Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Jonathan C Morris"'
Autor:
Martin Wohlwend, Pirkka-Pekka Laurila, Ludger JE Goeminne, Tanes Imamura de lima, Ioanna Daskalaki, Xiaoxu Li, Giacomo von Alvensleben, Barbara Crisol, Renata Mangione, Hector Gallart-Ayala, Amelia Lalou, Olivier Burri, Stephen Butler, Jonathan C Morris, Nigel Turner, Julijana Ivanisevic, Johan Auwerx
Publikováno v:
eLife, Vol 13 (2024)
Externí odkaz:
https://doaj.org/article/c54b2c68b1ee4416b63703caea4ade82
Autor:
Alexis Diaz-Vegas, Søren Madsen, Kristen C Cooke, Luke Carroll, Jasmine XY Khor, Nigel Turner, Xin Y Lim, Miro A Astore, Jonathan C Morris, Anthony S Don, Amanda Garfield, Simona Zarini, Karin A Zemski Berry, Andrew P Ryan, Bryan C Bergman, Joseph T Brozinick, David E James, James G Burchfield
Publikováno v:
eLife, Vol 12 (2023)
Insulin resistance (IR) is a complex metabolic disorder that underlies several human diseases, including type 2 diabetes and cardiovascular disease. Despite extensive research, the precise mechanisms underlying IR development remain poorly understood
Externí odkaz:
https://doaj.org/article/d4808a63f21b4fbe996fd89139b71d2a
Autor:
Prema M Nair, Malcolm R Starkey, Tatt Jhong Haw, Gang Liu, Adam M Collison, Joerg Mattes, Peter A. Wark, Jonathan C Morris, Nikki M Verrills, Andrew R Clark, Alaina J Ammit, Philip M Hansbro
Publikováno v:
Clinical & Translational Immunology, Vol 8, Iss 10, Pp n/a-n/a (2019)
Abstract Objective Chronic obstructive pulmonary disease (COPD) is a progressive disease that causes significant mortality and morbidity worldwide and is primarily caused by the inhalation of cigarette smoke (CS). Lack of effective treatments for COP
Externí odkaz:
https://doaj.org/article/3f9da2127a404b8dbf99a5f36fff84a6
Autor:
Adam M. Collison, Junyao Li, Ana Pereira de Siqueira, Xuejiao Lv, Hamish D. Toop, Jonathan C. Morris, Malcolm R. Starkey, Philip M. Hansbro, Jie Zhang, Joerg Mattes
Publikováno v:
BMC Pulmonary Medicine, Vol 19, Iss 1, Pp 1-11 (2019)
Abstract Background Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) has previously been demonstrated to play a pro-inflammatory role in allergic airways disease and COPD through the upregulation of the E3 ubiquitin ligase MID1 and th
Externí odkaz:
https://doaj.org/article/771e16d3156042ba8c13a861f27d74e7
Autor:
Naseeb K. Malhi, Claire L. Allen, Elizabeth Stewart, Katherine L. Horton, Federica Riu, Jennifer Batson, Winfried Amoaku, Jonathan C. Morris, Kenton P. Arkill, David O. Bates
Publikováno v:
Am J Physiol Heart Circ Physiol
Angiogenic VEGF isoforms are upregulated in diabetic retinopathy (DR), driving pathological growth and fluid leakage. Serine-arginine-rich protein kinase-1 (SRPK1) regulates VEGF splicing, and its inhibition blocks angiogenesis. We tested the hypothe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92c7ba6a15b0ed5f4f00829d0ffad211
https://doi.org/10.1152/ajpheart.00001.2022
https://doi.org/10.1152/ajpheart.00001.2022
Autor:
Laurent Meijer, Vicente Notario, Jane A. Endicott, Aude Echalier, Benoît Joseph, Bernard Marquet, François Liger, Michael H.G. Kubbutat, Christoph Schächtele, Peter Drueckes, Silvia Mateo-Lozano, Jonathan C. Morris, Olivier Lozach, Yoan Ferandin, Séverine Marionneau-Lambot, Oscar M. Tirado, Karima Bettayeb
Protein kinases represent promising anticancer drug targets. We describe here the meriolins, a new family of inhibitors of cyclin-dependent kinases (CDK). Meriolins represent a chemical structural hybrid between meridianins and variolins, two familie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::862a2f4d144630c783bf14488d81f62d
https://doi.org/10.1158/0008-5472.c.6495774.v1
https://doi.org/10.1158/0008-5472.c.6495774.v1
Autor:
Laurent Meijer, Vicente Notario, Jane A. Endicott, Aude Echalier, Benoît Joseph, Bernard Marquet, François Liger, Michael H.G. Kubbutat, Christoph Schächtele, Peter Drueckes, Silvia Mateo-Lozano, Jonathan C. Morris, Olivier Lozach, Yoan Ferandin, Séverine Marionneau-Lambot, Oscar M. Tirado, Karima Bettayeb
Supplementary Figure 4 from Meriolins, a New Class of Cell Death–Inducing Kinase Inhibitors with Enhanced Selectivity for Cyclin-Dependent Kinases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be3970f1381a1112fc3eac3f8d94c493
https://doi.org/10.1158/0008-5472.22368006
https://doi.org/10.1158/0008-5472.22368006
Autor:
Laurent Meijer, Vicente Notario, Jane A. Endicott, Aude Echalier, Benoît Joseph, Bernard Marquet, François Liger, Michael H.G. Kubbutat, Christoph Schächtele, Peter Drueckes, Silvia Mateo-Lozano, Jonathan C. Morris, Olivier Lozach, Yoan Ferandin, Séverine Marionneau-Lambot, Oscar M. Tirado, Karima Bettayeb
Methods and Materials, Figure 4 Legend from Meriolins, a New Class of Cell Death–Inducing Kinase Inhibitors with Enhanced Selectivity for Cyclin-Dependent Kinases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::518409c14552a25e83b2c37283b71aa5
https://doi.org/10.1158/0008-5472.22368009
https://doi.org/10.1158/0008-5472.22368009
Autor:
Hubert Hondermarck, Frank Alvaro, Zacary P. Germon, Heather C. Murray, Dominik Beck, Abdul Mannan, Charles E. de Bock, Stephen M. Butler, David A. Skerrett-Byrne, Hayley Flanagan, Matthew D. Dun, Patrick Connerty, Geoff De Iuliis, Jonathan C. Morris, Mengna Chi, Juhura G. Almazi, Hamish D. Toop, Brett Nixon, Ryan J. Duchatel, Sam Faulkner, Janis Chamberlain, Anoop K Enjeti, Callum J Rigby, Richard G. S. Kahl, Jonathan R. Sillar, Nicole M. Verrills
Publikováno v:
Leukemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecf25e7996c11ee55b060a0fd5704258
https://doi.org/10.1038/s41375-020-0814-0
https://doi.org/10.1038/s41375-020-0814-0
Autor:
Martin D. Rees, Jonathan C. Morris, Shane R. Thomas, Tom Hawtrey, Irene De Silvestro, Jacqueline Ku, Ernst Malle, Sophie Maiocchi
Publikováno v:
Chemical research in toxicology. 34(6)
The heme enzyme myeloperoxidase (MPO) is a key mediator of endothelial dysfunction and a therapeutic target in cardiovascular disease. During inflammation, MPO released by circulating leukocytes is internalized by endothelial cells and transcytosed i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2185e67d7b59e1a4a1ff62680469feb4
https://pubmed.ncbi.nlm.nih.gov/34085520
https://pubmed.ncbi.nlm.nih.gov/34085520