Zobrazeno 1 - 10
of 328
pro vyhledávání: '"Jonathan Chou"'
Autor:
Tanya Jindal, Xiaolin Zhu, Rohit Bose, Vipul Kumar, Edward Maldonado, Prianka Deshmukh, Chase Shipp, Stephanie Feng, Michelle S. Johnson, Austin Angelidakis, Daniel Kwon, Hala T. Borno, Ivan de Kouchkovsky, Arpita Desai, Rahul Aggarwal, Lawrence Fong, Eric J. Small, Anthony Wong, Sima Porten, Jonathan Chou, Terence Friedlander, Vadim S. Koshkin
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundEnfortumab vedotin (EV) is an antibody-drug conjugate approved for patients with treatment-refractory advanced urothelial carcinoma (aUC), however data on biomarkers of response is lacking.MethodsWe retrospectively identified all aUC patien
Externí odkaz:
https://doaj.org/article/807b9f7db97e495ebdc50bd69421c109
Autor:
Rajdeep Das, Martin Sjöström, Raunak Shrestha, Christopher Yogodzinski, Emily A. Egusa, Lisa N. Chesner, William S. Chen, Jonathan Chou, Donna K. Dang, Jason T. Swinderman, Alex Ge, Junjie T. Hua, Shaheen Kabir, David A. Quigley, Eric J. Small, Alan Ashworth, Felix Y. Feng, Luke A. Gilbert
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
It is hypothesized that there are a number of tumor specific driver genes for metastatic prostate cancer. Here, the authors perform genome-wide CRISPRi screens and integrate these data with metastatic prostate cancer functional and clinical genomics
Externí odkaz:
https://doaj.org/article/fa65632946e846318209a6540b59b6ba
Autor:
Divya Natesan, Li Zhang, Henry J. Martell, Tanya Jindal, Patrick Devine, Bradley Stohr, Carlos Espinosa-Mendez, James Grenert, Jessica Van Ziffle, Nancy Joseph, Sarah Umetsu, Courtney Onodera, Michelle Turski, Emily Chan, Arpita Desai, Rahul Aggarwal, Anthony Wong, Sima Porten, Jonathan Chou, Terence Friedlander, Lawrence Fong, Eric J. Small, Alejandro Sweet-Cordero, Vadim S. Koshkin
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
IntroductionTumor mutational burden (TMB) and APOBEC mutational signatures are potential prognostic markers in patients with advanced urothelial carcinoma (aUC). Their utility in predicting outcomes to specific therapies in aUC warrants additional st
Externí odkaz:
https://doaj.org/article/d5d36889a09849b4bd34fd75789880d6
Autor:
Li Zhang, Divya Natesan, Lawrence Fong, Emily Chan, David Y Oh, Son Ho, Ivan de Kouchkovsky, Errol J Philip, Francis Wright, Daniel M Kim, Daniel Kwon, Hansen Ho, Sima P Porten, Anthony C Wong, Arpita Desai, Franklin W Huang, Jonathan Chou, Raj S Pruthi, Eric J Small, Terence W Friedlander, Vadim S Koshkin
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 5 (2021)
Background Immune checkpoint inhibitors (ICI) can achieve durable responses in a subset of patients with locally advanced or metastatic urothelial carcinoma (aUC). The use of tumor genomic profiling in clinical practice may help suggest biomarkers to
Externí odkaz:
https://doaj.org/article/daffc1a2d771420089913bf03e6aaad2
Autor:
Bobba, Kondapa Naidu, Bidkar, Anil P., Wadhwa, Anju, Meher, Niranjan, Drona, Suchi, Sorlin, Alexandre M., Bidlingmaier, Scott, Li Zhang, Wilson, David M., Emily Chan, Greenland, Nancy Y., Aggarwal, Rahul, VanBrocklin, Henry F., Jiang He, Jonathan Chou, Youngho Seo, Bin Liu, Flavell, Robert R.
