenitor cells and differentiation to various retinal cell types represent fundamental processes during retinal development. Herein, we provide a comprehensive single cell characterisation of transcriptional and ch
Externí odkaz:
https://doaj.org/article/416ae52d4d2147ef83f5da46162b46af
Autor:
Kenneth F. Baker, David McDonald, Gillian Hulme, Rafiqul Hussain, Jonathan Coxhead, David Swan, Axel R. Schulz, Henrik E. Mei, Lucy MacDonald, Arthur G. Pratt, Andrew Filby, Amy E. Anderson, John D. Isaacs
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Immune-mediated inflammatory diseases (IMIDs) are typically characterised by relapsing and remitting flares of inflammation. However, the unpredictability of disease flares impedes their study. Addressing this critical knowledge gap, we use
Externí odkaz:
https://doaj.org/article/34a7ab6817b24901ae14c64e18ae1869
Autor:
Birthe Dorgau, Joseph Collin, Agata Rozanska, Veronika Boczonadi, Marina Moya-Molina, Adrienne Unsworth, Rafiqul Hussain, Jonathan Coxhead, Tamil Dhanaseelan, Lyle Armstrong, Rachel Queen, Majlinda Lako
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109397- (2024)
Summary: Molecular information on the early stages of human retinal development remains scarce due to limitations in obtaining early human eye samples. Pluripotent stem cell-derived retinal organoids (ROs) provide an unprecedented opportunity for stu
Externí odkaz:
https://doaj.org/article/75b0f3cd2f454035b6357992656fba5c
Autor:
Rachel Queen, Moira Crosier, Lorraine Eley, Janet Kerwin, Jasmin E Turner, Jianshi Yu, Ahlam Alqahtani, Tamilvendhan Dhanaseelan, Lynne Overman, Hannah Soetjoadi, Richard Baldock, Jonathan Coxhead, Veronika Boczonadi, Alex Laude, Simon J Cockell, Maureen A Kane, Steven Lisgo, Deborah J Henderson
Publikováno v:
PLoS Genetics, Vol 19, Iss 11, p e1010777 (2023)
Abnormalities of the arterial valves, including bicuspid aortic valve (BAV) are amongst the most common congenital defects and are a significant cause of morbidity as well as predisposition to disease in later life. Despite this, and compounded by th
Externí odkaz:
https://doaj.org/article/dfe20b71ab304eefbcc80b295256055d
Autor:
Catherine F. Hatton, Rachel A. Botting, Maria Emilia Dueñas, Iram J. Haq, Bernard Verdon, Benjamin J. Thompson, Jarmila Stremenova Spegarova, Florian Gothe, Emily Stephenson, Aaron I. Gardner, Sandra Murphy, Jonathan Scott, James P. Garnett, Sean Carrie, Jason Powell, C. M. Anjam Khan, Lei Huang, Rafiqul Hussain, Jonathan Coxhead, Tracey Davey, A. John Simpson, Muzlifah Haniffa, Sophie Hambleton, Malcolm Brodlie, Chris Ward, Matthias Trost, Gary Reynolds, Christopher J. A. Duncan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The innate immune response in epithelial cells after SARS-CoV-2 infection is not fully understood. Here the authors use human air-liquid interface culture and show single cell transcription changes and delayed type I Interferon responses after SARS-C
Externí odkaz:
https://doaj.org/article/0c29a923bed447a88b3b4df91dd15100
Autor:
Marzena Kurzawa‐Akanbi, Phillip Whitfield, Florence Burté, Pietro Maria Bertelli, Varun Pathak, Mary Doherty, Birthe Hilgen, Lina Gliaudelytė, Mark Platt, Rachel Queen, Jonathan Coxhead, Andrew Porter, Maria Öberg, Daniela Fabrikova, Tracey Davey, Chia Shyan Beh, Maria Georgiou, Joseph Collin, Veronika Boczonadi, Anetta Härtlova, Michael Taggart, Jumana Al‐Aama, Viktor I Korolchuk, Christopher M Morris, Jasenka Guduric‐Fuchs, David H Steel, Reinhold J Medina, Lyle Armstrong, Majlinda Lako
Publikováno v:
Journal of Extracellular Vesicles, Vol 11, Iss 12, Pp n/a-n/a (2022)
Abstract Age‐related macular degeneration (AMD) is a leading cause of blindness. Vision loss is caused by the retinal pigment epithelium (RPE) and photoreceptors atrophy and/or retinal and choroidal angiogenesis. Here we use AMD patient‐specific
Externí odkaz:
https://doaj.org/article/1398b9e7c68548ba80b5a5b5d9c80bee
Autor:
Claudia Calabrese, Angela Pyle, Helen Griffin, Jonathan Coxhead, Rafiqul Hussain, Peter S Braund, Linxin Li, Annette Burgess, Patricia B Munroe, Louis Little, Helen R Warren, Claudia Cabrera, Alistair Hall, Mark J Caulfield, Peter M Rothwell, Nilesh J Samani, Gavin Hudson, Patrick F Chinnery
Publikováno v:
PLoS Genetics, Vol 18, Iss 4, p e1010068 (2022)
Mitochondria are implicated in the pathogenesis of cardiovascular diseases (CVDs) but the reasons for this are not well understood. Maternally-inherited population variants of mitochondrial DNA (mtDNA) which affect all mtDNA molecules (homoplasmic) a
Externí odkaz:
https://doaj.org/article/024869c07de9440983db87b9f466acd3
Autor:
Helen R. Davies, Kirsty Hodgson, Edward Schwalbe, Jonathan Coxhead, Naomi Sinclair, Xueqing Zou, Simon Cockell, Akhtar Husain, Serena Nik-Zainal, Neil Rajan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
CYLD cutaneous syndrome (also known as Brooke-Spiegler syndrome) is characterised by germline mutations in the tumor suppressor CYLD. Here, the authors highlight recurrent mutations in DNMT3A and BCOR, indicating a role for epigenetic dysregulation i
Externí odkaz:
https://doaj.org/article/455161ea0e7d48609e0545f51dafe8d6