Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Jonathan C. Zhao"'
Autor:
Galina Gritsina, Ka-wing Fong, Xiaodong Lu, Zhuoyuan Lin, Wanqing Xie, Shivani Agarwal, Dong Lin, Gary E. Schiltz, Himisha Beltran, Eva Corey, Colm Morrissey, Yuzhuo Wang, Jonathan C. Zhao, Maha Hussain, Jindan Yu
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 15 (2023)
CXCR7 is an atypical chemokine receptor that recruits β-arrestin (ARRB2) and internalizes into clathrin-coated intracellular vesicles where the complex acts as a scaffold for cytoplasmic kinase assembly and signal transduction. Here, we report that
Externí odkaz:
https://doaj.org/article/c997aecb55fc4d3096ec967527b396f3
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
TRIM24 is stabilized in SPOP-mutated prostate cancers, but the regulation of TRIM24 in wild-type prostate cancers is unknown. Here, the authors show that TRIM28 interacts with TRIM24 to prevent SPOP-mediated ubiquitination of TRIM24 and enhances TRIM
Externí odkaz:
https://doaj.org/article/a430e7c9c63d4512a8f2226634658d66
Autor:
Sen Zhu, Dongyu Zhao, Lin Yan, Weihua Jiang, Jung-Sun Kim, Bingnan Gu, Qipeng Liu, Rui Wang, Bo Xia, Jonathan C. Zhao, Gang Song, Wenyi Mi, Rong-Fu Wang, Xiaobing Shi, Hung-Ming Lam, Xuesen Dong, Jindan Yu, Kaifu Chen, Qi Cao
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
The polycomb group protein BMI1 is highly expressed in prostate cancer. Here, the authors demonstrate that BMI1 directly interacts with AR leading to increased AR signaling independently of PRC1 complex and that targeting BMI1 inhibits tumor growth o
Externí odkaz:
https://doaj.org/article/2c11102c772b403f8c968a42953aed26
CD95/Fas Increases Stemness in Cancer Cells by Inducing a STAT1-Dependent Type I Interferon Response
Autor:
Abdul S. Qadir, Paolo Ceppi, Sonia Brockway, Calvin Law, Liang Mu, Nikolai N. Khodarev, Jung Kim, Jonathan C. Zhao, William Putzbach, Andrea E. Murmann, Zhuo Chen, Wenjing Chen, Xia Liu, Arthur R. Salomon, Huiping Liu, Ralph R. Weichselbaum, Jindan Yu, Marcus E. Peter
Publikováno v:
Cell Reports, Vol 18, Iss 10, Pp 2373-2386 (2017)
Stimulation of CD95/Fas drives and maintains cancer stem cells (CSCs). We now report that this involves activation of signal transducer and activator of transcription 1 (STAT1) and induction of STAT1-regulated genes and that this process is inhibited
Externí odkaz:
https://doaj.org/article/d9d2c0eccc6c4397b26f9a483be369d9
Autor:
Jung Kim, Yongik Lee, Xiaodong Lu, Bing Song, Ka-Wing Fong, Qi Cao, Jonathan D. Licht, Jonathan C. Zhao, Jindan Yu
Publikováno v:
Cell Reports, Vol 25, Iss 10, Pp 2808-2820.e4 (2018)
Summary: Enhancer of Zeste 2 (EZH2) is the enzymatic subunit of Polycomb Repressive Complex 2 (PRC2), which catalyzes histone H3 lysine 27 trimethylation (H3K27me3) at target promoters for gene silencing. Here, we report that EZH2 activates androgen
Externí odkaz:
https://doaj.org/article/78b337d5085a4e5585aee922caaf67f5
Autor:
Ali Zhang, Jonathan C. Zhao, Jung Kim, Ka-wing Fong, Yeqing Angela Yang, Debabrata Chakravarti, Yin-Yuan Mo, Jindan Yu
Publikováno v:
Cell Reports, Vol 13, Iss 1, Pp 209-221 (2015)
Understanding the mechanisms of androgen receptor (AR) activation in the milieu of low androgen is critical to effective treatment of castration-resistant prostate cancer (CRPC). Here, we report HOTAIR as an androgen-repressed lncRNA, and, as such, i
Externí odkaz:
https://doaj.org/article/665f5d4981a44ca8949e0fc92853824b
Autor:
Zhuoyuan Lin, Shivani Agarwal, Song Tan, Hongshun Shi, Xiaodong Lu, Zhipeng Tao, Xuesen Dong, Xu Wu, Jonathan C. Zhao, Jindan Yu
Publikováno v:
Oncogene.
Autor:
Xiaodong Lu, Ka-wing Fong, Galina Gritsina, Fang Wang, Sylvan C. Baca, Lourdes T. Brea, Jacob E. Berchuck, Sandor Spisak, Jenny Ross, Colm Morrissey, Eva Corey, Navdeep S. Chandel, William J. Catalona, Ximing Yang, Matthew L. Freedman, Jonathan C. Zhao, Jindan Yu
Publikováno v:
Nature Genetics. 54:670-683
Autor:
Jindan Yu, Matthew B. Rettig, Colm Morrissey, Johann S. de Bono, Arul M. Chinnaiyan, Felix Y. Feng, Peter S. Nelson, Ximing J. Yang, Caterina Aversa, Wei Yuan, Adam Sharp, Jung Kim, Jonathan C. Zhao, Ali Zhang, Galina Gritsina, Ka-wing Fong, Shangze Li
Castration-resistant prostate cancer (CRPC) that has developed resistance to the new-generation androgen receptor (AR) antagonist enzalutamide is a lethal disease. Transcriptome analysis of multiple prostate cancer models identified CXCR7, an atypica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::459af5dfa447edf4b82779dd14f30984
https://doi.org/10.1158/0008-5472.c.6510177.v1
https://doi.org/10.1158/0008-5472.c.6510177.v1
Autor:
Jindan Yu, Matthew B. Rettig, Colm Morrissey, Johann S. de Bono, Arul M. Chinnaiyan, Felix Y. Feng, Peter S. Nelson, Ximing J. Yang, Caterina Aversa, Wei Yuan, Adam Sharp, Jung Kim, Jonathan C. Zhao, Ali Zhang, Galina Gritsina, Ka-wing Fong, Shangze Li
Supplementary Figure 1. Generation of Enz-resistant prostate cancer cell lines. Supplementary Figure 2. AR directly represses CXCR7 gene expression. Supplementary Figure 3. CXCR7 expression is required for C4-2B Enz-resistant prostate cancer cell sur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fb5973d954f6b1a084a51f7a330cb75
https://doi.org/10.1158/0008-5472.22418607
https://doi.org/10.1158/0008-5472.22418607