Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Jonathan Beagan"'
Publikováno v:
Neurobiology of Disease, Vol 110, Iss , Pp 218-230 (2018)
The selective vulnerability of motor neurons in amyotrophic lateral sclerosis (ALS) is evident by sparing of a few subpopulations during this fast progressing and debilitating degenerative disease. By studying the gene expression profile of resilient
Externí odkaz:
https://doaj.org/article/1374a721bb864b19979bea97b3ba1bea
Autor:
Emily M. Rocha, Gaynor A. Smith, Eric Park, Hongmei Cao, Eilish Brown, Melissa A. Hayes, Jonathan Beagan, Jesse R. McLean, Sarah C. Izen, Eduardo Perez-Torres, Penelope J. Hallett, Ole Isacson
Publikováno v:
Neurobiology of Disease, Vol 82, Iss , Pp 495-503 (2015)
Diminished lysosomal function can lead to abnormal cellular accumulation of specific proteins, including α-synuclein, contributing to disease pathogenesis of vulnerable neurons in Parkinson's disease (PD) and related α-synucleinopathies. GBA1 encod
Externí odkaz:
https://doaj.org/article/2ef89fe7a22c4b478cadce9df032959e
Autor:
Gaynor A Smith, Emily M Rocha, Thomas Rooney, Pascal Barneoud, Jesse R McLean, Jonathan Beagan, Teresia Osborn, Madeleine Coimbra, Yongyi Luo, Penelope J Hallett, Ole Isacson
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121072 (2015)
Dopaminergic neurons in the substantia nigra pars compacta (SNpc) are characterized by the expression of genes required for dopamine synthesis, handling and reuptake and the expression of these genes is largely controlled by nuclear receptor related
Externí odkaz:
https://doaj.org/article/dfab7d0f8b5b46beacc06e48764ebbc2