Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jonathan C. K. Quirke"'
Autor:
David Crich, Jonathan C. K. Quirke
Publikováno v:
ACS Catal
Super-armed glycosyl donors, whose substituents are predominantly held in pseudoaxial positions, exhibit strongly increased reactivity in glycosylation through significant stabilization of oxocarbenium-like transition states. Examination of X-ray cry
Autor:
David Crich, Jonathan C. K. Quirke
Publikováno v:
J Am Chem Soc
Carbohydrate side chain conformation confers a significant influence on reactivity during glycosylation and anomeric bond hydrolysis due to stabilization of the oxocarbenium intermediate or oxocarbenium-like transition state. By analysis of 513 pyran
Autor:
Vikram A. Sarpe, Klara Haldimann, Jonathan C. K. Quirke, Parasuraman Rajasekaran, David Crich, Erik C. Böttger, Andrea Vasella, Marina Gysin, Dimitri Shcherbakov, Ivan Osinnii, Qiao-Jun Fang, Su-Hua Sha, Amr Sonousi, Jochen Schacht, Sven N. Hobbie
Publikováno v:
J Am Chem Soc
Apramycin is a structurally unique member of the 2-deoxystreptamine class of aminoglycoside antibiotics characterized by a monosubstituted 2-deoxystreptamine ring that carries an unusual bicyclic eight-carbon dialdose moiety. Because of its unusual s
Autor:
David Crich, Jonathan C. K. Quirke
Publikováno v:
ACS Catal
Carbohydrate side chain conformation is an important factor in the control of reactivity at the anomeric center, ie, in the making and breaking of glycosidic bonds, whether chemically or, for hydrolysis, by glycoside hydrolases. In nature glycosidic
Autor:
Prabuddha Waduge, David Crich, Amr Sonousi, Christine S. Chow, Erik C. Böttger, Su-Hua Sha, Andrea Vasella, Tanja Janusic, Klara Haldimann, Marina Gysin, Jonathan C. K. Quirke, Shan Xu, Jochen Schacht, Sven N. Hobbie
Publikováno v:
ChemMedChem
We describe the convergent synthesis of a 5-O-β-D-ribofuranosyl-based apramycin derivative (apralog) that displays significantly improved antibacterial activity over the parent apramycin against wild-type ESKAPE pathogens. In addition, the new apral