Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Jonathan B. Ward"'
Publikováno v:
Environmental Health Insights, Vol 11 (2017)
Since its beginning, more than 117 years ago, the compression-ignition engine, or diesel engine, has grown to become a critically important part of industry and transportation. Public concerns over the health effects from diesel emissions have driven
Externí odkaz:
https://doaj.org/article/4731fbac3f5940d8a5c97ef34cf5c05d
Autor:
Jeffrey K. Wickliffe, Jonathan B. Ward, Errol C. Friedberg, Lori A. Galbert, Lance M. Hallberg, Marinel M. Ammenheuser, Sherif Z. Abdel-Rahman, Jingwu Xie, Stacy M. Herring, R. Stephen Lloyd, Oscar E. Masters
Publikováno v:
Chemico-Biological Interactions. 166:226-231
1,3-Butadiene (BD) is a well-documented mutagen and carcinogen in rodents and is currently classified as a probable carcinogen in humans. Studies investigating workers exposed to BD indicate that, in some plants, there may be an increased genetic ris
Autor:
Lance M, Hallberg, Jonathan B, Ward, Caterina, Hernandez, Bill T, Ameredes, Jeffrey K, Wickliffe
Publikováno v:
Research report (Health Effects Institute). (184)
In 2001, the U.S. Environmental Protection Agency (EPA*) and the California Air Resources Board (CARB) adopted new standards for diesel fuel and emissions from heavy-duty diesel engines. By 2007, diesel engines were required to meet these new standar
Autor:
Judah I. Rosenblatt, Jeffrey K. Wickliffe, Jonathan B. Ward, Curtis J. Omiecinski, Marinel M. Ammenheuser, Sherif Z. Abdel-Rahman
Publikováno v:
Toxicological Sciences. 85:624-631
The carcinogenic effects of 1,3-butadiene (BD), a mutagenic chemical widely used in the manufacture of synthetic rubber, are likely initiated through its epoxide metabolites. In humans, these epoxides are detoxified predominantly by hydrolysis, a rea
Autor:
Sherif Z. Abdel-Rahman, Randa El-Zein, Zhen Yang, Jonathan B. Ward, Maria T. Morandi, Marinel M. Ammenheuser, Thomas H. Stock
Publikováno v:
Environmental and Molecular Mutagenesis. 41:140-146
The carcinogenic effects of 1,3-butadiene (BD), a chemical widely used in the rubber industry, are thought to be due to its epoxide metabolites. In humans, these epoxides are detoxified predominantly by hydrolysis, a reaction mediated by the microsom
Publikováno v:
Environmental Health Insights, Vol 11 (2017)
Environmental Health Insights
Environmental Health Insights
Since its beginning, more than 117 years ago, the compression-ignition engine, or diesel engine, has grown to become a critically important part of industry and transportation. Public concerns over the health effects from diesel emissions have driven
Autor:
Darlene A. Hastings-Smith, Jonathan B. Ward, Judah I. Rosenblatt, Sherif Z. Abdel-Rahman, Marinel M. Ammenheuser, William E. Bechtold
Publikováno v:
Environmental Health Perspectives
1,3-Butadiene (BD), which is used to make styrene-butadiene rubber, is a potent carcinogen in mice and a probable carcinogen, associated with leukemia, in humans. We have previously used HPRT mutation as a biomarker to evaluate exposures to BD in a m
Autor:
Davis H. Daiker, Jonathan B. Ward, Shipp Bk, Schoenfeld Ha, Mary Treinen Moslen, Gisela Witz, Klimpel Gr
Publikováno v:
Journal of Toxicology and Environmental Health, Part A. 59:181-196
Potential additive effects of ethanol consumption, a common life-style factor, and low-level benzene exposure, a ubiquitous environmental pollutant, were investigated. Ethanol is a potent inducer of the cytochrome P-450 2E1 (CYP2E1) enzyme, which bio
Publikováno v:
Environmental and Molecular Mutagenesis. 36:59-71
1,3-Butadiene (BD) has been shown to be a potent animal carcinogen and a probable human carcinogen, yet the molecular mechanisms of BD genotoxicity and carcinogenicity still are not fully understood. Our hypothesis is that metabolites of BD induce sp
Publikováno v:
Environmental and Molecular Mutagenesis. 35:1-8
Determination of the frequency of mutations at hprt or other loci in human lymphocytes provides a useful biomarker for human exposure to mutagens. One problem, however, is distinguishing between unique mutants and sibling mutants arising as progeny o