Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jonathan C. Grima"'
Autor:
Kathleen M Cunningham, Kirstin Maulding, Kai Ruan, Mumine Senturk, Jonathan C Grima, Hyun Sung, Zhongyuan Zuo, Helen Song, Junli Gao, Sandeep Dubey, Jeffrey D Rothstein, Ke Zhang, Hugo J Bellen, Thomas E Lloyd
Publikováno v:
eLife, Vol 9 (2020)
Disrupted nucleocytoplasmic transport (NCT) has been implicated in neurodegenerative disease pathogenesis; however, the mechanisms by which disrupted NCT causes neurodegeneration remain unclear. In a Drosophila screen, we identified ref(2)P/p62, a ke
Externí odkaz:
https://doaj.org/article/1a36dcfe2f884b73b4686aa681abb4ea
Author response: TFEB/Mitf links impaired nuclear import to autophagolysosomal dysfunction in C9-ALS
Autor:
Kai Ruan, Zhongyuan Zuo, Sandeep Dubey, Ke Zhang, Thomas E. Lloyd, Mumine Senturk, Helen Song, Hugo J. Bellen, Junli Gao, Hyun Sung, Jonathan C. Grima, Kirstin Maulding, Jeffrey D. Rothstein, Kathleen M. Cunningham
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::628c9af1fc3f51da73905796f2e4344e
https://doi.org/10.7554/elife.59419.sa2
https://doi.org/10.7554/elife.59419.sa2
Autor:
Hugo J. Bellen, Ke Zhang, Jeffrey D. Rothstein, Helen Song, Jonathan C. Grima, Kai Ruan, Kathleen M. Cunningham, Mumine Senturk, Zhongyuan Zuo, Hyun Sung, Kirstin Maulding, Thomas E. Lloyd
Disrupted nucleocytoplasmic transport (NCT) has been implicated in neurodegenerative disease pathogenesis; however, the mechanisms by which impaired NCT causes neurodegeneration remain unclear. In a Drosophila screen, we identified Ref(2)p/p62, a key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02f841ea349ec7d72590b29d0fe7c90d
https://doi.org/10.1101/2020.06.26.173021
https://doi.org/10.1101/2020.06.26.173021
Autor:
Byoung Dae Lee, Lorraine Iacovitti, Han Seok Ko, Jeannette N. Stankowski, Xiaobo Mao, Jonathan C. Grima, Yunjong Lee, Sung Ung Kang, Valina L. Dawson, Lino Tessarollo, Senthilkumar S. Karuppagounder, Deborah A. Swing, Stewart Neifert, Haisong Jiang, Ted M. Dawson, Yulan Xiong, Qinfang Liu
Publikováno v:
Proceedings of the National Academy of Sciences. 115:1635-1640
Mutations in LRRK2 are known to be the most common genetic cause of sporadic and familial Parkinson's disease (PD). Multiple lines of LRRK2 transgenic or knockin mice have been developed, yet none exhibit substantial dopamine (DA)-neuron degeneration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96c8a0b16ea773f7ed97d85bcc341dd6
https://doi.org/10.1073/pnas.1712648115
https://doi.org/10.1073/pnas.1712648115
Autor:
Soyeon Lim, Adrianne S Chesser, Jonathan C Grima, Phillip M Rappold, David Blum, Serge Przedborski, Kim Tieu
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24620 (2011)
Abnormalities in mitochondrial function and epigenetic regulation are thought to be instrumental in Huntington's disease (HD), a fatal genetic disorder caused by an expanded polyglutamine track in the protein huntingtin. Given the lack of effective t
Externí odkaz:
https://doaj.org/article/8488f6096848471e9ca9f2beab9c1e23
Autor:
Ya Fei Xu, Jeannie Chew, Jonathan C. Grima, Kevin B. Boylan, Amanda M. Liesinger, Wen Lang Lin, Chad A. Dickey, Guojun Bu, Christopher D. Link, Jennifer Gass, Yong Jie Zhang, Zizhao S. Wang, Aliesha Garrett, Emilie A. Perkerson, Jeremy D. Baker, Hiroki Sasaguri, Jeannette N. Stankowski, Mei Yue, Clotilde Lagier-Tourenne, Rebecca B. Katzman, Leonard Petrucelli, Jie Jiang, John D. Fryer, Tania F. Gendron, Karen Jansen-West, Monica Castanedes-Casey, Lillian M. Daughrity, Jimei Tong, Aishe Kurti, Dieter Edbauer, Dennis W. Dickson, Mitsuru Shinohara, Melissa E. Murray, Jeffrey D. Rothstein, Don W. Cleveland, Rosa Rademakers
