Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Jonathan C. M. Wan"'
Autor:
Jonathan C. M. Wan, Dennis Stephens, Lingqi Luo, James R. White, Caitlin M. Stewart, Benoît Rousseau, Dana W. Y. Tsui, Luis A. Diaz
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Detection of mutational signatures in cell-free DNA (cfDNA) is challenging due to low sequence coverage and low mutant allele fractions. Here, the authors identify mutational signatures in plasma whole genome sequencing of cancer patients and use mac
Externí odkaz:
https://doaj.org/article/0be4d40d73634081ab710d857edeeeba
Autor:
Matthew H. V. Byrne, James Ashcroft, Laith Alexander, Jonathan C. M. Wan, Anmol Arora, Megan E. L. Brown, Anna Harvey, Andrew Clelland, Nicholas Schindler, Cecilia Brassett, Rachel Allan, on behalf of the MedEd Collaborative
Publikováno v:
BMC Medical Education, Vol 21, Iss 1, Pp 1-7 (2021)
Abstract Background The coronavirus disease 2019 pandemic has led to global disruption of healthcare. Many students volunteered to provide clinical support. Volunteering to work in a clinical capacity was a unique medical education opportunity; howev
Externí odkaz:
https://doaj.org/article/8288a43103bc48a289e023fab9c56afd
Autor:
Christopher G. Smith, Tina Moser, Florent Mouliere, Johanna Field-Rayner, Matthew Eldridge, Anja L. Riediger, Dineika Chandrananda, Katrin Heider, Jonathan C. M. Wan, Anne Y. Warren, James Morris, Irena Hudecova, Wendy N. Cooper, Thomas J. Mitchell, Davina Gale, Andrea Ruiz-Valdepenas, Tobias Klatte, Stephan Ursprung, Evis Sala, Antony C. P. Riddick, Tevita F. Aho, James N. Armitage, Samantha Perakis, Martin Pichler, Maximilian Seles, Gabriel Wcislo, Sarah J. Welsh, Athena Matakidou, Tim Eisen, Charles E. Massie, Nitzan Rosenfeld, Ellen Heitzer, Grant D. Stewart
Publikováno v:
Genome Medicine, Vol 12, Iss 1, Pp 1-17 (2020)
Abstract Background Cell-free tumor-derived DNA (ctDNA) allows non-invasive monitoring of cancers, but its utility in renal cell cancer (RCC) has not been established. Methods Here, a combination of untargeted and targeted sequencing methods, applied
Externí odkaz:
https://doaj.org/article/2a2d59f651d64baaa2bf45b983922529
Autor:
Andrew B Gill, Leonardo Rundo, Jonathan C. M. Wan, Doreen Lau, Jeries P. Zawaideh, Ramona Woitek, Fulvio Zaccagna, Lucian Beer, Davina Gale, Evis Sala, Dominique-Laurent Couturier, Pippa G. Corrie, Nitzan Rosenfeld, Ferdia A. Gallagher
Publikováno v:
Cancers, Vol 12, Iss 12, p 3493 (2020)
Clinical imaging methods, such as computed tomography (CT), are used for routine tumor response monitoring. Imaging can also reveal intratumoral, intermetastatic, and interpatient heterogeneity, which can be quantified using radiomics. Circulating tu
Externí odkaz:
https://doaj.org/article/7635b90d886e451d8953af19feef04b9
Autor:
Megan E. L. Brown, Matthew H V Byrne, Jonathan C M Wan, Cecilia Brassett, Laith Alexander, James Ashcroft, Nicholas Schindler, Anna Harvey
Publikováno v:
Postgraduate Medical Journal.
Purpose Understanding the factors that influence prosocial behaviour during the COVID-19 pandemic is essential due to the disruption to healthcare provision. Methods We conducted an in-depth, mixed-methods cross-sectional survey, from 2 May 2020 to 1
Publikováno v:
Trends Cancer
Deeper and broader sequencing of circulating tumor DNA (ctDNA) has identified a wealth of cancer markers in the circulation, resulting in a paradigm shift towards data science-driven liquid biopsies in oncology. Although panel sequencing for actionab
Autor:
Jonathan C. M. Wan
Publikováno v:
Curr Urol
Background Studies report that survival outcomes in patients with non-muscle-invasive bladder cancer (NMIBC) are worse when cystectomy is delayed. However, no systematic evidence is available. Objective The aim of this study was to systematically rev
Autor:
Jonathan C. M. Wan, Dennis Stephens, Lingqi Luo, James R. White, Caitlin M. Stewart, Benoît Rousseau, Dana W. Y. Tsui, Luis A. Diaz
Publikováno v:
Nature communications. 13(1)
Mutational signatures accumulate in somatic cells as an admixture of endogenous and exogenous processes that occur during an individual’s lifetime. Since dividing cells release cell-free DNA (cfDNA) fragments into the circulation, we hypothesize th
Autor:
Jonathan C M Wan, N. Schindler, James Ashcroft, Anna Harvey, Megan E. L. Brown, Laith Alexander, Matthew H V Byrne, Cecilia Brassett
Publikováno v:
The British Journal of Surgery
Introduction Professional identity formation (PIF) is a priority of medical training. Covid-19 caused disruption to medical education. We ask how this disruption impacted PIF through the lens of the activities performed – or not performed – by me
Autor:
Benoit Rousseau, Luis A. Diaz, Guillem Argilés, Jonathan C M Wan, Justin Jee, Michael B. Foote, Melissa S. Pessin, James R. White
Publikováno v:
JAMA Oncol
Importance Novel therapies for SARS-CoV-2 infection are urgently needed. Antineoplastic compounds that target cellular machinery used by SARS-CoV-2 for entry and replication, including angiotensin-converting enzyme 2 (ACE2), may disrupt SARS-CoV-2 ac