Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jonathan C Jeschke"'
Autor:
Rebecca S. LaRue, Louisa E. Sjaastad, Mark S. Anderson, Calvin B. Williams, Praful Aggarwal, Maria-Luisa Alegre, Ulrich Broeckel, Shawn A. Mahmud, Irina Proekt, Dimitre R. Simeonov, Jason B. Williams, Michael A. Farrar, Weishan Huang, Jonathan C. Jeschke, Corey N. Miller, Roland Ruscher, David L. Owen, Christine Henzler, Justin A. Spanier, Can Hekim, Avery August, Alexander Marson, Ye Zheng
Publikováno v:
Nature immunology
The developmental programs that generate a broad repertoire of regulatory T cells (Treg cells) able to respond to both self antigens and non-self antigens remain unclear. Here we found that mature Treg cells were generated through two distinct develo
Autor:
Suresh Kumar, Nita H. Salzman, Jonathan C. Jeschke, Calvin B. Williams, Mariko Suchi, Selina Singh, Christopher L. Deciantis, William R. Drobyski, Jennifer Ziegelbauer, Christopher G. Mayne, Yoichiro Iwakura
Homeostasis in the ileum, which is commonly disrupted in patients with Crohn’s disease, involves ongoing immune responses. To study how homeostatic processes of the ileum impact CD4(+)T cell responses, we used TCR transgenic tools to breed mice tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d72767d4cf53a4031e1e745899c4a7ba
https://europepmc.org/articles/PMC6571016/
https://europepmc.org/articles/PMC6571016/
Publikováno v:
Journal of Leukocyte Biology. 100:1-3
Discussion of the relationship between human Treg potency and inhibition of TCR signaling in Teff cells.
Autor:
Christopher L De Ciantis, Jonathan C Jeschke, Matthew A Hadiono, Jennifer Ziegelbauer, Selina Singh, Mariko Suchi, Nita H Salzman, Calvin B Williams
Publikováno v:
The Journal of Immunology. 202:192.21-192.21
A spontaneous model of ileocolitis, a condition found in a majority of cases of Crohn’s Disease, allows for the study of processes that promote homeostasis within the ileum. Our system uses a “Bigenic” approach that combines TCR transgene mice
Publikováno v:
Journal of Leukocyte Biology. 97:623-625
Discussion on enhancers from the Cd8 locus and their ability to drive transgenic reporter expression in different types of CD8+ cells.
Autor:
Darin L. Wiesner, Jonathan C. Jeschke, Irina Vlasova-St. Louis, Bernd Rattenbacher, Daniel Beisang, Paul R. Bohjanen, Maximilian von Hohenberg
CUG-repeat binding protein 1 (CUGBP1) mediates selective mRNA decay by binding to GU-rich elements (GREs) containing the sequence UGUUUGUUUGU found in the 3' untranslated region (UTR) of short-lived transcripts. We used an anti-CUGBP1 antibody to imm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d6247e7369a8bbe7dc45736c557b58b
https://europepmc.org/articles/PMC4751690/
https://europepmc.org/articles/PMC4751690/
Autor:
Christopher L. De Ciantis, Jonathan C. Jeschke, Christopher G. Mayne, Jennifer Ziegelbauer, Selena Singh, Mariko Suchi, Yoichiro Iwakura, William R. Drobyski, Nita H. Salzman, Calvin B. Williams
Publikováno v:
The Journal of Immunology. 200:172.9-172.9
Crohn’s Disease is characterized by dysregulation of the immune response in the ileum. To study the perturbation of homeostasis within the ileum we utilize a “Bigenic” mouse model combining a TCR transgene and matching transgenic target antigen
Autor:
Jonathan C. Jeschke, Christopher G. Mayne, Christopher L. DeCiantis, Suresh N. Kumar, William R. Drobyski, Nita H. Salzman, Calvin B. Williams
Publikováno v:
The Journal of Immunology. 200:118.19-118.19
Homeostasis in the ileum involves ongoing immune responses. To study how homeostatic processes of the ileum impact CD4+T cell responses, we used TCR transgenic tools to breed “Bigenic” mice that spontaneously produced CD4+T cells reactive to a mo
Autor:
David L. Owen, Shawn A Mahmud, Jason B Williams, Jonathan C Jeschke, Praful Aggarwal, Ulrich Broeckel, Marisa Alegre, Ye Zheng, Calvin B Williams, Michael A Farrar
Publikováno v:
The Journal of Immunology. 198:215.15-215.15
Mature thymic regulatory T cells (Tregs) are defined by dual expression of Foxp3 and CD25 on CD4SP thymocytes. However, the cellular pathways by which CD4 thymocytes differentiate into Tregs remain incompletely understood. Previous reports demonstrat
Autor:
Erica G. Schmitt, Nita H. Salzman, Calvin B. Williams, Ke Yan, Dominic O. Co, Pippa Simpson, Manoj K. Mishra, Jennifer Ziegelbauer, Yoichiro Iwakura, Jonathan C. Jeschke, Dipica Haribhai
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 191(11)
To study regulatory T (Treg) cell control of chronic autoimmunity in a lymphoreplete host, we created and characterized a new model of autoimmune lung inflammation that targets the medium and small airways. We generated transgenic mice that express a