Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Jonathan Bond"'
Autor:
Thomas Lefeivre, Cosmin Tudose, Theodora Grosu, Luke Jones, Theresa Leon, Kieran Wynne, Giorgio Oliviero, Owen Smith, Amélie Trinquand, Marc Mansour, Colm Ryan, Jonathan Bond
Publikováno v:
HemaSphere, Vol 7, p e9936489 (2023)
Externí odkaz:
https://doaj.org/article/565d4946c5ee4cdf9d1da982a0fe24d0
Autor:
Thomas Steimlé, Marie-Emilie Dourthe, Marion Alcantara, Aurore Touzart, Mathieu Simonin, Johanna Mondesir, Ludovic Lhermitte, Jonathan Bond, Carlos Graux, Nathalie Grardel, Jean-Michel Cayuela, Isabelle Arnoux, Virginie Gandemer, Marie Balsat, Norbert Vey, Elizabeth Macintyre, Norbert Ifrah, Hervé Dombret, Arnaud Petit, André Baruchel, Philippe Ruminy, Nicolas Boissel, Vahid Asnafi
Publikováno v:
Blood Cancer Journal, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract T-cell acute lymphoblastic leukemias (T-ALL) represent 15% of pediatric and 25% of adult ALL. Since they have a particularly poor outcome in relapsed/refractory cases, identifying prognosis factors at diagnosis is crucial to adapting treatme
Externí odkaz:
https://doaj.org/article/c899cfc57fba4ffba0873e05dddf4ebb
Autor:
Teerna Bhattacharyya, Jonathan Bond
Publikováno v:
Cancers, Vol 15, Iss 6, p 1693 (2023)
Epigenetic dysregulation is a hallmark of many haematological malignancies and is very frequent in acute myeloid leukaemia (AML). A cardinal example is the altered activity of the Polycomb Repressive Complex 2 (PRC2) due to somatic mutations and dele
Externí odkaz:
https://doaj.org/article/872a72b4c58e41949520c873ea51a1b0
Autor:
Gaëlle Cordonnier, Amit Mandoli, Nicolas Cagnard, Guillaume Hypolite, Ludovic Lhermitte, Els Verhoeyen, Vahid Asnafi, Niall Dillon, Elizabeth Macintyre, Joost H.A. Martens, Jonathan Bond
Publikováno v:
Cell Reports, Vol 30, Iss 2, Pp 299-307.e3 (2020)
Summary: Mutations and deletions of polycomb repressive complex (PRC) components are increasingly recognized to affect tumor biology in a range of cancers. However, little is known about how genetic alterations of PRC-interacting molecules such as th
Externí odkaz:
https://doaj.org/article/b70382223de44ef4b547936a29ddd50a
Autor:
Jonathan Bond, Aurore Touzart, Stéphane Leprêtre, Carlos Graux, Mario Bargetzi, Ludovic Lhermitte, Guillaume Hypolite, Thibaut Leguay, Yosr Hicheri, Gaëlle Guillerm, Karin Bilger, Véronique Lhéritier, Mathilde Hunault, Françoise Huguet, Yves Chalandon, Norbert Ifrah, Elizabeth Macintyre, Hervé Dombret, Vahid Asnafi, Nicolas Boissel
Publikováno v:
Haematologica, Vol 104, Iss 8 (2019)
The prognostic implications of DNMT3A genotype in T-cell acute lymphoblastic leukemia are incompletely understood. We performed comprehensive genetic and clinico-biological analyses of T-cell acute lymphoblastic leukemia patients with DNMT3A mutation
Externí odkaz:
https://doaj.org/article/c7874af4303e437f94ab5be0fb3f19e0
Autor:
Jonathan Bond, Tony Marchand, Aurore Touzart, Agata Cieslak, Amélie Trinquand, Laurent Sutton, Isabelle Radford-Weiss, Ludovic Lhermitte, Salvatore Spicuglia, Hervé Dombret, Elizabeth Macintyre, Norbert Ifrah, Jean-François Hamel, Vahid Asnafi
Publikováno v:
Haematologica, Vol 101, Iss 6 (2016)
Gene expression studies have consistently identified a HOXA-overexpressing cluster of T-cell acute lymphoblastic leukemias, but it is unclear whether these constitute a homogeneous clinical entity, and the biological consequences of HOXA overexpressi
Externí odkaz:
https://doaj.org/article/ed2afdea5a174c32ac382a1e2e2a1fbb
Autor:
Vahid Asnafi, Salvatore Spicuglia, Nicolas Boissel, Elizabeth Macintyre, Jacques Ghysdael, Gaëlle Cordonnier, Aurélie Bergon, Mohamed Belhocine, Guillaume Hypolite, Christine Tran Quang, Jonathan Bond
Supplementary Methods, Tables, figures and references.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3a76268f6a73b48b2563c9b9d1b8cf9
https://doi.org/10.1158/1541-7786.22513294
https://doi.org/10.1158/1541-7786.22513294
Autor:
Ana Rio-Machin, Findlay Bewicke-Copley, Jiexin Zheng, Pedro Casado Izquierdo, Juho J. Miettinen, Naeem Khan, Jonas Demeulemeester, Szilvia Krizsán, Christopher Middleton, Sam Benkwitz-Bedford, Joseph Saad, Amaia Vilas-Zornoza, Teresa Ezponda, William Grey, Vincent-Philippe Lavallée, Alexis Nolin-Lapalme, Farideh Miraki-Moud, Janet Matthews, Marianne Grantham, Ryan J Colm, Jonathan Bond, Doriana Di Bella, Krister Wennerberg, Alun Parsons, Andy G.X. Zeng, Hannah Armes, Karina Close, Fadimana Kaya, Kevin Rouault-Pierre, John G. Gribben, Felipe Prosper, James Cavenagh, John E. Dick, Sylvie D Freeman, Peter Van Loo, Csaba Bödör, Guy Sauvageau, Kimmo Porkka, Caroline A. Heckman, Jun Wang, Jean-Baptiste Cazier, David Taussig, Dominique Bonnet, Pedro Cutillas, Jude Fitzgibbon
Publikováno v:
Blood. 140:1030-1032
Gene regulatory networks (GRNs) are often deregulated in tumor cells, resulting in altered transcriptional programs that facilitate tumor growth. These altered networks may make tumor cells vulnerable to the inhibition of specific regulatory proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f81a1c5810ce7f86cedb8fb112aaf62f
https://doi.org/10.1101/2023.03.02.530664
https://doi.org/10.1101/2023.03.02.530664
Autor:
Elisa Laurenti, Jonathan Bond, Antoine Pinton, Elizabeth Macintyre, Luke Jones, Amélie Trinquand, Thomas Lefeivre
Publikováno v:
The FEBS Journal. 289:4355-4370
It is essential to relate the biology of acute leukaemia to normal blood cell development. In this review, we discuss how modern models of haematopoiesis might inform approaches to diagnosis and management of immature leukaemias, with a specific focu