Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Jonathan Brouillette"'
Autor:
Audrey Hector, Chloé Provost, Benoît Delignat-Lavaud, Khadija Bouamira, Chahinez-Anissa Menaouar, Valérie Mongrain, Jonathan Brouillette
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-14 (2023)
Abstract Background Soluble amyloid-beta oligomers (Aβo) begin to accumulate in the human brain one to two decades before a clinical diagnosis of Alzheimer’s disease (AD). The literature supports that soluble Aβo are implicated in synapse and neu
Externí odkaz:
https://doaj.org/article/2f6417eed4e74d12ba15182bc635bb6b
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Propagation of tau fibrils correlate closely with neurodegeneration and memory deficits seen during the progression of Alzheimer’s disease (AD). Although it is not well-established what drives or attenuates tau spreading, new studies on human brain
Externí odkaz:
https://doaj.org/article/a821ef0137e84c189c4d9cac348b019c
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
The role of non-neuronal cells has been relatively overlooked in Alzheimer’s disease (AD) neuropathogenesis compared to neuronal cells since the first characterization of the disease. Genome wide-association studies (GWAS) performed in the last few
Externí odkaz:
https://doaj.org/article/587c1e5255cf4f30a844cbd792ec8f74
Autor:
Audrey Hector, Jonathan Brouillette
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2021)
Soluble amyloid-beta oligomers (Aβo) start to accumulate in the human brain one to two decades before any clinical symptoms of Alzheimer's disease (AD) and are implicated in synapse loss, one of the best predictors of memory decline that characteriz
Externí odkaz:
https://doaj.org/article/de6c79add7ca4f33aa2485f2bddab86d
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 12, p 3748 (2018)
Myocardial infarction (MI) in animal models induces cognitive deficits as well as the activation of caspase in the limbic system; both can be blocked by 2 weeks of treatment following MI using tricyclic antidepressants or selective serotonin uptake b
Externí odkaz:
https://doaj.org/article/15ceb50437784eb7b268c0ae58295c27
Autor:
Xin-Kang Tong, Nektaria Nicolakakis, Priscilla Fernandes, Brice Ongali, Jonathan Brouillette, Rémi Quirion, Edith Hamel
Publikováno v:
Neurobiology of Disease, Vol 35, Iss 3, Pp 406-414 (2009)
Cerebrovascular dysfunctions appear to contribute to Alzheimer's disease (AD) pathogenesis and the associated cognitive decline. Recently, it has been suggested that statins could be beneficial to AD patients independently from their cholesterol-lowe
Externí odkaz:
https://doaj.org/article/22e6ee1f831d49a6ad7c5df8a85f9484
Autor:
Jian Xu, Manavi Chatterjee, Tyler D Baguley, Jonathan Brouillette, Pradeep Kurup, Debolina Ghosh, Jean Kanyo, Yang Zhang, Kathleen Seyb, Chimezie Ononenyi, Ethan Foscue, George M Anderson, Jodi Gresack, Gregory D Cuny, Marcie A Glicksman, Paul Greengard, TuKiet T Lam, Lutz Tautz, Angus C Nairn, Jonathan A Ellman, Paul J Lombroso
Publikováno v:
PLoS Biology, Vol 12, Iss 8, p e1001923 (2014)
STEP (STriatal-Enriched protein tyrosine Phosphatase) is a neuron-specific phosphatase that regulates N-methyl-D-aspartate receptor (NMDAR) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) trafficking, as well as ERK1/2, p38
Externí odkaz:
https://doaj.org/article/464c724e9a9e498caf07c3427d02b23b
Autor:
Frédéric Calon, Jonathan Brouillette, Christopher M. Norris, Julien Dufort-Gervais, Laurence Charbonneau, Valérie Mongrain, Chloé Provost
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports
Scientific Reports
Synapse loss occurs early and correlates with cognitive decline in Alzheimer’s disease (AD). Synaptotoxicity is driven, at least in part, by amyloid-beta oligomers (Aβo), but the exact synaptic components targeted by Aβo remain to be identified.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9927dcceee202b6cbe17fd9bc788bfa2
http://link.springer.com/article/10.1038/s41598-020-63255-6
http://link.springer.com/article/10.1038/s41598-020-63255-6
Autor:
Audrey Hector, Christina McAnulty, Maude-Eloise Piche-Lemieux, Jonathan Brouillette, Claire Alves-Pires, Valérie Buée-Scherrer, Luc Buée
Publikováno v:
FASEB Journal
FASEB Journal, 2020, 34 (2), pp.2968-2977. ⟨10.1096/fj.201902135R⟩
FASEB Journal, Federation of American Society of Experimental Biology, 2020, 34 (2), pp.2968-2977. ⟨10.1096/fj.201902135R⟩
FASEB Journal, 2020, 34 (2), pp.2968-2977. ⟨10.1096/fj.201902135R⟩
FASEB Journal, Federation of American Society of Experimental Biology, 2020, 34 (2), pp.2968-2977. ⟨10.1096/fj.201902135R⟩
International audience; Tau hyperphosphorylation is a major neuropathological hallmark of many neurodegenerative disorders such as Alzheimer's disease. Several anesthetics have been shown previously to induced marked tau hyperphosphorylation. Althoug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0d800270f963b65092e9d5edbd76b13
https://doi.org/10.1096/fj.201902135r
https://doi.org/10.1096/fj.201902135r
Publikováno v:
Neurobiology of Learning and Memory. 160:108-117
Alzheimer's disease (AD) is a debilitating neurodegenerative disease characterized by progressive hippocampal-dependent explicit memory deficits that begin at the onset of the illness. An early hallmark of AD is the accumulation of amyloid-beta (Aß)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddcf0a00d55628e627b79cba3d2a1837
https://doi.org/10.1016/j.nlm.2018.06.009
https://doi.org/10.1016/j.nlm.2018.06.009