Publikováno v:
Theranostics; 2024, Vol. 14 Issue 4, p1344-1360, 17p
Autor:
Shalini Chopra, Kai Trepka, Sasank Sakhamuri, Alberto Carretero-González, Jun Zhu, Emily Egusa, Jie Zhou, Kevin Leung, Ning Zhao, Nima Hooshdaran, Felix Y. Feng, James A. Wells, Jonathan Chou, Michael J. Evans
Publikováno v:
Clinical Cancer Research. 29:1232-1242
Purpose: Despite recent approvals for checkpoint inhibitors and antibody–drug conjugates targeting NECTIN4 or TROP2, metastatic bladder cancer remains incurable and new treatment strategies are urgently needed. CUB domain–containing protein 1 (CD
Autor:
Jonathan Chou, Kai Trepka, Martin Sjöström, Emily A. Egusa, Carissa E. Chu, Jun Zhu, Emily Chan, Ewan A. Gibb, Michelle L. Badura, Alberto Contreras-Sanz, Bradley A. Stohr, Maxwell V. Meng, Raj S. Pruthi, Yair Lotan, Peter C. Black, Sima P. Porten, Vadim S. Koshkin, Terence W. Friedlander, Felix Y. Feng
Publikováno v:
European Urology Oncology. 5:714-718
Sacituzumab govitecan (SG) is an antibody-drug conjugate (ADC) targeting TROP2, which has recently been approved for treatment-refractory metastatic urothelial cancer (UC). However, the variability of TROP2 expression across different bladder cancer
Autor:
Jonathan Chou, Emily A. Egusa, Sinan Wang, Michelle L. Badura, Fei Lee, Anil P. Bidkar, Jun Zhu, Tanushree Shenoy, Kai Trepka, Troy M. Robinson, Veronica Steri, Jiaoti Huang, Yuzhuo Wang, Eric J. Small, Emily Chan, Bradley A. Stohr, Alan Ashworth, Brant Delafontaine, Sylvie Rottey, Keegan S. Cooke, Nooshin Hashemi Sadraei, Brian Yu, Mark Salvati, Julie M. Bailis, Felix Y. Feng, Robert R. Flavell, Rahul Aggarwal
Publikováno v:
Cancer Research. 83:301-315
Effective treatments for de novo and treatment-emergent small-cell/neuroendocrine (t-SCNC) prostate cancer represent an unmet need for this disease. Using metastatic biopsies from patients with advanced cancer, we demonstrate that delta-like ligand 3
Autor:
Yang Yang, Michelle L. Badura, Patrick O’Leary, Troy M. Robinson, Emily A. Egusa, Xiaoming Zhong, Jason T. Swinderman, Haolong Li, Meng Zhang, Minkyu Kim, Alan Ashworth, Felix Y. Feng, Jonathan Chou, Lixing Yang
Despite the abundance of somatic structural variations (SVs) in cancer, the underlying molecular mechanisms of their formation remain unclear. Here, we use 6,193 whole-genome sequenced tumors to study the contributions of transcription and DNA replic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f71620428625705bd160dfcf590bf5b
https://doi.org/10.1101/2023.05.17.23290140
https://doi.org/10.1101/2023.05.17.23290140
Autor:
Robert R. Flavell, Bin Liu, Jonathan Chou, Youngho Seo, Henry F. VanBrocklin, Rahul Aggarwal, David M. Wilson, Jiang He, Li Zhang, Ryan Tang, Yang Su, Denis Beckford-Vera, Chandrashekhar Dasari, Suchi Dhrona, Anju Wadhwa, Niranjan Meher, Umama Ali, Robin Peter, Emily A. Egusa, Scott Bidlingmaier, Emily Chan, Kondapa Naidu Bobba, Sinan Wang, Anil P. Bidkar
Figure S11: Antitumor activity of [225Ac]DOTA-YS5 in subcutaneous DU145 tumors in nude mice. Tumor volume, survival analysis, and weight measurements after the injections of [225Ac]DOTA-YS5 in DU145 xenografts (n=6).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::088b646bab868db70b2465e494a23059
https://doi.org/10.1158/1078-0432.22820111.v1
https://doi.org/10.1158/1078-0432.22820111.v1