Publikováno v:
Nature reviews / Neuroscience 19(5), 668-677 (2016). doi:10.1038/nn.4272
Nature neuroscience, vol 19, iss 5
Nature neuroscience
Nature neuroscience, vol 19, iss 5
Nature neuroscience
Neuronal inclusions of poly(GA), a protein unconventionally translated from G(4)C(2) repeat expansions in C9ORF72, are abundant in patients with frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) caused by this mutation. To investi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64c82cd0d13a2f06a3feaadec00965c0
https://doi.org/10.1038/nn.4272
https://doi.org/10.1038/nn.4272
Autor:
Casey Cook, Svetlana Vidensky, Rachel E. Bennett, Jeffrey D. Rothstein, Charles R. Vanderburg, Fred H. Gage, Michael DeTure, Susanne Wegmann, Roderick Y. H. Lim, Leonard Petrucelli, Bahareh Eftekharzadeh, Xavier Salvatella, Juan C. Troncoso, Jerome Mertens, Larisa E. Kapinos, Eckhard Mandelkow, Simon Dujardin, J. Gavin Daigle, Bianca T. Corjuc, Jose J. Gonzalez, Yari Carlomagno, Alyssa N. Coyne, Sean J. Miller, Bradley T. Hyman, Ana S. Amaral, Jonathan C. Grima, Katharina Tepper, Jeannie Chew, Julia Schiantarelli, Sarah L. DeVos
Publikováno v:
Neuron 99(5), 925-940.e7 (2018). doi:10.1016/j.neuron.2018.07.039
Summary Tau is the major constituent of neurofibrillary tangles in Alzheimer’s disease (AD), but the mechanism underlying tau-associated neural damage remains unclear. Here, we show that tau can directly interact with nucleoporins of the nuclear po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e840905c53dddd18d9210e43dc2063b5
https://europepmc.org/articles/PMC6240334/
https://europepmc.org/articles/PMC6240334/
Autor:
Bradley T. Hyman, J. Gavin Daigle, Nicholas J. Valle, Rachel E. Bennett, Sarah L. DeVos, Svetlana Vidensky, Ana C. Amaral, Casey Cook, Jeffrey D. Rothstein, Caitlin Commins, Xavier Salvatella, Danny MacKenzie, Eckhard Mandelkow, Roderick Y. H. Lim, Susanne Wegmann, Larisa E. Kapinos, Juan C. Troncoso, Jerome Mertens, Sean J. Miller, Julia Schiantarelli, Jonathan C. Grima, Bahareh Eftekharzadeh, Fred H. Gage, Katharina Tepper, Charles R. Vanderburgh, Leonard Petrucelli, Alyssa N. Coyne, Bianca T. Corjuc, Uzma Hussain, Jose J. Gonzalez, Yari Carlomagno, Masato Maesako, Simon Dujardin
Publikováno v:
SSRN Electronic Journal.
Tau protein, which normally functions to stabilize microtubules, is the major constituent of neurofibrillary tangles in Alzheimer’s disease (AD). The mechanism underlying tau-associated neural damage remains unclear. We now show that tau can intera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bbb03579de4710a4b06e34855174b49
https://doi.org/10.2139/ssrn.3155576
https://doi.org/10.2139/ssrn.3155576
Publikováno v:
Neurodegenerative Disease Management. 4:417-437
SUMMARY Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive motor neuron degeneration. The disease pathogenesis is multifaceted in that multiple cellular and molecular pathways have been identified a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::663fe9ace73a9149357c3a6d4cb902c7
https://doi.org/10.2217/nmt.14.36
https://doi.org/10.2217/nmt.14.36
A GGGGCC hexanucleotide repeat expansion in C9orf72 is the most common genetic cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Recent studies indicate that disruption of nucleocytoplasmic transport pathways pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58cd7854ca24504c71c1a55ef996b148
https://europepmc.org/articles/PMC4916865/
https://europepmc.org/articles/PMC4916865/