Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Jonathan C Kagan"'
Autor:
Jazlyn P Borges, Ragnhild SR Sætra, Allen Volchuk, Marit Bugge, Pascal Devant, Bjørnar Sporsheim, Bridget R Kilburn, Charles L Evavold, Jonathan C Kagan, Neil M Goldenberg, Trude Helen Flo, Benjamin Ethan Steinberg
Publikováno v:
eLife, Vol 11 (2022)
First recognized more than 30 years ago, glycine protects cells against rupture from diverse types of injury. This robust and widely observed effect has been speculated to target a late downstream process common to multiple modes of tissue injury. Th
Externí odkaz:
https://doaj.org/article/b409c84bf89f42e78ba1c725fcae156d
Autor:
Katherine C Barnett, Jonathan C Kagan
Publikováno v:
Innate Immunity, Vol 26 (2020)
Pattern Recognition Receptors (PRRs) detect evidence of infection and tissue damage. The activation of these receptors and their downstream signal transduction pathways initiate a protective immune response. These signaling pathways are influenced by
Externí odkaz:
https://doaj.org/article/b79bde8e5a8e429c8551518b56b41729
Autor:
Richard L Guerrant, Alvaro M Leite, Relana Pinkerton, Pedro H Q S Medeiros, Paloma A Cavalcante, Mark DeBoer, Margaret Kosek, Christopher Duggan, Andrew Gewirtz, Jonathan C Kagan, Anna E Gauthier, Jonathan Swann, Jordi Mayneris-Perxachs, David T Bolick, Elizabeth A Maier, Marjorie M Guedes, Sean R Moore, William A Petri, Alexandre Havt, Ila F Lima, Mara de Moura Gondim Prata, Josyf C Michaleckyj, Rebecca J Scharf, Craig Sturgeon, Alessio Fasano, Aldo A M Lima
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0158772 (2016)
Critical to the design and assessment of interventions for enteropathy and its developmental consequences in children living in impoverished conditions are non-invasive biomarkers that can detect intestinal damage and predict its effects on growth an
Externí odkaz:
https://doaj.org/article/ef20d7da711044f0ac7b01a43a096543
Autor:
Dania Zhivaki, Emily A. Gosselin, Debrup Sengupta, Holly Concepcion, Chisom Arinze, Jonathan Chow, Anastasia Nikiforov, Veronica Komoroski, Carolyn MacFarlane, Caitlin Sullivan, Jonathan C. Kagan
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTLipid nanoparticle (LNP)-encapsulated mRNAs have emerged as effective vaccination tools to stimulate immunity. The most common application of this technology is to deliver mRNAs that encode antigenic proteins to dendritic cells (DCs), which t
Externí odkaz:
https://doaj.org/article/7cb93058634644f4bf4573f58eef6538
Publikováno v:
Open Biology, Vol 12, Iss 10 (2022)
Since the publication of the Janeway's Pattern Recognition hypothesis in 1989, study of pathogen-associated molecular patterns (PAMPs) and their immuno-stimulatory activities has accelerated. Most studies in this area have been conducted in model org
Externí odkaz:
https://doaj.org/article/6f8e11f8f8394225af2a481f7cda3f2f
Autor:
Ana Rita Ferreira, Ana Gouveia, Ana Cristina Magalhães, Isabel Valença, Mariana Marques, Jonathan C. Kagan, Daniela Ribeiro
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Upon intracellular recognition of viral RNA, RIG-I-like proteins interact with MAVS at peroxisomes and mitochondria, inducing its oligomerization and the downstream production of direct antiviral effectors. The human cytomegalovirus (HCMV) is able to
Externí odkaz:
https://doaj.org/article/19738f301aca443bbae96b3fc66fe362
Autor:
Jonathan C. Kagan, Ellen V. Rothenberg, Arthur Weiss, Alexander Y. Rudensky, Stephen T. Smale
Publikováno v:
Trends in Immunology. 44:248-255
Autor:
Jonathan C. Kagan
Publikováno v:
Science. 379:333-335
Unsuccessful pathogenic activities may be key to activating host defenses to infection
Autor:
Gang Du, Liam B. Healy, Liron David, Caitlin Walker, Pietro Fontana, Ying Dong, Pascal Devant, Robbins Puthenveetil, Scott B. Ficarro, Anirban Banerjee, Jonathan C. Kagan, Judy Lieberman, Hao Wu
Publikováno v:
bioRxiv
Gasdermin D (GSDMD) is the common effector for cytokine secretion and pyroptosis downstream of inflammasome activation by forming large transmembrane pores upon cleavage by inflammatory caspases. Here we report the surprising finding that GSDMD cleav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3637370b9e56537d4294b3a6ab12486a
https://doi.org/10.1101/2023.03.07.531538
https://doi.org/10.1101/2023.03.07.531538
Autor:
Kenta Mosallanejad, Stephanie N. Kennedy, Kristin M. Bahleda, Kailey M. Slavik, Wen Zhou, Apurva A. Govande, Dustin C. Hancks, Philip J. Kranzusch, Jonathan C. Kagan
Publikováno v:
Science Immunology. 8
The mechanisms by which innate immune receptors mediate self-nonself discrimination are unclear. In this study, we found species-specific molecular determinants of self-DNA reactivity by cyclic guanosine monophosphate–adenosine monophosphate (GMP