Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Jonathan C. Choy"'
Autor:
Jason R. Nesbitt, Elizabeth Y. Steves, Cole R. Schonhofer, Alissa Cait, Sukhbir S. Manku, Juliana H. F. Yeung, Andrew J. Bennet, Kelly M. McNagny, Jonathan C. Choy, Michael R. Hughes, Margo M. Moore
Publikováno v:
Frontiers in Microbiology, Vol 8 (2018)
Aspergillus fumigatus is a filamentous fungus that can cause a life-threatening invasive pulmonary aspergillosis (IPA) in immunocompromised individuals. We previously characterized an exo-sialidase from A. fumigatus that prefers the sialic acid subst
Externí odkaz:
https://doaj.org/article/34ae0cdcb89646779bdc15f44696a7bc
Autor:
Kevin M. Rey, Franklin F. Tam, Winnie Enns, Javaria F. Rahim, Kwestan Safari, Elizabeth Guinto, Thea Van Rossum, Fiona S.L. Brinkman, Jonathan C. Choy
Publikováno v:
Transplantation. 106:2155-2165
The gut microbiota affects immune responses that cause organ transplant rejection, but the mechanisms by which this occurs remain poorly understood.We have examined, in a murine model, how disruption of the gut microbiota with antibiotics early in li
Autor:
Caigan Du, Haiming D. Luo, Megan K. Levings, Christine M. Wardell, Kevin Rey, Jayachandran N. Kizhakkedathu, Lyann Sim, Jonathan C. Choy, Qiunong Guan, Stephen G. Withers, Zheng J. Zhang, Franklin Tam, Mahdis Monajemi, Haisle Moon, Majid Mojibian, Ashani Montgomery, Erika M. J. Siren, Winnie Enns, Jiao Jing Wang
Publikováno v:
Nature Biomedical Engineering. 5:1202-1216
Systemic immunosuppression for the mitigation of immune rejection after organ transplantation causes adverse side effects and constrains the long-term benefits of the transplanted graft. Here we show that protecting the endothelial glycocalyx in vasc
Autor:
Chris Gursche, Ashani Montgomery, Franklin Tam, Catherine Cheneval, Sukhkbir Manku, Katrina Besler, Bruce M. McManus, Paul J. Hanson, Jonathan C. Choy, Kevin Rey, Winnie Enns, Stefan Rose-John
Publikováno v:
American Journal of Physiology-Cell Physiology. 320:C554-C565
IL-6 affects tissue protective/reparative and inflammatory properties of vascular endothelial cells (ECs). This cytokine can signal to cells through classic and trans-signaling mechanisms, which are differentiated based on the expression of IL-6 rece
Autor:
Daniel Luo, Erika MJ Siren, Winnie Enns, Lyann Sim, Franklin Tam, Javairia Rahim, Caigan Du, Dicken Ko, Steve Withers, Jonathan C Choy, Jayachandran N Kizhakkedathu
Publikováno v:
Transplantation. 106:S486-S487
Publikováno v:
Canadian Journal of Chemistry. 97:737-744
The antibody bioarray is a promising tool for the detection of proteins, which can be used as disease biomarkers. Therefore, we have developed a sandwich immunoassay-type bioarray using a microfluidic method to detect human interleukins that have dia
Publikováno v:
Frontiers in Immunology, Vol 5 (2015)
Solid organ transplantation is the only treatment for end-stage organ failure but this life-saving procedure is limited by immune-mediated rejection of most grafts. Blood vessels within transplanted organs are targeted by the immune system and the re
Externí odkaz:
https://doaj.org/article/47ce6dcd0d7a4a748df6ca94319e8a9c
Autor:
Kevin Rey, Jonathan C. Choy
Publikováno v:
Clinics in Laboratory Medicine. 39:185-195
The microbiota is a community of microbes that colonizes body surfaces. It has many effects that influence immune activation and regulation. The success of organ transplantation is limited by rejection of grafts by the immune system so it is importan
Autor:
Erika M J, Siren, Haiming D, Luo, Franklin, Tam, Ashani, Montgomery, Winnie, Enns, Haisle, Moon, Lyann, Sim, Kevin, Rey, Qiunong, Guan, Jiao-Jing, Wang, Christine M, Wardell, Mahdis, Monajemi, Majid, Mojibian, Megan K, Levings, Zheng J, Zhang, Caigan, Du, Stephen G, Withers, Jonathan C, Choy, Jayachandran N, Kizhakkedathu
Publikováno v:
Nature biomedical engineering. 5(10)
Systemic immunosuppression for the mitigation of immune rejection after organ transplantation causes adverse side effects and constrains the long-term benefits of the transplanted graft. Here we show that protecting the endothelial glycocalyx in vasc
Autor:
Kamran Shojania, J Antonio Aviña-Zubieta, Kevin Rey, Zongshu Luo, Winnie Enns, Michael A. Seidman, Sukhbir Manku, Jonathan C. Choy, Wendy Wong, Zainab Alabdurubalnabi
Publikováno v:
Cardiovascular Pathology. 33:55-61
Giant cell arteritis (GCA) is the most common vasculitis in adults affecting large and medium-sized arteries. IL-6 and T cell accumulation within the arterial wall contribute to the pathogenesis of GCA, and blockade of IL-6 activity is efficacious in