Výsledky vyhledávání - "Jonathan C. Walsh"

Regulation of macrophage and neutrophil cell fates by the PU.1:C/EBPα ratio and granulocyte colony-stimulating factor

Autor: M. Celeste Simon, Sangeeta R. Iyer, Peter Laslo, Jonathan C Walsh, David W. Lancki, Richard Dahl, Harinder Singh

Publikováno v: Nature Immunology. 4:1029-1036

Hematopoietic transcription factors are essential for specifying cell fates; however, the function of cytokines in such developmental decisions is unresolved. We demonstrate here that haploinsufficiency for the gene encoding the transcription factor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b240716370c6903fe96c7ffd9e90352
https://doi.org/10.1038/ni973

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Cooperative and Antagonistic Interplay between PU.1 and GATA-2 in the Specification of Myeloid Cell Fates

Autor: Daniel S. Friend, Michael F. Gurish, Richard L. Stevens, Harinder Singh, Rodney P. DeKoter, John Anastasi, Erica D. Smith, David W. Lancki, Hyun Jun Lee, Jonathan C Walsh

Publikováno v: Immunity. 17:665-676

PU.1 and GATA transcription factors appear to antagonize each other's function in the development of distinct lineages of the hematopoietic system. In contrast, we demonstrate that PU.1, like GATA-2, is essential for the generation of mast cells. PU.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac52a4797b7abd3b07a44ceafb38fea2
https://doi.org/10.1016/s1074-7613(02)00452-1

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PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors

Autor: Rodney P. DeKoter, Harinder Singh, Jonathan C Walsh

Publikováno v: The EMBO Journal. 17:4456-4468

PU.1 is a unique regulatory protein required for the generation of both the innate and the adaptive immune system. It functions exclusively in a cell-intrinsic manner to control the development of granulocytes, macrophages, and B and T lymphocytes. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afb3ba8c7897036e8b5b676ea3d0a25f
https://doi.org/10.1093/emboj/17.15.4456

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Human papillomavirus E6 and E7 oncoproteins alter cell cycle progression but not radiosensitivity of carcinoma cells treated with low-dose-rate radiation

Autor: William G. Nelson, Jonathan C. Walsh, Theodore L. DeWeese, Kathleen R. Cho, Larry E. Dillehay, Theodore D. Kessis, Lora Hedrick

Publikováno v: International Journal of Radiation Oncology*Biology*Physics. 37:145-154

Purpose: Low-dose-rate radiation therapy has been widely used in the treatment of urogenital malignancies. When continuously exposed to low-dose-rate ionizing radiation, target cancer cells typically exhibit abnormalities in replicative cell-cycle pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40ec0a1b7ea274dc3f761f952f9891b2
https://doi.org/10.1016/s0360-3016(96)00448-8

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PU.1, a shared transcriptional regulator of lymphoid and myeloid cell fates

Autor: Rodney P. DeKoter, Jonathan C Walsh, Harinder Singh

Publikováno v: Cold Spring Harbor symposia on quantitative biology. 64

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a709125c5de143dcba294735344a47f
https://pubmed.ncbi.nlm.nih.gov/11232277

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Androgen ablation-induced programmed death of prostatic glandular cells does not involve recruitment into a defective cell cycle or p53 induction

Autor: William G. Nelson, Jonathan C. Walsh, Xiaohui S. Lin, Yuzo Furuya, John T. Isaacs

Publikováno v: Endocrinology. 136(5)

Proliferating cells characteristically undergo programmed (i.e. apoptotic) death if their progression through the cell cycle is sufficiently perturbed. To determine whether androgen ablation-induced programmed death of prostatic glandular cells invol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c167ec6b56d3beec95dfa4029d8055a0
https://pubmed.ncbi.nlm.nih.gov/7720636

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Molecular Characterization of Defective Antigen Processing in Human Prostate Cancer

Autor: Yutaka Kawakami, Jonathan W. Simons, William G. Nelson, Nicholas P. Restifo, Martin G. Sanda, Jonathan C. Walsh, Drew M. Pardoll

Background Gene-modified tumor cell vaccines have shown efficacy in animal models of malignancy, including prostate cancer. Class I major histocompatibility complex (MHC) assembly and function in the cellular targets of such therapies is pivotal in d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::778939a490bdde63a6f24122d9e16a42
https://europepmc.org/articles/PMC2104544/

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158 Acute dose and low dose-rate irradiation of carcinoma cells expressing human papillomavirus E6 and E7 oncoproteins — The significance of p53, Rb and G1 arrest status

Autor: Jonathan C. Walsh, Theodore L. DeWeese, William G. Nelson, Theodore D. Kessis, Larry E. Dillehay, Yi Shao, Kathleen R. Cho

Publikováno v: International Journal of Radiation Oncology*Biology*Physics. 32:220

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1ac16a3e480f838779237c84db16f285
https://doi.org/10.1016/0360-3016(95)97821-h

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Estrogen Enhancement of Androgen-Induced Renal Growth in the Male Rat

Autor: Jonathan C. Walsh, Stephen Berry

Publikováno v: Journal of Urology. 137:159-162

17 beta-estradiol enhances dihydrotestosterone-induced growth of the castrate male rat kidney by increasing cell number, cell size and tissue water retention. No estrogen enhancement was observed in sex accessory tissues or other organs. This estroge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52f5af9341100f34e66adb9696cf905d
https://doi.org/10.1016/s0022-5347(17)43910-3

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