Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Jonathan Coffman"'
Publikováno v:
Case Reports in Medicine, Vol 2016 (2016)
Background. Recently, the importance of the gut microbiota in the pathogenesis of several disorders has gained clinical interests. Among exogenous factors affecting gut microbiome, diet appears to have the largest effect. Fatty acids, especially omeg
Externí odkaz:
https://doaj.org/article/3de1d44afe3f48f3895211966cf3046c
Autor:
Steven Rose, Sevda Deldari, Maen Qadan, Lisa Connell-Crowley, Jonathan Coffman, Ujwal Patil, David Pollard, Joseph Shultz, Brian Horowski, Mark Brower, Suzanne S. Farid, Eugene Schaefer
Publikováno v:
Biotechnology and Bioengineering
There is a growing application of integrated and continuous bioprocessing (ICB) for manufacturing recombinant protein therapeutics produced from mammalian cells. At first glance, the newly evolved ICB has created a vast diversity of platforms. A clos
Autor:
Rushd Khalaf, Neil Mody, Bruno F. Marques, Steven M. Cramer, Christopher D. Afdahl, Richard C. Willson, Jennifer M. Pollard, Eike Zimmermann, Jan Griesbach, Divya Chandra, Charles A. Haynes, Kannan Sankar, Ujwal Patil, Jonathan Coffman, Hasan Mohammad, Joelle Khouri, Minni Aswath, Jasper C. Lin, Lars Pampel, Alexander Hanke, Siddharth Parimal, David J. Roush, Francis Insaidoo, Saeed Izadi, Raquel Orozco, Soundara Soundararajan, Nihal Tugcu, Gisela Ferreira, Tingting Cui, John P. Welsh, Jainik Panchal, Ambrose Williams, Stefan Hepbildikler, Xuan Hong, Julie Robinson, Marco A. Blanco, John E. Schiel, Jared A. Delmar, Benjamin T. Walters
Publikováno v:
Biotechnology and Bioengineering. 117:2100-2115
Biopharmaceutical product and process development do not yet take advantage of predictive computational modeling to nearly the degree seen in industries based on smaller molecules. To assess and advance progress in this area, spirited coopetition (mu
Publikováno v:
Biotechnology progressREFERENCES. 37(1)
Precipitation can be used for the initial purification of monoclonal antibodies (mAbs), with the soluble host cell proteins removed in the permeate by tangential flow microfiltration. The objective of this study was to examine the use of a feed-and-b
Autor:
Justin A. Beller, John Schmitt, Margot Cortese, Jeffrey F. Breit, Eike Zimmermann, Jonathan Coffman, Kenji Furuya, Jeffrey D. Goby
Publikováno v:
Biotechnology Progress. 36
Acidic virus inactivation is commonly used during production of biotherapeutic products to provide virus safety in case of undetected virus contamination. Accurate pH measurement is required to ensure the product pH reaches a virus-inactivating level
Publikováno v:
Biotechnology progressREFERENCES. 36(6)
As upstream product titers increase, the downstream chromatographic capture step has become a significant "downstream bottleneck." Precipitation becomes more attractive under these conditions as the supersaturation driving force increases with the ev
Autor:
Jonathan Coffman, Graham P. Shaw
Publikováno v:
Journal of the American Podiatric Medical Association. 107:65-71
Attrition from medical school remains a serious cause of concern for the medical education community. Thus, there is a need to improve our ability to select only those candidates who will succeed at medical school from many highly qualified and motiv
Publikováno v:
Biotechnology Progress. 35
There is renewed interest in the possibility of using precipitation for initial capture of high-value therapeutic proteins as part of an integrated continuous downstream process. Precipitation is greatly facilitated by the high product titers now ach
Autor:
Khurram Sunasara, Aaron Noyes, Nick Merchant, Nigel J. Titchener-Hooker, Ben Huffman, Ranga Godavarti, Jonathan Coffman, Tarit Mukhopadhyay, Alex Berrill
Publikováno v:
Biotechnology and Bioengineering. 112:1568-1582
Multivalent polysaccharide conjugate vaccines are typically comprised of several different polysaccharides produced with distinct and complex production processes. Particle conditioning steps, such as precipitation and flocculation, may be used to ai
Autor:
Ranga Godavarti, Nigel J. Titchener-Hooker, Jonathan Coffman, Khurram Sunasara, Ben Huffman, Aaron Noyes, Tarit Mukhopadhyay
Publikováno v:
Biotechnology and Bioengineering. 112:1554-1567
The biotech industry is under increasing pressure to decrease both time to market and development costs. Simultaneously, regulators are expecting increased process understanding. High throughput process development (HTPD) employs small volumes, paral