Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Jonathan C Brown"'
Autor:
Christine T Styles, Jie Zhou, Katie E Flight, Jonathan C Brown, Charlotte Lewis, Xinyu Wang, Michael Vanden Oever, Thomas P Peacock, Ziyin Wang, Rosie Millns, John S O’Neill, Alexander Borodavka, Joe Grove, Wendy S Barclay, John S Tregoning, Rachel S Edgar
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 7, Pp 1751-1751 (2024)
Externí odkaz:
https://doaj.org/article/f4a74545bc594cc4bcccd449114fd4d7
Autor:
Christine T Styles, Jie Zhou, Katie E Flight, Jonathan C Brown, Charlotte Lewis, Xinyu Wang, Michael Vanden Oever, Thomas P Peacock, Ziyin Wang, Rosie Millns, John S O'Neill, Alexander Borodavka, Joe Grove, Wendy S Barclay, John S Tregoning, Rachel S Edgar
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 12, Pp n/a-n/a (2023)
Abstract Viruses are vulnerable as they transmit between hosts, and we aimed to exploit this critical window. We found that the ubiquitous, safe, inexpensive and biodegradable small molecule propylene glycol (PG) has robust virucidal activity. Propyl
Externí odkaz:
https://doaj.org/article/81c9583b032d41f389c366a3cc12589e
Autor:
Gavin R Meehan, Vanessa Herder, Jay Allan, Xinyi Huang, Karen Kerr, Diogo Correa Mendonca, Georgios Ilia, Derek W Wright, Kyriaki Nomikou, Quan Gu, Sergi Molina Arias, Florian Hansmann, Alexandros Hardas, Charalampos Attipa, Giuditta De Lorenzo, Vanessa Cowton, Nicole Upfold, Natasha Palmalux, Jonathan C Brown, Wendy S Barclay, Ana Da Silva Filipe, Wilhelm Furnon, Arvind H Patel, Massimo Palmarini
Publikováno v:
PLoS Pathogens, Vol 19, Iss 11, p e1011589 (2023)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has continued to evolve throughout the coronavirus disease-19 (COVID-19) pandemic, giving rise to multiple variants of concern (VOCs) with different biological properties. As the pandemic p
Externí odkaz:
https://doaj.org/article/a36ebe930d79496085f27eaa475ecb69
Autor:
Helen Ward, Graham S. Cooke, Christina Atchison, Matthew Whitaker, Joshua Elliott, Maya Moshe, Jonathan C Brown, Barnaby Flower, Anna Daunt, Kylie Ainslie, Deborah Ashby, Christl A. Donnelly, Steven Riley, Ara Darzi, Wendy Barclay, Paul Elliott
Publikováno v:
The Lancet Regional Health. Europe, Vol 4, Iss , Pp 100098- (2021)
Background: The time-concentrated nature of the first wave of the COVID-19 epidemic in England in March and April 2020 provides a natural experiment to measure changes in antibody positivity at the population level before onset of the second wave and
Externí odkaz:
https://doaj.org/article/6e580c1a0f36497296c1cf18dbda8dc3
Autor:
Andreia L. Pinto, Ranjit K. Rai, Jonathan C. Brown, Paul Griffin, James R. Edgar, Anand Shah, Aran Singanayagam, Claire Hogg, Wendy S. Barclay, Clare E. Futter, Thomas Burgoyne
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Human airway epithelium infected with SARS-CoV-2 shows viral entry occurring at the apical plasma membrane, excluding cilia. Here, the visualization of viral fusion at the cell surface and budding profiles within infected cells through high-resolutio
Externí odkaz:
https://doaj.org/article/9ee1253d2c7b4498a8579b84171ef314
Autor:
Jie Zhou, Thomas P. Peacock, Jonathan C. Brown, Daniel H. Goldhill, Ahmed M.E. Elrefaey, Rebekah Penrice-Randal, Vanessa M. Cowton, Giuditta De Lorenzo, Wilhelm Furnon, William T. Harvey, Ruthiran Kugathasan, Rebecca Frise, Laury Baillon, Ria Lassaunière, Nazia Thakur, Giulia Gallo, Hannah Goldswain, I'ah Donovan-Banfield, Xiaofeng Dong, Nadine P. Randle, Fiachra Sweeney, Martha C. Glynn, Jessica L. Quantrill, Paul F. McKay, Arvind H. Patel, Massimo Palmarini, Julian A. Hiscox, Dalan Bailey, Wendy S. Barclay
Publikováno v:
Cell Reports, Vol 38, Iss 6, Pp 110344- (2022)
Summary: SARS-CoV-2 has a broad mammalian species tropism infecting humans, cats, dogs, and farmed mink. Since the start of the 2019 pandemic, several reverse zoonotic outbreaks of SARS-CoV-2 have occurred in mink, one of which reinfected humans and
Externí odkaz:
https://doaj.org/article/5920f150f705433295120a0e88ab3f2b
Autor:
Paul F. McKay, Kai Hu, Anna K. Blakney, Karnyart Samnuan, Jonathan C. Brown, Rebecca Penn, Jie Zhou, Clément R. Bouton, Paul Rogers, Krunal Polra, Paulo J. C. Lin, Christopher Barbosa, Ying K. Tam, Wendy S. Barclay, Robin J. Shattock
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
Here, the authors develop a self-amplifying RNA encoding the SARS-CoV-2 spike protein encapsulated within a lipid nanoparticle as a vaccine candidate and show induction of neutralization antibody titers in mice that are comparable to titers in conval
Externí odkaz:
https://doaj.org/article/d121c83855b64dc7847d5eded42ee84e
Autor:
Jonathan C. Brown, Alan Knight
Mexico's petroleum industry has come to symbolize the very sovereignty of the nation itself. Politicians criticize Pemex, the national oil company, at their peril, and President Salinas de Gortari has made clear that the free trade negotiations betwe
Formulation, inflammation, and RNA sensing impact the immunogenicity of self-amplifying RNA vaccines
Autor:
John S. Tregoning, David C. Stirling, Ziyin Wang, Katie E. Flight, Jonathan C. Brown, Anna K. Blakney, Paul F. McKay, Robert F. Cunliffe, Valarmathy Murugaiah, Christopher B. Fox, Mitchell Beattie, Ying K. Tam, Cecilia Johansson, Robin J. Shattock
Publikováno v:
Molecular Therapy - Nucleic Acids. 31:29-42
To be effective, RNA vaccines require both in situ translation and the induction of an immune response to recruit cells to the site of immunization. These factors can pull in opposite directions with the inflammation reducing expression of the vaccin
Autor:
Rebecca Frise, Laury Baillon, Jie Zhou, Ruthiran Kugathasan, Thomas P. Peacock, Jonathan C. Brown, Karnyart Samnuan, Paul F. McKay, Robin J. Shattock, Wendy S. Barclay
Publikováno v:
Vaccine. 40:2848-2855
Vaccines for SARS-CoV-2 have been hugely successful in alleviating hospitalization and deaths caused by the newly emerged coronavirus that is the cause of COVID. However, although the parentally administered vaccines are very effective at reducing se